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  1. Hydrogen-rich water (HRW) has been shown to prevent cognitive impairment caused by ionizing radiation. This study aimed to investigate the pharmacological effects and mechanisms of HRW on ionizing radiation by...

    Authors: Xiaoming Liu, Mengya Liu, Huan Liu, Hui Yuan, Yong Wang, Xiaoman Chen, Jianguo Li and Xiujun Qin
    Citation: BMC Molecular and Cell Biology 2023 24:30
    Content type: Research Published on:

  3. Inflammation plays a crucial role in the progression of Subacute Ruminal Acidosis (SARA). The experiment was designed to investigate anti-inflammatory effects of glycyrrhizin on goats ruminal epithelial cells ...

    Authors: Junfeng Liu, Bei Ma, Guang Hao, DuoDuo Su, Tianyang Wang, Ze Ding and Xuefeng Guo
    Citation: BMC Molecular and Cell Biology 2023 24:28
    Content type: Research Published on:

  4. Age-related hearing loss, known as presbycusis, is the result of auditory system degeneration. Numerous studies have suggested that reactive oxygen species (ROS) and mitochondrial oxidative damage play importa...

    Authors: Zhe Peng, Chunli Zhao, Zijing Yang, Shusheng Gong and Zhengde Du
    Citation: BMC Molecular and Cell Biology 2023 24:27
    Content type: Research Published on:

  5. Heterogeneous nuclear ribonucleoprotein K (HNRNPK) regulates pre-mRNA processing and long non-coding RNA localization in the nucleus. It was previously shown that shuttling of HNRNPK to the cytoplasm promotes ...

    Authors: Arwa Fallatah, Dimitrios G. Anastasakis, Amirhossein Manzourolajdad, Pooja Sharma, Xiantao Wang, Alexis Jacob, Sarah Alsharif, Ahmed Elgerbi, Pierre A. Coulombe, Markus Hafner and Byung Min Chung
    Citation: BMC Molecular and Cell Biology 2023 24:26
    Content type: Research Published on:

  7. Bone morphogenetic protein 9 (BMP9) has been shown to regulate processes such as angiogenesis, endothelial dysfunction, and tumorigenesis. However, the role of BMP9 in preeclampsia (PE) is unclear. The purpose...

    Authors: Xue Yang, Lingling Ren, Xiang Chen, Ying Pang, Baoxia Jia, Jing Sun and Xiaofang Quan
    Citation: BMC Molecular and Cell Biology 2023 24:24
    Content type: Research Published on:

  8. Emodin and aloe-emodin are two anthraquinones having positive effects in wound healing. However, their mechanism of action of wound healing is not fully understood. The MAP kinase family, which plays an active...

    Authors: Aysenur Gunaydin-Akyildiz, Rabia Sare Yanikoglu, Meltem Gulec, Gulbahar Ozge Alim-Toraman, Ebru Didem Kuran, Sezen Atasoy, Abdullah Olgun and Gulacti Topcu
    Citation: BMC Molecular and Cell Biology 2023 24:23
    Content type: Research Published on:

  9. Renal ischemia/reperfusion (I/R) injury is a major cause of acute kidney injury (AKI). Dysfunction of E74-like ETS transcription factor 4 (ELF4) leads to inflammation. This research intended to look into the f...

    Authors: Li Li, Shunying Wang and Wenming Wang
    Citation: BMC Molecular and Cell Biology 2023 24:22
    Content type: Research Published on:

  10. Janus kinase 3 (JAK3) is a member of the JAK family of tyrosine kinase proteins involved in cytokine receptor-mediated intracellular signal transduction through the JAK/STAT signaling pathway. JAK3 was previou...

    Authors: Amir Zareifard, Francis Beaudry and Kalidou Ndiaye
    Citation: BMC Molecular and Cell Biology 2023 24:21
    Content type: Research article Published on:

  11. DYX1C1 (DNAAF4) and DCDC2 are two of the most replicated dyslexia candidate genes in genetic studies. They both have demonstrated roles in neuronal migration, in cilia growth and function and they both are cytosk...

