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  1. Progesterone Receptor Membrane Component 1 (PGRMC1) is expressed in many cancer cells, where it is associated with detrimental patient outcomes. It contains phosphorylated tyrosines which evolutionarily preced...

    Authors: Bashar M. Thejer, Partho P. Adhikary, Amandeep Kaur, Sarah L. Teakel, Ashleigh Van Oosterum, Ishith Seth, Marina Pajic, Katherine M. Hannan, Megan Pavy, Perlita Poh, Jalal A. Jazayeri, Thiri Zaw, Dana Pascovici, Marina Ludescher, Michael Pawlak, Juan C. Cassano…
    Citation: BMC Molecular and Cell Biology 2020 21:24
  2. Intervertebral disc degeneration (IDD) is characterized by the loss of nucleus pulposus cells (NPCs) and phenotypic abnormalities. Accumulating evidence suggests that long noncoding RNAs (lncRNAs) are involved...

    Authors: Hongyu Zheng, Tingting Wang, Xiangmin Li, Wei He, Zhiqiang Gong, Zhenkai Lou, Bing Wang and Xingguo Li
    Citation: BMC Molecular and Cell Biology 2020 21:23
  3. Collagen is a structural protein that provides mechanical stability and defined architectures to skin. In collagen-based skin disorders this stability is lost, either due to mutations in collagens or in the ch...

    Authors: Essak S. Khan, Shrikrishnan Sankaran, Lorena Llontop and Aránzazu del Campo
    Citation: BMC Molecular and Cell Biology 2020 21:22
  4. Ubiquitination and ubiquitin-like protein post-translational modifications play an enormous number of roles in cellular processes. These modifications are constituted of multistep reaction cascades. Readily im...

    Authors: Gabriel Fenteany, Paras Gaur, Gaurav Sharma, Lajos Pintér, Ernő Kiss and Lajos Haracska
    Citation: BMC Molecular and Cell Biology 2020 21:21
  5. Acute myocardial infarction (AMI) is the leading cause of death globally and has thus placed a heavy burden on healthcare. Tanshinone IIA (TSA) is a major active compound, extracted from Salvia miltiorrhiza Bu...

    Authors: Liye Chen, Lili Wei, Qiongyang Yu, Haozhe Shi and George Liu
    Citation: BMC Molecular and Cell Biology 2020 21:20
  6. Transcriptional responses required to maintain cellular homeostasis or to adapt to environmental stress, is in part mediated by several nucleic-acid associated proteins. In this study, we sought to establish a...

    Authors: Nastassja L. Kriel, Tiaan Heunis, Samantha L. Sampson, Nico C. Gey van Pittius, Monique J. Williams and Robin M. Warren
    Citation: BMC Molecular and Cell Biology 2020 21:19
  7. Congenital dyserythropoietic anemia type I (CDA I), is an autosomal recessive disease with macrocytic anemia in which erythroid precursors in the bone marrow exhibit pathognomonic abnormalities including spong...

    Authors: Grace Swickley, Yehoshua Bloch, Lidor Malka, Adi Meiri, Sharon Noy-Lotan, Amiel Yanai, Hannah Tamary and Benny Motro
    Citation: BMC Molecular and Cell Biology 2020 21:18
  8. dADD1 and dXNP proteins are the orthologs in Drosophila melanogaster of the ADD and SNF2 domains, respectively, of the ATRX vertebrate’s chromatin remodeler, they suppress position effect variegation phenotypes a...

    Authors: Silvia Meyer-Nava, Amada Torres, Mario Zurita and Viviana Valadez-Graham
    Citation: BMC Molecular and Cell Biology 2020 21:17
  9. Following publication of the original article [1], an error was reported in the tagging of Eugene H. Johnson and Remya R. Nair in the author group.

    Authors: Yasmin ElTahir, Amna Al-Araimi, Remya R. Nair, Kaija J. Autio, Hongmin Tu, Jack C. Leo, Waleed Al-Marzooqi and Eugene H. Johnson
    Citation: BMC Molecular and Cell Biology 2020 21:16

    The original article was published in BMC Molecular and Cell Biology 2019 20:55

  10. Tartrate–resistant acid phosphatase (TRAP/ ACP5) belongs to the binuclear metallophosphatase family and is present in two isoforms. The primary translation product is an uncleaved TRAP 5a isoform with low phos...

