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  1. Disruption of circadian rhythms is associated with neurological, endocrine and metabolic pathologies. We have recently shown that mice lacking functional type 3 deiodinase (DIO3), the enzyme that clears thyroi...

    Authors: Zhaofei Wu, M. Elena Martinez and Arturo Hernandez
    Citation: BMC Molecular and Cell Biology 2024 25:11
  2. OP9 mouse stromal cell line has been widely used to induce differentiation of human embryonic stem cells (hESCs) into hematopoietic stem/progenitor cells (HSPCs). However, the whole co-culture procedure usuall...

    Authors: Xin-xing Jiang, Meng-yi Song, Qi Li, Yun-jian Wei, Yuan-hua Huang and Yan-lin Ma
    Citation: BMC Molecular and Cell Biology 2024 25:10
  3. The alveolar epithelium is exposed to numerous stimuli, such as chemicals, viruses, and bacteria that cause a variety of pulmonary diseases through inhalation. Alveolar epithelial cells (AECs) cultured in vitr...

    Authors: Ikuya Tanabe, Kanae Ishimori and Shinkichi Ishikawa
    Citation: BMC Molecular and Cell Biology 2024 25:9
  4. Hypertension-induced mechanical stress on vascular smooth muscle cells (VSMCs) is a known risk factor for vascular remodeling, including vascular calcification. Caveolin-1 (Cav-1), an integral structural compo...

    Authors: Mohammad Shaver, Kassandra Gomez, Katherine Kaiser and Joshua D. Hutcheson
    Citation: BMC Molecular and Cell Biology 2024 25:8
  5. In recent years, the role of autophagy has been highlighted in the pathogenesis of diabetes and inflammatory lung diseases. In this study, using a diabetic model of mice, we investigated the expression of auto...

    Authors: Jafar Rezaie, Mojtaba Jahanghiri, Reza Mosaddeghi- Heris, Sina Hassannezhad, Nima Abdyazdani, Afshin Rahbarghazi and Mahdi Ahmadi
    Citation: BMC Molecular and Cell Biology 2024 25:7
  6. Macrophages promote angiogenesis, metastasis, and drug resistance in several cancers. Similarly, TonEBP/NFAT5 induces metastasis in renal carcinoma and colon cancer cells. However, the role of this transcripti...

    Authors: Hee Ju Song, Young Hwan Kim, Han Na Choi, Taehee Kim, Soo Jin Kim, Min Woong Kang and Sang Do Lee
    Citation: BMC Molecular and Cell Biology 2024 25:6
  7. Combination therapies in cancer treatment have demonstrated synergistic or additive outcomes while also reducing the development of drug resistance compared to monotherapy. This study explores the potential of...

    Authors: Tito N. Habib, Mohammed O. Altonsy, Salah A. Ghanem, Mohamed S. Salama and Mai A. Hosny
    Citation: BMC Molecular and Cell Biology 2024 25:5
  8. The lack of appropriate prognostic biomarkers remains a significant obstacle in the early detection of Head and Neck Squamous Cell Carcinoma (HNSCC), a cancer type with a high mortality rate. Despite considera...

    Authors: Md. Mizanur Rahman, Muhammad Mosaraf Hossain, Shafiqul Islam, Ridwan Ahmed, Mohit Majumder, Shantu Dey, Md. Kawser, Bishu Sarkar, Md. Ejajur Rahman Himu, Ali Asgar Chowdhury, Shakera Ahmed, Supran Biswas, Mostafa Mahfuzul Anwar, Mohammad Jamal Hussain, Rajib Kumar Shil, Sunanda Baidya…
    Citation: BMC Molecular and Cell Biology 2024 25:4
  9. Trypanosoma brucei is the causative agent for trypanosomiasis in humans and livestock, which presents a growing challenge due to drug resistance. While identifying novel drug targets is vital, the process is dela...