    Authors: Andrea Bieder, Gayathri Chandrasekar, Arpit Wason, Steffen Erkelenz, Jay Gopalakrishnan, Juha Kere and Isabel Tapia-Páez
    Citation: BMC Molecular and Cell Biology 2023 24:20
    Content type: Research article Published on:

  12. The platelet-derived growth factor (PDGF) family of ligands exerts their cellular effects by binding to α- and β-tyrosine kinase receptors (PDGFRα and PDGFRβ, respectively). SUMOylation is an important posttra...

    Authors: Kehuan Wang, Natalia Papadopoulos, Anahita Hamidi, Johan Lennartsson and Carl-Henrik Heldin
    Citation: BMC Molecular and Cell Biology 2023 24:19
    Content type: Research Published on:

  13. For the purpose of skeletal muscle engineering, primary myoblasts (Mb) and adipogenic mesenchymal stem cells (ADSC) can be co-cultured and myogenically differentiated. Electrospun composite nanofiber scaffolds...

    Authors: Aijia Cai, Paul Schneider, Zeng-Ming Zheng, Justus P. Beier, Marcus Himmler, Dirk W. Schubert, Volker Weisbach, Raymund E. Horch and Andreas Arkudas
    Citation: BMC Molecular and Cell Biology 2023 24:18
    Content type: Research Published on:

  14. Cytochrome P450 4F2 (CYP4F2) enzyme is a member of the CYP4 family responsible for the metabolism of fatty acids, therapeutic drugs, and signaling molecules such as arachidonic acid, tocopherols, and vitamin K...

    Authors: Mahvash Farajzadeh-Dehkordi, Ladan Mafakher, Fatemeh Samiee-Rad and Babak Rahmani
    Citation: BMC Molecular and Cell Biology 2023 24:17
    Content type: Research Published on:

  15. Hypoxic culture conditions have been used to study the impact of oxygen deprivation has on gene expression in a number of disease models. However, hypoxia response elements present in the promoter regions of s...

    Authors: Huan Ting Ong, Cecilia M. Prêle and Rodney J. Dilley
    Citation: BMC Molecular and Cell Biology 2023 24:16
    Content type: Research Published on:

  16. Nasopharyngeal carcinoma is a tumor with high malignancy and poor prognosis, which severely affects the health of the patients. LncRNAs and microRNAs are crucial for the occurrence and development of nasophary...

    Authors: Chunmao Jiang, Dandan Feng, Yu Zhang, Kun Yang, Xiaotong Hu and Qian Xie
    Citation: BMC Molecular and Cell Biology 2023 24:15
    Content type: Research Published on:

  17. Recent studies have reported that the circadian transcription factor aryl hydrocarbon receptor nuclear translocator like 2 (ARNTL2) promotes the metastatic progression of lung adenocarcinoma. However, the mole...

    Authors: Tao Wang, Kai Wang, Xu Zhu and Nan Chen
    Citation: BMC Molecular and Cell Biology 2023 24:14
    Content type: Research Published on:

  18. Human accelerated regions (HARs) are short conserved genomic sequences that have acquired significantly more nucleotide substitutions than expected in the human lineage after divergence from chimpanzees. The f...

    Authors: Hizran Khatoon, Rabail Zehra Raza, Shoaib Saleem, Fatima Batool, Saba Arshad, Muhammad Abrar, Shahid Ali, Irfan Hussain, Neil H. Shubin and Amir Ali Abbasi
    Citation: BMC Molecular and Cell Biology 2023 24:13
    Content type: Research article Published on:

  19. Endometriosis cause decreases in life quality and pelvic pain in reproductive-age women. Methylation abnormalities played a functional role in the progression of endometriosis, this study aimed to explore the ...