    Authors: Anja Reithmeier, Maria Norgård, Barbro Ek-Rylander, Tuomas Näreoja and Göran Andersson
    Citation: BMC Molecular and Cell Biology 2020 21:15
  11. Fibronectin (FN) assembly into an insoluble fibrillar matrix is a crucial step in many cell responses to extracellular matrix (ECM) properties, especially with regards to the integrin-related mechanosensitive ...

    Authors: David Gagné, Yannick D. Benoit, Jean-François Groulx, Pierre H. Vachon and Jean-François Beaulieu
    Citation: BMC Molecular and Cell Biology 2020 21:14
  12. Alzheimer’s disease is the most common neurodegenerative disease in the elderly. Amyloid-β protein (Aβ) is the major component of neuritic plaques which are the hallmark of AD pathology. β-site APP cleaving en...

    Authors: Kaixin Qiu, Wenping Liang, Shuai Wang, Tingting Kong, Xin Wang, Chunyan Li, Zhe Wang and Yili Wu
    Citation: BMC Molecular and Cell Biology 2020 21:13
  13. Gap junction protein alpha 3 (GJA3), an important pathogenic gene of congenital cataracts, encodes the transmembrane protein connexin46, which functions as an intercellular channel for voltage and chemical gating...

    Authors: Mingzhou Zhang, Chen Huang, Zhenyu Wang, Huibin Lv and Xuemin Li
    Citation: BMC Molecular and Cell Biology 2020 21:12
  14. Following publication of the original article [1], the authors reported an error that occurred during the production process.

    Authors: Xiaoyan Guo, Dianke Chen, Qingxian Cai, Zhanlian Huang, Wenxiong Xu, Liang Peng and Ping Chen
    Citation: BMC Molecular and Cell Biology 2020 21:10

    The original article was published in BMC Molecular and Cell Biology 2020 21:6

  15. Gene transfer by electroporation is an established method for the non-viral mediated transfection of mammalian cells. Primary cells pose a particular challenge for electroporation-mediated gene transfer, since...

    Authors: Iqbal Hyder, Shahin Eghbalsaied and Wilfried A. Kues
    Citation: BMC Molecular and Cell Biology 2020 21:9
  16. TgDCX is a doublecortin-domain protein associated with the conoid fibers, a set of strongly curved non-tubular tubulin-polymers in Toxoplasma. TgDCX deletion impairs conoid structure and parasite invasion. TgDCX ...

    Authors: Jacqueline M. Leung, Eiji Nagayasu, Yu-Chen Hwang, Jun Liu, Phillip G. Pierce, Isabelle Q. Phan, Robin A. Prentice, John M. Murray and Ke Hu
    Citation: BMC Molecular and Cell Biology 2020 21:8
  17. Interferon-alpha (IFNα) is a first-line treatment option for chronic hepatitis B virus (HBV) infection, but the severe systemic side-effects limited its clinical application. Interferon-lambda (IFNλ) with comp...

    Authors: Xiaoyan Guo, Dianke Chen, Qingxian Cai, Zhanlian Huang, Wenxiong Xu, Liang Peng and Ping Chen
    Citation: BMC Molecular and Cell Biology 2020 21:6

    The Correction to this article has been published in BMC Molecular and Cell Biology 2020 21:10

  18. The tumor suppressor p53 is a major regulator of the DNA damage response and has been suggested to selectively bind and activate cell-type specific gene expression programs. However recent studies and meta-ana...

    Authors: Antonina Hafner, Lyubov Kublo, Michael Tsabar, Galit Lahav and Jacob Stewart-Ornstein
    Citation: BMC Molecular and Cell Biology 2020 21:5
  19. PM2.5 is associated closely with an increased risk of membranous nephropathy (MN), however, whether PM2.5 could induce podocytes injury, the underlying pathology for MN, has not be thoroughly studied. Triptoli...

