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  1. Transgenic mice have proven to be a powerful system to study normal and pathological gene functions. Here we describe an attempt to generate a transgenic mouse model for choroideremia (CHM), a slow-onset X-lin...

    Authors: José S Ramalho, Ross Anders, Gesine B Jaissle, Mathias W Seeliger, Clare Huxley and Miguel C Seabra

    Citation: BMC Cell Biology 2002 3:26

    Content type: Research article

    Published on:

  2. Members of the Rab GTPase family regulate intracellular protein trafficking, but the specific function of Rab24 remains unknown. Several attributes distinguish this protein from other members of the Rab family...

    Authors: William A Maltese, Gwendolyn Soule, William Gunning, Edward Calomeni and Brandy Alexander

    Citation: BMC Cell Biology 2002 3:25

    Content type: Research article

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  3. Down syndrome is the most frequent genetic disorder in humans. Rare cases involving partial trisomy of chromosome 21 allowed a small chromosomal region common to all carriers, called Down Syndrome Critical Reg...

    Authors: Sandra Cristina Pfister, Gláucia Maria Machado-Santelli, Sang Won Han and Flávio Henrique-Silva

    Citation: BMC Cell Biology 2002 3:24

    Content type: Research article

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  4. Epstein-Barr virus (EBV) infects resting B-lymphocytes and transforms them into immortal proliferating lymphoblastoid cell lines (LCLs) in vitro. The transformed immunoblasts may grow up as immunoblastic lymphoma...

    Authors: Elena Kashuba, Vladimir Kashuba, Tatjana Sandalova, George Klein and Laszlo Szekely

    Citation: BMC Cell Biology 2002 3:23

    Content type: Research article

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  5. The P-glycoprotein (P-gp), an ATP binding cassette transmembrane transporter, is expressed by astrocytes in the adult brain, and is positively modulated during astrogliosis. In a search for factors involved in...

    Authors: Christelle Monville, Christiane Fages, Anne-Marie Feyens, Véronique d'Hondt, Catherine Guillet, Ann Vernallis, Hugues Gascan and Marc Peschanski

    Citation: BMC Cell Biology 2002 3:20

    Content type: Research article

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  6. Cortical myosin-II filaments in Dictyostelium discoideum display enrichment in the posterior of the cell during cell migration and in the cleavage furrow during cytokinesis. Filament assembly in turn is regulated...

    Authors: Wenchuan Liang, Lucila S Licate, Hans M Warrick, James A Spudich and Thomas T Egelhoff

    Citation: BMC Cell Biology 2002 3:19

    Content type: Research article

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  7. Alternative exons encode different isoforms of the human insulin-like growth factor-I (IGF-I) precursor without altering mature IGF-I. We hypothesized that the various IGF-I precursors may traffic IGF-I differ...

    Authors: Daniel SW Tan, Alexandra Cook and Shern L Chew

    Citation: BMC Cell Biology 2002 3:17

    Content type: Research article

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  8. The intracellular signaling events of the Bone Morphogenetic Proteins (BMPs) involve the R-Smad family members Smad1, Smad5, Smad8 and the Co-Smad, Smad4. Smads are currently considered to be DNA-binding trans...

    Authors: Yin Lin, Jennifer Martin, Cornelia Gruendler, Jennifer Farley, Xianwang Meng, Bi-Yu Li, Robert Lechleider, Carla Huff, Richard H Kim, William Grasser, Vishwas Paralkar and Tongwen Wang

    Citation: BMC Cell Biology 2002 3:15

    Content type: Methodology article

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  9. Growth of cancer cells results from the disturbance of positive and negative growth control mechanisms and the prolonged survival of these genetically altered cells due to the failure of cellular suicide progr...

    Authors: Véronique Le Mellay, Jakob Troppmair, Roland Benz and Ulf R Rapp

    Citation: BMC Cell Biology 2002 3:14

    Content type: Research article

    Published on:

  10. During wound repair, fibroblasts orchestrate replacement of the provisional matrix formed during clotting with tenascin, cellular fibronectin and collagen III. These, in turn, are critical for migration of end...

    Authors: Jo Ellen Feugate, Lina Wong, Qi-Jing Li and Manuela Martins-Green

    Citation: BMC Cell Biology 2002 3:13

    Content type: Research article

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  11. Elevated plasma counts of endothelial microparticles (MP) have been demonstrated in various diseases with a vascular injury component. We used flow cytometry to study the MP-release from cultured human umbilic...

    Authors: Jan Šimák, Karel Holada and Jaroslav G Vostal

    Citation: BMC Cell Biology 2002 3:11

    Content type: Research article

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  12. Liver fibrosis is the common sequel of chronic liver diseases. Recent studies have identified hepatic stellate cells as the primary cell type mediating hepatic fibrogenesis. It has been demonstrated that hepat...