    Authors: Naghmeh Poorinmohammad and Reza Salavati
    Citation: BMC Molecular and Cell Biology 2024 25:3
  10. Fas-associated factor 1 (FAF1) is a multidomain protein that interacts with diverse partners to affect numerous cellular processes. Previously, we discovered two Small Ubiquitin-like Modifier (SUMO)-interactin...

    Authors: Chang-Han Chen, Hung-Wei Lin, Meng-Fang Huang, Chi-Wu Chiang, Kuen-Haur Lee, Nguyen Thanh Phuong, Zong-Yan Cai, Wen-Chang Chang and Ding-Yen Lin
    Citation: BMC Molecular and Cell Biology 2024 25:2
  11. Chronic alcohol exposure increases liver damage such as lipid accumulation and hepatitis, resulting in hepatic cirrhosis. Chronic alcohol intake is known to disturb circadian rhythms in humans and animals. DEC...

    Authors: Fuyuki Sato, Ujjal K. Bhawal, Kosuke Oikawa and Yasuteru Muragaki
    Citation: BMC Molecular and Cell Biology 2024 25:1
  12. Mitochondria are key cytoplasmic organelles in eukaryotic cells that generate adenosine triphosphate (ATP) through the electron transport chain and oxidative phosphorylation. Mitochondrial DNA (mtDNA) copy num...

    Authors: Mingyue Li, Keming Yang, Immaculata De Vivo, A. Heather Eliassen, Abrar A. Qureshi, Hongmei Nan and Jiali Han
    Citation: BMC Molecular and Cell Biology 2023 24:35
  13. Breast cancer is the most common malignant tumour in women. The early silk-splitting inhibitor protein 1 Emi1 is responsible for mediating ubiquitin protein degradation. The present study investigated the effe...

    Authors: Ying Kuang, Shengwen Huang, Shifan Tang, Zhaozhen Zhuo and Keyan Linghu
    Citation: BMC Molecular and Cell Biology 2023 24:34
  14. Cytopenia is the primary feature of Myelodysplastic Syndrome, even in the presence of hypercellular bone marrow. TNFα is recognized as both a proinflammatory, and proapoptotic cytokine with a well established ...

    Authors: Anggraini Iriani, Andhika Rachman, Rahayuningsih D. Setiabudy, Siti B. Kresno, Aru W. Sudoyo, Mansyur Arief, Alida R. Harahap and Marsya Kaila Fatina
    Citation: BMC Molecular and Cell Biology 2023 24:33
  15. The morphogenetic process of apical constriction, which relies on non-muscle myosin II (NMII) generated constriction of apical domains of epithelial cells, is key to the development of complex cellular pattern...

    Authors: Andy Zhao, Sophia Varady, Madelyn O’Kelley-Bangsberg, Vicki Deng, Amy Platenkamp, Petra Wijngaard, Miriam Bern, Wyatt Gormley, Elaine Kushkowski, Kat Thompson, Logan Tibbetts, A. Tamar Conner, David Noeckel, Aidan Teran, Anna Ritz and Derek A. Applewhite
    Citation: BMC Molecular and Cell Biology 2023 24:32
  16. Epithelial cells are an important part of the pathomechanism in chronic rhinosinusitis with nasal polyps. It is therefore essential to establish a robust method for the isolation and culture of epithelial cell...

    Authors: Jonghui Kim, Karla Hegener, Claudia Hagedorn, Daniel Weidinger, Kashin Jamal Jameel, Inga Marte Charlott Seuthe, Sabine Eichhorn, Florian Kreppel, Jonas Jae-Hyun Park and Jürgen Knobloch
    Citation: BMC Molecular and Cell Biology 2023 24:31
  17. Hydrogen-rich water (HRW) has been shown to prevent cognitive impairment caused by ionizing radiation. This study aimed to investigate the pharmacological effects and mechanisms of HRW on ionizing radiation by...