    Authors: Qiang Wan, Zhongyong Liu, Ming Yang, Peng Deng, Nana Tang and Yanwei Liu
    Citation: BMC Molecular and Cell Biology 2020 21:4
  20. ZNF143 is an important transcriptional regulator protein conserved in metazoans and estimated to bind over 2000 promoter regions of both messenger RNA and small nuclear RNA genes. The use of zebrafish is a use...

    Authors: Laura Huning and Gary R. Kunkel
    Citation: BMC Molecular and Cell Biology 2020 21:3
  21. Monoclonal antibodies (mAbs) and their derivatives have become one of the most important classes of therapeutic drugs. Their multiple applications increased the interest for understanding their complex structu...

    Authors: Mercè Farràs, Ramón Román, Marc Camps, Joan Miret, Óscar Martínez, Xavier Pujol, Antoni Casablancas and Jordi Joan Cairó
    Citation: BMC Molecular and Cell Biology 2020 21:2
  22. In the bovine placenta, intimate fetomaternal contacts are restricted to discrete placentomes. Here, widely branched fetal chorionic villi interdigitate with corresponding maternal caruncular crypts. The fetal...

    Authors: Marina Polei, Juliane Günther, Dirk Koczan and Rainer Fürbass
    Citation: BMC Molecular and Cell Biology 2020 21:1
  23. The biological process known as post-translational modification (PTM) is a condition whereby proteomes are modified that affects normal cell biology, and hence the pathogenesis. A number of PTMs have been disc...

    Authors: Abel Chandra, Alok Sharma, Abdollah Dehzangi, Daichi Shigemizu and Tatsuhiko Tsunoda
    Citation: BMC Molecular and Cell Biology 2019 20(Suppl 2):57

    This article is part of a Supplement: Volume 20 Supplement 2

  24. Toll-like receptor 9 is a key innate immune receptor involved in detecting infectious diseases and cancer. TLR9 activates the innate immune system following the recognition of single-stranded DNA oligonucleoti...

    Authors: Varun Khanna, Lei Li, Johnson Fung, Shoba Ranganathan and Nikolai Petrovsky
    Citation: BMC Molecular and Cell Biology 2019 20(Suppl 2):56

    This article is part of a Supplement: Volume 20 Supplement 2

  25. ZNF746 and ZNF777 belong to a subset of the large Krüppel-associated box (KRAB) zinc finger (ZNF) transcription factor family. They contain, like four other members in human, an additional conserved domain, th...

    Authors: Mohannad Al Chiblak, Felix Steinbeck, Hans-Jürgen Thiesen and Peter Lorenz
    Citation: BMC Molecular and Cell Biology 2019 20:60
  26. Multicellular entities like mammalian tissues or microbial biofilms typically exhibit complex spatial arrangements that are adapted to their specific functions or environments. These structures result from int...

    Authors: Jukka Intosalmi, Adrian C. Scott, Michelle Hays, Nicholas Flann, Olli Yli-Harja, Harri Lähdesmäki, Aimée M. Dudley and Alexander Skupin
    Citation: BMC Molecular and Cell Biology 2019 20:59
  27. In many important life activities, the execution of protein function depends on the interaction between proteins and ligands. As an important protein binding ligand, the identification of the binding site of t...

    Authors: Shan Wang, Xiuzhen Hu, Zhenxing Feng, Xiaojin Zhang, Liu Liu, Kai Sun and Shuang Xu
    Citation: BMC Molecular and Cell Biology 2019 20(Suppl 3):53

    This article is part of a Supplement: Volume 20 Supplement 3

  28. Proteins perform their functions by interacting with acid radical ions. Recently, it was a challenging work to precisely predict the binding residues of acid radical ion ligands in the research field of molecu...

    Authors: Liu Liu, Xiuzhen Hu, Zhenxing Feng, Xiaojin Zhang, Shan Wang, Shuang Xu and Kai Sun
    Citation: BMC Molecular and Cell Biology 2019 20(Suppl 3):52

    This article is part of a Supplement: Volume 20 Supplement 3

  29. Astral microtubules emanating from the mitotic centrosomes play pivotal roles in defining cell division axis and tissue morphogenesis. Previous studies have demonstrated that human transforming acidic coiled-c...