    Authors: Hong Shen, Manna Zhang, Gerald Y Minuk and Yuewen Gong

    Citation: BMC Cell Biology 2002 3:9

    Content type: Research article

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  13. Liver sinusoidal endothelial cells (LSECs) react to different anti-actin agents by increasing their number of fenestrae. A new structure related to fenestrae formation could be observed when LSECs were treated...

    Authors: Filip Braet, Ilan Spector, Nava Shochet, Phillip Crews, Tatsuo Higa, Eline Menu, Ronald de Zanger and Eddie Wisse

    Citation: BMC Cell Biology 2002 3:7

    Content type: Research article

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  14. A number of transcription factors coordinate differentiation by simultaneously regulating gene expression and cell proliferation. CCAAT/enhancer binding protein alpha (C/EBPα) is a basic/leucine zipper transcr...

    Authors: Weiqun Liu, John F Enwright III, William Hyun, Richard N Day and Fred Schaufele

    Citation: BMC Cell Biology 2002 3:6

    Content type: Research article

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  15. Previous studies have shown that several agents that stimulate heptahelical G-protein coupled receptors activate the extracellular signal regulated kinases ERK1 (p44mapk) and ERK2 (p42mapk) in hepatocytes. The mo...

    Authors: Øyvind Melien, Laila S Nilssen, Olav F Dajani, Kristin Larsen Sand, Jens-Gustav Iversen, Dagny L Sandnes and Thoralf Christoffersen

    Citation: BMC Cell Biology 2002 3:5

    Content type: Research article

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  16. The membrane-bound cell-surface precursor and soluble forms of heparin-binding epidermal growth factor-like growth factor (HB-EGF) contribute to many cellular developmental processes. The widespread occurrence...

    Authors: Joanna S Brooke, Jeong-Heon Cha and Leon Eidels

    Citation: BMC Cell Biology 2002 3:2

    Content type: Research article

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  17. Patients with Opitz GBBB syndrome present with a variable array of developmental defects including craniofacial, cardiac, and genital anomalies. Mutations in the X-linked MID1 gene, which encodes a microtubule-bi...

    Authors: Kieran M Short, Blair Hopwood, Zou Yi and Timothy C Cox

    Citation: BMC Cell Biology 2002 3:1

    Content type: Research article

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  18. Many eukaryotes, including plants and fungi make spores that resist severe environmental stress. The micro-organism Dictyostelium contains a single phospholipase C gene (PLC); deletion of the gene has no effect o...

    Authors: Peter Van Dijken and Peter JM Van Haastert

    Citation: BMC Cell Biology 2001 2:25

    Content type: Research article

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  19. Structural requirements for the β1 integrin functions in cell adhesion, spreading and signaling have been well documented mainly for fibroblasts. In this study, we examined the reason for the reduced surface e...

    Authors: Kazuhide Takahashi

    Citation: BMC Cell Biology 2001 2:23

    Content type: Research article

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  20. Luteinizing hormone secreted by the anterior pituitary gland regulates gonadal function. Luteinizing hormone secretion is regulated both by alterations in gonadotrope responsiveness to hypothalamic gonadotropi...

    Authors: Jimmy D Neill, L Wayne Duck, Jeffrey C Sellers, Lois C Musgrove and John H Kehrl

    Citation: BMC Cell Biology 2001 2:21

    Content type: Research article

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  21. During apoptosis, Ca2+-dependent events participate in the regulation of intracellular and morphological changes including phosphatidylserine exposure in the exoplasmic leaflet of the cell plasma membrane. The oc...

    Authors: M Carmen Martínez and Jean-Marie Freyssinet

    Citation: BMC Cell Biology 2001 2:20

    Content type: Research article

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  22. The first type III repeat of fibronectin is known to be involved in fibronectin matrix assembly, and recombinant proteins from this type III repeat can inhibit cell proliferation, tumor metastasis and angiogen...

    Authors: Kwesi O Mercurius and Alex O Morla

    Citation: BMC Cell Biology 2001 2:18

    Content type: Research article

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  23. Although MP20 is the second most highly expressed membrane protein in the lens its function remains an enigma. Putative functions for MP20 have recently been inferred from its assignment to the tetraspanin sup...

    Authors: Tamir Gonen, Angus C Grey, Marc D Jacobs, Paul J Donaldson and Joerg Kistler

    Citation: BMC Cell Biology 2001 2:17

    Content type: Research article

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  24. SPARC is a matricellular protein involved in cell-matrix interactions. From expression patterns at the wound site and in vitro studies, SPARC has been implicated in the control of wound healing. Here we examin...

    Authors: Amitabha Basu, Lorraine H Kligman, Stefan J Samulewicz and Chin C Howe

    Citation: BMC Cell Biology 2001 2:15

    Content type: Research article

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  25. The tissue accumulation of protein-bound advanced glycation endproducts (AGE) may be involved in the etiology of diabetic chronic complications, including osteopenia. The aim of this study was to investigate t...