    Authors: Mei Yang, Lin Li, Xiaojie Huang, Hui Xing, Li Hong and Chunfan Jiang
    Citation: BMC Molecular and Cell Biology 2023 24:12
    Content type: Research Published on:

  20. Type I Diabetes mellitus (T1D) is characterized by a specific destruction of β-cells by the immune system. During this process pro-inflammatory cytokines are released in the pancreatic islets and contribute for β...

    Authors: V. R. Oliveira, C. C. Paula, S. Taniguchi and F. Ortis
    Citation: BMC Molecular and Cell Biology 2023 24:11
    Content type: Research Published on:

  21. Hypoxia is considered a critical contributor to renal cell carcinoma progression, including invasion and metastasis. However, the potential mechanisms by which it promotes invasion and metastasis have not yet ...

    Authors: Jing Shi, Ruili Sha and Xilan Yang
    Citation: BMC Molecular and Cell Biology 2023 24:10
    Content type: Research Published on:

  23. This study was designed to investigate to test the effect of exosomes from urine-derived mesenchymal stem cells (USCs) on the survival and viability of aging retinal ganglion cells (RGCs), and explored the pre...

    Authors: Qi-Qin Dan, Li Chen, Lan-Lan shi, Xiu Zhou, Ting-Hua Wang and Hua Liu
    Citation: BMC Molecular and Cell Biology 2023 24:8
    Content type: Research Published on:

  24. Abnormal biogenesis and ribosome free function of ribosomal proteins (RPs) is important for tumorgenesis and development. Ribosomal protein L11 (RPL11) is a component of ribosomal 60 S large subunit with diffe...

    Authors: Jie Chen, Changda Lei, Huahua Zhang, Xiaoyong Huang, Yang Yang, Junli Liu, Yuna Jia, Haiyan Shi, Yunqing Zhang, Jing Zhang and Juan Du
    Citation: BMC Molecular and Cell Biology 2023 24:7
    Content type: Research Published on:

  25. Delta-9-tetrahydrocannabinol (THC) is the primary phytocannabinoid responsible for the psychoactive properties of cannabis and is known to interact with the endocannabinoid system, which is functionally presen...

    Authors: Vivien B. Truong, Ola S. Davis, Jade Gracey, Michael S. Neal, Jibran Y. Khokhar and Laura A. Favetta
    Citation: BMC Molecular and Cell Biology 2023 24:6
    Content type: Research Published on:

  26. Melanoma is the most lethal type of skin cancer that originates from the malignant transformation of melanocytes. Although novel treatments have improved patient survival in melanoma, the overall prognosis rem...

    Authors: Zahra Malakoutikhah, Zahra Mohajeri, Nasim Dana and Shaghayegh Haghjooy Javanmard
    Citation: BMC Molecular and Cell Biology 2023 24:5
    Content type: Research Published on:

  27. Bronchopulmonary dysplasia is a serious and lifelong pulmonary disease in premature neonates that influences around one-quarter of premature newborns. The wingless-related integration site /β-catenin signaling...

    Authors: Yuting Zhu, Yawen Li, Weilai Jin, Zhengying Li, Le Zhang, Yuanyuan Fang and Yanyu Zhang
    Citation: BMC Molecular and Cell Biology 2023 24:4
    Content type: Research Published on:

  28. Alterations in vascular smooth muscle cells (VSMCs) contribute to the pathogenesis of intracranial aneurysms (IAs). However, molecular mechanisms underlying these changes remain unknown. The present study aime...

    Authors: Jichong Xu and Chun Fang
    Citation: BMC Molecular and Cell Biology 2023 24:3
    Content type: Research Published on:

  29. Autophagy and pyroptosis of macrophages play important protective or detrimental roles in sepsis. However, the underlying mechanisms remain unclear. High mobility group box protein 1 (HMGB1) is associated with...

    Authors: Jiawei Shang, Feng Zhao, Yongmei Cao, Feng Ping, Wei Wang and Yingchuan Li
    Citation: BMC Molecular and Cell Biology 2023 24:2
    Content type: Research Published on:

  30. Tendon injury is associated with oxidative stress, leading to reactive oxygen species (ROS) production and inflammation. N-acetyl-L-cysteine (NAC) is a potent antioxidant. However, how NAC affects the biologic...