    Authors: Resmi Rajeev, Puja Singh, Ananya Asmita, Ushma Anand and Tapas K. Manna
    Citation: BMC Molecular and Cell Biology 2019 20:58
  30. Brucella is a facultative intracellular pathogen responsible for zoonotic disease brucellosis. Little is known about the molecular basis of Brucella adherence to host cells. In the present study, the possible rol...

    Authors: Yasmin ElTahir, Amna Al-Araimi, Remya R. Nair, Kaija J. Autio, Hongmin Tu, Jack C. Leo, Waleed Al-Marzooqi and Eugene H. Johnson
    Citation: BMC Molecular and Cell Biology 2019 20:55

    The Correction to this article has been published in BMC Molecular and Cell Biology 2020 21:16

  31. Reactive oxygen species (ROS) produce different lesions in DNA by ROS-induced DNA damage. Detection and quantification of 8-oxo-7,8-dihydroguanine (8-oxoG) within cells are important for study. Human ribosomal...

    Authors: Dong Min Kang, Jong-Il Shin, Ji Beom Kim, Kyungho Lee, Ji Hyung Chung, Hye-Won Yang, Kil-Nam Kim and Ye Sun Han
    Citation: BMC Molecular and Cell Biology 2019 20:54
  32. Mesenchymal stromal cells in the endosteal niche lining compact bone (CB-MSCs) represent a heterogeneous population, all of which contribute to bone repair and remodelling. Hyperglycaemia associated with type ...

    Authors: Ahmed Makki A. Al-Qarakhli, Norhayati Yusop, Rachel J. Waddington and Ryan Moseley
    Citation: BMC Molecular and Cell Biology 2019 20:51
  33. Olfactomedin-1 (Olfm1; also known as Noelin or Pancortin) is a highly-expressed secreted brain and retina protein and its four isoforms have different roles in nervous system development and function. Structur...

    Authors: Matti F. Pronker, Hugo van den Hoek and Bert J. C. Janssen
    Citation: BMC Molecular and Cell Biology 2019 20:50
  34. Several reports indicated that the expression of Yes-associated protein (YAP) was associated with multi-drug resistance. Acidic microenvironment increased by the overexpression of vacuolar-ATPase (V-ATPase) wa...

    Authors: Jing He, Xiao-Yan Shi, Zhi-min Li, Xiao-hua Pan, Ze-Lian Li, Ying Chen, Shi-Jie Yan and Lan Xiao
    Citation: BMC Molecular and Cell Biology 2019 20:49
  35. Matrix mineralization is a key stage in bone formation involving in many bone-specific genes and signaling pathways. Emerging evidence indicate that long non-coding RNA (lncRNA) and microRNAs (miRNAs) play cru...

    Authors: Yuan Wu, Yu Jiang, Qiang Liu and Cui-Zhong Liu
    Citation: BMC Molecular and Cell Biology 2019 20:48
  36. In healthy subjects fibrinogen γ/γ‘ circulates at 8–15% of the total plasma fibrinogen concentration. Elevated levels of this variant have been associated with arterial thrombosis, and its diminution with veno...

    Authors: Miriam Cantero, Héctor Rojas, Eduardo Anglés-Cano and Rita Marchi
    Citation: BMC Molecular and Cell Biology 2019 20:47
  37. It was reported that microRNA-21(miR-21) was differentially expressed in the keratinocytes of psoriasis patients, and it may influence the apoptosis and proliferation of cells. The role of lncRNA maternally ex...

    Authors: Hai-Yan Jia, Kai Zhang, Wen-Jing Lu, Gui-Wen Xu, Jian-Fen Zhang and Zhan-Li Tang
    Citation: BMC Molecular and Cell Biology 2019 20:46
  38. The HongXin radish (Raphanus sativus L.), which contains the natural red pigment (red radish pigment), is grown in the Fuling district of Chongqing City. However, the molecular mechanisms underlying anthocyanin s...

    Authors: Jian Gao, Wen-Bo Li, Hong-Fang Liu and Fa-Bo Chen
    Citation: BMC Molecular and Cell Biology 2019 20:45
  39. Meiosis-I is a unique type of chromosome segregation where each chromosome aligns and segregates from its homolog. The mechanism of meiosis I homolog separation in different eukaryotes depends on their centrom...