    Authors: Antonio D McCarthy, Susana B Etcheverry, Liliana Bruzzone, Gabriela Lettieri, Daniel A Barrio and Ana M Cortizo

    Citation: BMC Cell Biology 2001 2:16

    Content type: Research article

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  26. Bone morphogenetic proteins (BMPs) and transforming growth factor-βs (TGF-βs) are important regulators of bone repair and regeneration. BMP-2 and TGF-β1 have been shown to inhibit gap junctional intercellular ...

    Authors: Lance E Wyatt, Chi Y Chung, Brian Carlsen, Akiko Iida-Klein, George H Rudkin, Kenji Ishida, Dean T Yamaguchi and Timothy A Miller

    Citation: BMC Cell Biology 2001 2:14

    Content type: Research article

    Published on:

  27. Filopodia, retraction fibers and microvilli, are fragile microextensions of the plasma membrane that are easily damaged by mechanical force during specimen preparation for microscopy. To preserve these structu...

    Authors: Fumihiko Nakamura

    Citation: BMC Cell Biology 2001 2:10

    Content type: Research article

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  28. Dictyostelium cells exhibit an unusual response to hyperosmolarity that is distinct from the response in other organisms investigated: instead of accumulating compatible osmolytes as it has been described for a w...

    Authors: Tanja Pintsch, Michel Satre, Gérard Klein, Jean-Baptiste Martin and Stephan C Schuster

    Citation: BMC Cell Biology 2001 2:9

    Content type: Research article

    Published on:

  29. Dimerization is an important regulatory mechanism of single membrane-spanning receptors. For instance, activation of receptor protein-tyrosine kinases (RPTKs) involves dimerization. Structural, functional and ...

    Authors: Leon GJ Tertoolen, Christophe Blanchetot, Guoqiang Jiang, John Overvoorde, Theodorus WJ Gadella Jr, Tony Hunter and Jeroen den Hertog

    Citation: BMC Cell Biology 2001 2:8

    Content type: Research article

    Published on:

  30. Ethylene is a widely distributed alkene product which is formed enzymatically (e.g., in plants) or by photochemical reactions (e.g., in the upper oceanic layers from dissolved organic carbon). This gaseous com...

    Authors: Sanja Perovic, Jürgen Seack, Vera Gamulin, Werner EG Müller and Heinz C Schröder

    Citation: BMC Cell Biology 2001 2:7

    Content type: Research article

    Published on:

  31. In most cells glucocorticoid receptors (GR) reside predominately in the cytoplasm. Upon hormone binding, the GR translocates into the nucleus, where the hormone-activated GR-complex regulates the transcription...

    Authors: David A Dean, Gudrun Urban, Ileana V Aragon, Mark Swingle, Beth Miller, Sandro Rusconi, Manuel Bueno, Nicholas M Dean and Richard E Honkanen

    Citation: BMC Cell Biology 2001 2:6

    Content type: Research article

    Published on:

  32. Numerous investigations demonstrate a novel role of thyroid hormone as a modulator of signal transduction. Protein kinase C (PKC) is critical to the mechanism by which thyroid hormones potentiate both the anti...

    Authors: Nataliya S Kavok, Oksana A Krasilnikova and Nataliya A Babenko

    Citation: BMC Cell Biology 2001 2:5

    Content type: Research article

    Published on:

  33. A breakthrough in the understanding of centriole assembly was provided by the characterization of the UNI3 gene in Chlamydomonas. Deletion of this gene, found to encode a novel member of the tubulin superfamily, ...

    Authors: Nicole Garreau de Loubresse, Françoise Ruiz, Janine Beisson and Catherine Klotz

    Citation: BMC Cell Biology 2001 2:4

    Content type: Research article

    Published on:

  34. Although the role of the osteoclast in bone resorption is becoming better understood, much remains to be learned about osteoclastogenesis and the exact mechanism of action of anti-resorbing agents such as 17β-...

    Authors: Helen E Gruber, Igor J Puzanov, Michael Bennett, Vinay Kumar and Brian Gordon

    Citation: BMC Cell Biology 2001 2:3

    Content type: Research article

    Published on:

  35. Aside from muscle, brain is also a major expression site for dystrophin, the protein whose abnormal expression is responsible for Duchenne muscular dystrophy. Cognitive impairments are frequently associated wi...

    Authors: Kevin Culligan, Louise Glover, Paul Dowling and Kay Ohlendieck

    Citation: BMC Cell Biology 2001 2:2

    Content type: Research article

    Published on:

2018 Journal Metrics

  • Citation Impact

    3.485 - 2-year Impact Factor
    3.227 - 5-year Impact Factor
    0.857 - Source Normalized Impact per Paper (SNIP)
    1.403 - SCImago Journal Rank (SJR)

    Usage 
    681,235 downloads


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