    Authors: Xiaoming Liu, Mengya Liu, Huan Liu, Hui Yuan, Yong Wang, Xiaoman Chen, Jianguo Li and Xiujun Qin
    Citation: BMC Molecular and Cell Biology 2023 24:30
  18. Inflammation plays a crucial role in the progression of Subacute Ruminal Acidosis (SARA). The experiment was designed to investigate anti-inflammatory effects of glycyrrhizin on goats ruminal epithelial cells ...

    Authors: Junfeng Liu, Bei Ma, Guang Hao, DuoDuo Su, Tianyang Wang, Ze Ding and Xuefeng Guo
    Citation: BMC Molecular and Cell Biology 2023 24:28
  19. Age-related hearing loss, known as presbycusis, is the result of auditory system degeneration. Numerous studies have suggested that reactive oxygen species (ROS) and mitochondrial oxidative damage play importa...

    Authors: Zhe Peng, Chunli Zhao, Zijing Yang, Shusheng Gong and Zhengde Du
    Citation: BMC Molecular and Cell Biology 2023 24:27
  20. Heterogeneous nuclear ribonucleoprotein K (HNRNPK) regulates pre-mRNA processing and long non-coding RNA localization in the nucleus. It was previously shown that shuttling of HNRNPK to the cytoplasm promotes ...

    Authors: Arwa Fallatah, Dimitrios G. Anastasakis, Amirhossein Manzourolajdad, Pooja Sharma, Xiantao Wang, Alexis Jacob, Sarah Alsharif, Ahmed Elgerbi, Pierre A. Coulombe, Markus Hafner and Byung Min Chung
    Citation: BMC Molecular and Cell Biology 2023 24:26
  21. Bone morphogenetic protein 9 (BMP9) has been shown to regulate processes such as angiogenesis, endothelial dysfunction, and tumorigenesis. However, the role of BMP9 in preeclampsia (PE) is unclear. The purpose...

    Authors: Xue Yang, Lingling Ren, Xiang Chen, Ying Pang, Baoxia Jia, Jing Sun and Xiaofang Quan
    Citation: BMC Molecular and Cell Biology 2023 24:24
  22. Emodin and aloe-emodin are two anthraquinones having positive effects in wound healing. However, their mechanism of action of wound healing is not fully understood. The MAP kinase family, which plays an active...

    Authors: Aysenur Gunaydin-Akyildiz, Rabia Sare Yanikoglu, Meltem Gulec, Gulbahar Ozge Alim-Toraman, Ebru Didem Kuran, Sezen Atasoy, Abdullah Olgun and Gulacti Topcu
    Citation: BMC Molecular and Cell Biology 2023 24:23
  23. Renal ischemia/reperfusion (I/R) injury is a major cause of acute kidney injury (AKI). Dysfunction of E74-like ETS transcription factor 4 (ELF4) leads to inflammation. This research intended to look into the f...

    Authors: Li Li, Shunying Wang and Wenming Wang
    Citation: BMC Molecular and Cell Biology 2023 24:22
  24. Janus kinase 3 (JAK3) is a member of the JAK family of tyrosine kinase proteins involved in cytokine receptor-mediated intracellular signal transduction through the JAK/STAT signaling pathway. JAK3 was previou...

    Authors: Amir Zareifard, Francis Beaudry and Kalidou Ndiaye
    Citation: BMC Molecular and Cell Biology 2023 24:21
  25. DYX1C1 (DNAAF4) and DCDC2 are two of the most replicated dyslexia candidate genes in genetic studies. They both have demonstrated roles in neuronal migration, in cilia growth and function and they both are cytosk...

    Authors: Andrea Bieder, Gayathri Chandrasekar, Arpit Wason, Steffen Erkelenz, Jay Gopalakrishnan, Juha Kere and Isabel Tapia-Páez
    Citation: BMC Molecular and Cell Biology 2023 24:20
  26. The platelet-derived growth factor (PDGF) family of ligands exerts their cellular effects by binding to α- and β-tyrosine kinase receptors (PDGFRα and PDGFRβ, respectively). SUMOylation is an important posttra...