    Authors: Kang Lu, Mei Zhou, Liyuan Wang, Yang Wang, Hong Tang, Gang He, Huan Wang, Chuyue Tang, Jie He, Wei Wang, Kanglai Tang, Yunjiao Wang and Zhongliang Deng
    Citation: BMC Molecular and Cell Biology 2023 24:1
    Content type: Research Published on:

  31. Considering the high correlation between the functional decline in Alzheimer’s disease (AD) and the propagation of aggregated tau protein, many research efforts are focused on determining the underlying molecu...

    Authors: Andreia Ferreira, Ines Royaux, Jian Liu, Zhangjie Wang, Guowei Su, Diederik Moechars, Nico Callewaert and Louis De Muynck
    Citation: BMC Molecular and Cell Biology 2022 23:61
    Content type: Research Published on:

  34. Cold inducible RNA-binding protein (CIRP) is a key protein in the hypothermic therapy. Highly expressed CIRP exerts a neuroprotective effect on neurons. The aim of this study is to provide the evidence of the ...

    Authors: Aijun Liu, Shouchun Li, Yongcheng Jiao, Haibo Kong and Zhiwen Zhang
    Citation: BMC Molecular and Cell Biology 2022 23:58
    Content type: Research Published on:

  36. Magnolia, a traditional and important ornamental plant in urban greening, has been cultivated for about 2000 years in China for its elegant flower shape and gorgeous flower color. Most varieties of Magnolia bloom...

    Authors: Lingjuan Xuan, Qianqian Wang, Zhigao Liu, Bin Xu, Shaoyu Cheng, Yingjia Zhang, Danying Lu, Bin Dong, Dongmei Zhang, Lang Zhang, Jingjing Ma and Yamei Shen
    Citation: BMC Molecular and Cell Biology 2022 23:56
    Content type: Research Published on:

  37. Doxorubicin (DOX), which is widely used in cancer treatment, can induce cardiomyopathy. One of the main mechanisms whereby DOX induces cardiotoxicity involves pyroptosis through the NLR family pyrin domain con...

    Authors: Soyoung Hwang, Se-Hee Kim, Kwai Han Yoo, Myung-Hee Chung, Jin Woo Lee and Kuk Hui Son
    Citation: BMC Molecular and Cell Biology 2022 23:55
    Content type: Research Published on:

  38. Pyroptosis of endothelial cells is a new cause of endothelial dysfunction in multiple diseases. Ceramide acts as a potential bioactive mediator of inflammation and increases vascular endothelial permeability i...

    Authors: Fangfang Liu, Yangyang Zhang, Yining Shi, Kai Xiong, Fugui Wang and Jin Yang
    Citation: BMC Molecular and Cell Biology 2022 23:54
    Content type: Research Published on:

  39. Placement of a cultured synovial mesenchymal stem cell (MSC) suspension on a repaired meniscus for 10 min accelerated meniscus repair. Upon placement of the MSC suspension on the meniscus, microspikes projecti...

    Authors: Shunichi Fujii, Kentaro Endo, Nobutake Ozeki, Yuriko Sakamaki, Yuji Kohno, Mitsuru Mizuno, Hisako Katano, Kunikazu Tsuji, Hideyuki Koga and Ichiro Sekiya
    Citation: BMC Molecular and Cell Biology 2022 23:53
    Content type: Research article Published on:

  40. Keloid is a benign proliferative fibrous disease featured by excessive fibroblast proliferation after skin injury. However, the mechanism of abnormal cell proliferation is still unclear. Herein, we investigate...

    Authors: Hanye Liu, Guanghai Yan, Li Li, Dandan Wang, Yu Wang, Shan Jin, Zhehu Jin, Liangchang Li and Lianhua Zhu
    Citation: BMC Molecular and Cell Biology 2022 23:52
    Content type: Research Published on:

  41. To establish castration-resistant prostate cancer (CRPC) - Lncap androgen-independent (AI) cell line from Lncap androgen-dependent (AD) cell line, and explore the different molecular biological between these t...

