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  1. Long noncoding RNAs (lncRNAs) are recently found to be critical regulators of the epigenome. However, our knowledge of their role in osteoarthritis (OA) development is limited. This study investigates the mech...

    Authors: Yang Yang, Dan Xing, Yawei Wang, Haobo Jia, Bing Li and Jiao Jiao Li

    Citation: BMC Molecular and Cell Biology 2020 21:53

    Content type: Research article

    Published on:

  2. The main challenge in cancer research is the identification of different omic variables that present a prognostic value and personalised diagnosis for each tumour. The fact that the diagnosis is personalised o...

    Authors: Jose Liñares-Blanco, Cristian R. Munteanu, Alejandro Pazos and Carlos Fernandez-Lozano

    Citation: BMC Molecular and Cell Biology 2020 21:52

    Content type: Research article

    Published on:

  4. Β-glucosidases are key enzymes used in second-generation biofuel production. They act in the last step of the lignocellulose saccharification, converting cellobiose in glucose. However, most of the β-glucosida...

    Authors: Diego Mariano, Naiara Pantuza, Lucianna H. Santos, Rafael E. O. Rocha, Leonardo H. F. de Lima, Lucas Bleicher and Raquel Cardoso de Melo-Minardi

    Citation: BMC Molecular and Cell Biology 2020 21:50

    Content type: Database

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  5. Following the recent outbreak of the new coronavirus pandemic (Covid-19), the rapid determination of the structure of the homo-trimeric spike glycoprotein has prompted the study reported here. The aims were to...

    Authors: Elliot D. Drew and Robert W. Janes

    Citation: BMC Molecular and Cell Biology 2020 21:49

    Content type: Research article

    Published on:

  6. Colorectal cancer (CRC) is a leading cancer and a major cause of death. Lipopolysaccharide (LPS), an abundant component in gut microbiome, is involved in CRC progression and metastasis, potentially through reg...

    Authors: Yimei Jiang, Xiaopin Ji, Kun Liu, Yiqing Shi, Changgang Wang, You Li, Tao Zhang, Yonggang He, Ming Xiang and Ren Zhao

    Citation: BMC Molecular and Cell Biology 2020 21:48

    Content type: Research article

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  7. Chondrocytes are exposed to an inflammatory micro-environment in the extracellular matrix (ECM) of articular cartilage in joint diseases such as osteoarthritis (OA) and rheumatoid arthritis (RA). In OA, degene...

    Authors: Bernadette Jeremiasse, Csaba Matta, Christopher R. Fellows, David J. Boocock, Julia R. Smith, Susan Liddell, Floris Lafeber, Willem E. van Spil and Ali Mobasheri

    Citation: BMC Molecular and Cell Biology 2020 21:47

    Content type: Research article

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  8. Drug resistance is a severe problem in HIV treatment. HIV protease is a common target for the design of new drugs for treating HIV infection. Previous studies have shown that the crystallographic structures of...

    Authors: Pierre Laville, Sandrine Fartek, Natacha Cerisier, Delphine Flatters, Michel Petitjean and Leslie Regad

    Citation: BMC Molecular and Cell Biology 2020 21:46

    Content type: Research article

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  9. Klotho is a multifunctional protein, which exists both in a membrane bound and a soluble form. In renal tubules, Klotho is involved in cell senescence, anti-oxidant response, and renal fibrosis, thus regulatio...

    Authors: Yan Li, Yong Liu, Kailong Wang, Yinghui Huang, Wenhao Han, Jiachuan Xiong, Ke Yang, Mingying Liu, Tangli Xiao, Chi Liu, Ting He, Xianjin Bi, Jingbo Zhang, Bo Zhang and Jinghong Zhao

    Citation: BMC Molecular and Cell Biology 2020 21:45

    Content type: Research article

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  10. Trace elements function as essential cofactors that are involved in various biochemical processes in mammals. Autophagy is vital for nutrient supplement, which is an important Zeitegber for the circadian homeosta...

    Authors: Yicheng Jiang, Yang Gu, Hai Xu, Xiaoyi Tian, Xuefeng Zhang, Xiaojin Xu, Wenting Yan and Xiwen Zhang

    Citation: BMC Molecular and Cell Biology 2020 21:44

    Content type: Research article

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  11. Growth-temperature stress causes biochemical changes in the cells and reduction of biomass yield. Quantitative proteome of Arthrospira platensis C1 in response to low- and high temperature stresses was previously...