    Authors: Kehuan Wang, Natalia Papadopoulos, Anahita Hamidi, Johan Lennartsson and Carl-Henrik Heldin
    Citation: BMC Molecular and Cell Biology 2023 24:19
  27. For the purpose of skeletal muscle engineering, primary myoblasts (Mb) and adipogenic mesenchymal stem cells (ADSC) can be co-cultured and myogenically differentiated. Electrospun composite nanofiber scaffolds...

    Authors: Aijia Cai, Paul Schneider, Zeng-Ming Zheng, Justus P. Beier, Marcus Himmler, Dirk W. Schubert, Volker Weisbach, Raymund E. Horch and Andreas Arkudas
    Citation: BMC Molecular and Cell Biology 2023 24:18
  28. Cytochrome P450 4F2 (CYP4F2) enzyme is a member of the CYP4 family responsible for the metabolism of fatty acids, therapeutic drugs, and signaling molecules such as arachidonic acid, tocopherols, and vitamin K...

    Authors: Mahvash Farajzadeh-Dehkordi, Ladan Mafakher, Fatemeh Samiee-Rad and Babak Rahmani
    Citation: BMC Molecular and Cell Biology 2023 24:17
  29. Hypoxic culture conditions have been used to study the impact of oxygen deprivation has on gene expression in a number of disease models. However, hypoxia response elements present in the promoter regions of s...

    Authors: Huan Ting Ong, Cecilia M. Prêle and Rodney J. Dilley
    Citation: BMC Molecular and Cell Biology 2023 24:16
  30. Nasopharyngeal carcinoma is a tumor with high malignancy and poor prognosis, which severely affects the health of the patients. LncRNAs and microRNAs are crucial for the occurrence and development of nasophary...

    Authors: Chunmao Jiang, Dandan Feng, Yu Zhang, Kun Yang, Xiaotong Hu and Qian Xie
    Citation: BMC Molecular and Cell Biology 2023 24:15
  31. Recent studies have reported that the circadian transcription factor aryl hydrocarbon receptor nuclear translocator like 2 (ARNTL2) promotes the metastatic progression of lung adenocarcinoma. However, the mole...

    Authors: Tao Wang, Kai Wang, Xu Zhu and Nan Chen
    Citation: BMC Molecular and Cell Biology 2023 24:14
  32. Human accelerated regions (HARs) are short conserved genomic sequences that have acquired significantly more nucleotide substitutions than expected in the human lineage after divergence from chimpanzees. The f...

    Authors: Hizran Khatoon, Rabail Zehra Raza, Shoaib Saleem, Fatima Batool, Saba Arshad, Muhammad Abrar, Shahid Ali, Irfan Hussain, Neil H. Shubin and Amir Ali Abbasi
    Citation: BMC Molecular and Cell Biology 2023 24:13
  33. Endometriosis cause decreases in life quality and pelvic pain in reproductive-age women. Methylation abnormalities played a functional role in the progression of endometriosis, this study aimed to explore the ...

    Authors: Mei Yang, Lin Li, Xiaojie Huang, Hui Xing, Li Hong and Chunfan Jiang
    Citation: BMC Molecular and Cell Biology 2023 24:12
  34. Hypoxia is considered a critical contributor to renal cell carcinoma progression, including invasion and metastasis. However, the potential mechanisms by which it promotes invasion and metastasis have not yet ...

    Authors: Jing Shi, Ruili Sha and Xilan Yang
    Citation: BMC Molecular and Cell Biology 2023 24:10
  35. This study was designed to investigate to test the effect of exosomes from urine-derived mesenchymal stem cells (USCs) on the survival and viability of aging retinal ganglion cells (RGCs), and explored the pre...