    Authors: Huifeng Wang, Xihua Wei, Die Zhang, Weidong Li and Yanling Hu
    Citation: BMC Molecular and Cell Biology 2022 23:51
    Content type: Research Published on:

  42. The present study aims to explore the correlation of the transforming growth factor β (TGF-β), drosophila mothers against decapentaplegic protein gene (SMAD) 2/3/4, and leukemia inhibitory factors (LIF) with t...

    Authors: Shuang-li Qin, Yun Guo, Shui-Xue Li, Ling Zhou, Azguli Maimaiti, Yusufu Akemu, Jun He and Hai-Xia Yao
    Citation: BMC Molecular and Cell Biology 2022 23:50
    Content type: Research Published on:

  44. Abnormal expression of ribosomal proteins has an important regulatory effect on the progression of cancer. RPL5 is involved in the progression of various malignancies, however, the role of RPL5 in colon cancer...

    Authors: Huahua Zhang, Junli Liu, Qingqing Dang, Xueru Wang, Jie Chen, Xiaoyin Lin, Na Yang, Juan Du, Haiyan Shi, Yong Liu and Jiming Han
    Citation: BMC Molecular and Cell Biology 2022 23:48
    Content type: Research Published on:

  45. Although hormonal and metabolic dysfunction have been recognized as a possible cause of polycystic ovarian syndrome (PCOS), the associations between hyperandrogenism and aryl hydrocarbon receptor (Ahr) signali...

    Authors: Fatemeh Eini, Maryam Azizi kutenaei, Tahereh Foroutan and Ensieh Salehi
    Citation: BMC Molecular and Cell Biology 2022 23:47
    Content type: Research Published on:

  46. Cholangiocarcinoma is a kind of invasive malignant tumor followed by hepatocellular carcinoma. miR-451 was suggested to function as regulator in various human tumors, but its role in mediating tumor progressio...

    Authors: Dengfang Guo, Qingling Wang, Jiancheng Huang, Zhanglin Hu, Chun Chen, Chun Zhang and Feng Lin
    Citation: BMC Molecular and Cell Biology 2022 23:46
    Content type: Research Published on:

  47. Acetaminophen is commonly recommended for the early analgesia of osteoarthritis. However, the molecular mechanism by which it acts remains unknown. The aim of this study is to investigate the effect of acetami...

    Authors: Jie Gao, Yan Li, Zijin Liu, Dong Wang and Huawu Zhang
    Citation: BMC Molecular and Cell Biology 2022 23:45
    Content type: Research Published on:

  48. Cervical cancer is an important malignant tumor threatening the physical and mental health of women in the world. As a new calcium activated chloride channel protein, calcium activated chloride channel (CLCA2) pl...

    Authors: Wenhu Xin, Jian Zhang, Haibin Zhang, Xueyao Ma, Yunzhong Zhang, Yufeng Li and Fang Wang
    Citation: BMC Molecular and Cell Biology 2022 23:44
    Content type: Research Published on:

  49. The cranial region is a complex set of blood vessels, cartilage, nerves and soft tissues. The reconstruction of cranial defects caused by trauma, congenital defects and surgical procedures presents clinical ch...

    Authors: Yang Liu, Pingping Niu, Mengqi Zhou and Hui Xue
    Citation: BMC Molecular and Cell Biology 2022 23:43
    Content type: Research Published on:

  50. COVID-19 is a disease caused by SARS-CoV-2, which can cause mild to serious infections in humans. We aimed to explore the effect of growth hormone (GH)/estrogen/androgen in normal human lung epithelial BEAS-2B...

    Authors: Zemin Zhu, Zhijian Zhao, Xun Chen, Zhou Chu, Yi He, Yingzheng Tan, Juan Zhou and Caixi Tang
    Citation: BMC Molecular and Cell Biology 2022 23:42
    Content type: Research Published on:
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BMC Molecular and Cell Biology

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