    Authors: Pavinee Kurdrid, Phutnichar Phuengcharoen, Jittisak Senachak, Sirilak Saree and Apiradee Hongsthong

    Citation: BMC Molecular and Cell Biology 2020 21:43

    Content type: Research article

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  12. Stress is an important cause of skin disease, including hair loss. The hormonal response to stress is due to the HPA axis, which comprises hormones such as corticotropin releasing factor (CRF), adrenocorticotr...

    Authors: Eun Young Lee, You Jin Nam, Sangjin Kang, Eun Ju Choi, Inbo Han, Jinwan Kim, Dong Hyun Kim, Ji Hae An, Sunghou Lee, Min Ho Lee and Ji Hyung Chung

    Citation: BMC Molecular and Cell Biology 2020 21:42

    Content type: Research article

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  13. Localization of neurokinin 1 receptor (NK1R), the endogenous receptor for neuropeptide substance P (SP), has already been described for the right atrium (RA) of the heart. However, the biological role of SP/NK1R ...

    Authors: Yun-Mi Jeong, Xian Wu Cheng, Kyung Hye Lee, Sora Lee, Haneul Cho and Weon Kim

    Citation: BMC Molecular and Cell Biology 2020 21:41

    Content type: Research article

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  14. In the poultry and livestock industries, precise genetic information is crucial for improving economic traits. Thus, functional genomic studies help to generate faster, healthier, and more efficient animal pro...

    Authors: Jeong Hyo Lee, Seo Woo Kim, Ji Seon Han, Seung Pyo Shin, Sang In Lee and Tae Sub Park

    Citation: BMC Molecular and Cell Biology 2020 21:40

    Content type: Research article

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  15. Members of the T-box family of DNA-binding proteins play a prominent role in the differentiation of the three primary germ layers. VegT, Brachyury, and Eomesodermin function as transcriptional activators and, ...

    Authors: Shoshana Reich, Peter Kayastha, Sushma Teegala and Daniel C. Weinstein

    Citation: BMC Molecular and Cell Biology 2020 21:39

    Content type: Research article

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  16. Detailed structural knowledge of enzyme-inhibitor complexes trapped in intermediate state is the key for a fundamental understanding of reaction mechanisms taking place in enzymes and is indispensable as a str...

    Authors: Peter Agback, Esmeralda Woestenenk and Tatiana Agback

    Citation: BMC Molecular and Cell Biology 2020 21:38

    Content type: Research article

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  17. To establish a metabolite fingerprint of ossification of the thoracic ligamentum flavum (OTLF) patients using liquid chromatography-mass spectrometry (LC-MS) in combination with transcriptomic data and explore...

    Authors: Jiahao Li, Lingjia Yu, Shigong Guo and Yu Zhao

    Citation: BMC Molecular and Cell Biology 2020 21:37

    Content type: Research article

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  18. The SMC5/6 complex, cohesin and condensin are the three mammalian members of the structural maintenance of chromosomes (SMC) family, large ring-like protein complexes that are essential for genome maintenance....

    Authors: András Horváth, Gergely Rona, Michele Pagano and Philip W. Jordan

    Citation: BMC Molecular and Cell Biology 2020 21:36

    Content type: Research article

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  19. Fluorescence microscopy is a powerful tool in cell biology, especially for the study of dynamic processes. Intensive irradiation of bacteria with UV, blue and violet light has been shown to be able to kill cel...

    Authors: Nina El Najjar, Muriel C. F. van Teeseling, Benjamin Mayer, Silke Hermann, Martin Thanbichler and Peter L. Graumann

    Citation: BMC Molecular and Cell Biology 2020 21:35

    Content type: Research article

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  20. Deficiency in thymidine kinase 2 (TK2) or p53 inducible ribonucleotide reductase small subunit (p53R2) is associated with tissue specific mitochondrial DNA (mtDNA) depletion. To understand the mechanisms of th...