    Authors: Qi-Qin Dan, Li Chen, Lan-Lan shi, Xiu Zhou, Ting-Hua Wang and Hua Liu
    Citation: BMC Molecular and Cell Biology 2023 24:8
  36. Abnormal biogenesis and ribosome free function of ribosomal proteins (RPs) is important for tumorgenesis and development. Ribosomal protein L11 (RPL11) is a component of ribosomal 60 S large subunit with diffe...

    Authors: Jie Chen, Changda Lei, Huahua Zhang, Xiaoyong Huang, Yang Yang, Junli Liu, Yuna Jia, Haiyan Shi, Yunqing Zhang, Jing Zhang and Juan Du
    Citation: BMC Molecular and Cell Biology 2023 24:7
  37. Delta-9-tetrahydrocannabinol (THC) is the primary phytocannabinoid responsible for the psychoactive properties of cannabis and is known to interact with the endocannabinoid system, which is functionally presen...

    Authors: Vivien B. Truong, Ola S. Davis, Jade Gracey, Michael S. Neal, Jibran Y. Khokhar and Laura A. Favetta
    Citation: BMC Molecular and Cell Biology 2023 24:6
  38. Melanoma is the most lethal type of skin cancer that originates from the malignant transformation of melanocytes. Although novel treatments have improved patient survival in melanoma, the overall prognosis rem...

    Authors: Zahra Malakoutikhah, Zahra Mohajeri, Nasim Dana and Shaghayegh Haghjooy Javanmard
    Citation: BMC Molecular and Cell Biology 2023 24:5
  39. Bronchopulmonary dysplasia is a serious and lifelong pulmonary disease in premature neonates that influences around one-quarter of premature newborns. The wingless-related integration site /β-catenin signaling...

    Authors: Yuting Zhu, Yawen Li, Weilai Jin, Zhengying Li, Le Zhang, Yuanyuan Fang and Yanyu Zhang
    Citation: BMC Molecular and Cell Biology 2023 24:4
  40. Alterations in vascular smooth muscle cells (VSMCs) contribute to the pathogenesis of intracranial aneurysms (IAs). However, molecular mechanisms underlying these changes remain unknown. The present study aime...

    Authors: Jichong Xu and Chun Fang
    Citation: BMC Molecular and Cell Biology 2023 24:3
  41. Autophagy and pyroptosis of macrophages play important protective or detrimental roles in sepsis. However, the underlying mechanisms remain unclear. High mobility group box protein 1 (HMGB1) is associated with...

    Authors: Jiawei Shang, Feng Zhao, Yongmei Cao, Feng Ping, Wei Wang and Yingchuan Li
    Citation: BMC Molecular and Cell Biology 2023 24:2
  42. Tendon injury is associated with oxidative stress, leading to reactive oxygen species (ROS) production and inflammation. N-acetyl-L-cysteine (NAC) is a potent antioxidant. However, how NAC affects the biologic...

    Authors: Kang Lu, Mei Zhou, Liyuan Wang, Yang Wang, Hong Tang, Gang He, Huan Wang, Chuyue Tang, Jie He, Wei Wang, Kanglai Tang, Yunjiao Wang and Zhongliang Deng
    Citation: BMC Molecular and Cell Biology 2023 24:1
  43. Considering the high correlation between the functional decline in Alzheimer’s disease (AD) and the propagation of aggregated tau protein, many research efforts are focused on determining the underlying molecu...

    Authors: Andreia Ferreira, Ines Royaux, Jian Liu, Zhangjie Wang, Guowei Su, Diederik Moechars, Nico Callewaert and Louis De Muynck
    Citation: BMC Molecular and Cell Biology 2022 23:61
  44. Cold inducible RNA-binding protein (CIRP) is a key protein in the hypothermic therapy. Highly expressed CIRP exerts a neuroprotective effect on neurons. The aim of this study is to provide the evidence of the ...

    Authors: Aijun Liu, Shouchun Li, Yongcheng Jiao, Haibo Kong and Zhiwen Zhang
    Citation: BMC Molecular and Cell Biology 2022 23:58

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