    Authors: Akhilendra Pratap Bharati and Santanu Kumar Ghosh
    Citation: BMC Molecular and Cell Biology 2019 20:44
  40. All cells rely on lipids for key functions. Lipid transfer proteins allow lipids to exit the hydrophobic environment of bilayers, and cross aqueous spaces. One lipid transfer domain fold present in almost all ...

    Authors: Timothy P. Levine
    Citation: BMC Molecular and Cell Biology 2019 20:43
  41. Docking large ligands, and especially peptides, to protein receptors is still considered a challenge in computational structural biology. Besides the issue of accurately scoring the binding modes of a protein-...

    Authors: Didier Devaurs, Dinler A Antunes, Sarah Hall-Swan, Nicole Mitchell, Mark Moll, Gregory Lizée and Lydia E Kavraki
    Citation: BMC Molecular and Cell Biology 2019 20:42
  42. Microtubule proteins are able to produce electromagnetic fields and have an important role in memory formation, and learning. Therefore, microtubules have the potential to be affected by exogenous electromagne...

    Authors: Dariush Gholami, Gholamhossein Riazi, Rouhollah Fathi, Mohsen Sharafi and Abdolhossein Shahverdi
    Citation: BMC Molecular and Cell Biology 2019 20:41
  43. The essentially unlimited expansion potential and the pluripotency of human embryonic stem cells (hESCs) make them attractive for cell-based therapeutic purposes. Although hESCs can indefinitely proliferate in...

    Authors: Guillermo A. Videla-Richardson, Verónica A. Furmento, Carolina P. Garcia, Olivia Morris-Hanon, Gustavo E. Sevlever, Leonardo Romorini and María E. Scassa
    Citation: BMC Molecular and Cell Biology 2019 20:40
  44. A study has shown that miR-423-5p is highly expressed in proliferative diabetic retinopathy. However, the exact biological functions and mechanisms of miR-423-5p in diabetic retinopathy (DR) progression are cu...

    Authors: Qing Xiao, Yinu Zhao, Jia Xu, Wen-Jie Li, Yu Chen and Hong-Jing Sun
    Citation: BMC Molecular and Cell Biology 2019 20:39
  45. The EP4 prostanoid receptor is one of four GPCRs that mediate the diverse actions of prostaglandin E2 (PGE2). Novel selective EP4 receptor agonists would assist to further elucidate receptor sub-type function and...

    Authors: Melissa C. Holt, Chi S. Ho, M. Inés Morano, Stephen D. Barrett and Adam J. Stein
    Citation: BMC Molecular and Cell Biology 2019 20:37
  46. Whole-proteome distributions of protein isoelectric point (pI) values in different organisms are bi- or trimodal with some variations. It was suggested that the observed multimodality of the proteome-wide pI d...

    Authors: Atsushi Kurotani, Alexander A. Tokmakov, Ken-Ichi Sato, Vasily E. Stefanov, Yutaka Yamada and Tetsuya Sakurai
    Citation: BMC Molecular and Cell Biology 2019 20:36
  47. HPV16 infection is one of the main risk factors involved in the development of cervical cancer, mainly due to the high oncogenic potential of the viral proteins E6 and E7, which are involved in the different p...

    Authors: Hugo Alberto Rodríguez-Ruiz, Olga Lilia Garibay-Cerdenares, Berenice Illades-Aguiar, Sarita Montaño, Xiaowei Jiang and Marco Antonio Leyva-Vázquez
    Citation: BMC Molecular and Cell Biology 2019 20:35
  48. The PINK1:Parkin pathway regulates the autophagic removal of damaged and dysfunctional mitochondria. While the response of this pathway to complete loss of ΔΨm, as caused by high concentrations of mitochondria...

    Authors: J. Logan Bowling, Mary Catherine Skolfield, Wesley A. Riley, Andrew P. Nolin, Larissa C. Wolf and David E. Nelson
    Citation: BMC Molecular and Cell Biology 2019 20:33

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