    Authors: Liya Wang, Ren Sun and Staffan Eriksson

    Citation: BMC Molecular and Cell Biology 2020 21:33

    Content type: Research article

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  21. Neutral cholesterol ester hydrolase 1 (NCEH1) catalyzes the hydrolysis of cholesterol ester (CE) in macrophages. Genetic ablation of NCEH1 promotes CE-laden macrophages and the development of atherosclerosis i...

    Authors: Hiroshi Matsuoka, Riki Tokunaga, Miyu Katayama, Yuichiro Hosoda, Kaoruko Miya, Kento Sumi, Ami Ohishi, Jun Kamishikiryo, Akiho Shima and Akihiro Michihara

    Citation: BMC Molecular and Cell Biology 2020 21:32

    Content type: Research article

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  22. Cytoprotection afforded by mitochondrial ATP-sensitive K+-channel (mKATP-channel) opener diazoxide (DZ) largely depends on the activation of potassium cycle with eventual modulation of mitochondrial functions and...

    Authors: Olga Akopova, Liudmila Kolchinskaya, Valentina Nosar, Iryna Mankovska and Vadim Sagach

    Citation: BMC Molecular and Cell Biology 2020 21:31

    Content type: Research article

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  23. Transmembrane and immunoglobulin domain-containing protein 1 (TMIGD1) is a recently identified cell adhesion molecule which is predominantly expressed by epithelial cells of the intestine and the kidney. Its e...

    Authors: Christian Hartmann, Ysabel Alessa Schwietzer, Daniel Kummer, Nils Kirschnick, Esther Hoppe, Eva-Maria Thüring, Mark Glaesner-Ebnet, Frauke Brinkmann, Volker Gerke, Stefan Reuter, Masanori Nakayama and Klaus Ebnet

    Citation: BMC Molecular and Cell Biology 2020 21:30

    Content type: Research article

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  24. Low concentrations of tumor necrosis factor-alpha (TNF-α) and its receptor TNFR2 are both reported to promote osteogenic differentiation of osteoblast precursor cells. Moreover, low concentrations of TNF-α up-...

    Authors: Yu Zhang, Chengzhe Yang, Shaohua Ge, Limei Wang, Jin Zhang and Pishan Yang

    Citation: BMC Molecular and Cell Biology 2020 21:29

    Content type: Research article

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  25. The details of the folding mechanisms have not yet been fully understood for many proteins, and it is believed that the information on the folding mechanism of a protein is encoded in its amino acid sequence. ...

    Authors: Risako Kimura, Panyavut Aumpuchin, Shoya Hamaue, Takumi Shimomura and Takeshi Kikuchi

    Citation: BMC Molecular and Cell Biology 2020 21:28

    Content type: Research article

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  27. Progesterone receptor membrane component 1 (PGRMC1) is often elevated in cancers, and exists in alternative states of phosphorylation. A motif centered on PGRMC1 Y180 was evolutionarily acquired concurrently w...

    Authors: Bashar M. Thejer, Partho P. Adhikary, Sarah L. Teakel, Johnny Fang, Paul A. Weston, Saliya Gurusinghe, Ayad G. Anwer, Martin Gosnell, Jalal A. Jazayeri, Marina Ludescher, Lesley-Ann Gray, Michael Pawlak, Robyn H. Wallace, Sameer D. Pant, Marie Wong, Tamas Fischer…

    Citation: BMC Molecular and Cell Biology 2020 21:26

    Content type: Research article

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  28. Reversible cell cycle arrest (quiescence/G0) is characteristic of adult stem cells and is actively controlled at multiple levels. Quiescent cells also extend a primary cilium, which functions as a signaling hu...

    Authors: Nisha Venugopal, Ananga Ghosh, Hardik Gala, Ajoy Aloysius, Neha Vyas and Jyotsna Dhawan

    Citation: BMC Molecular and Cell Biology 2020 21:25

    Content type: Research article

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  29. Progesterone Receptor Membrane Component 1 (PGRMC1) is expressed in many cancer cells, where it is associated with detrimental patient outcomes. It contains phosphorylated tyrosines which evolutionarily preced...

    Authors: Bashar M. Thejer, Partho P. Adhikary, Amandeep Kaur, Sarah L. Teakel, Ashleigh Van Oosterum, Ishith Seth, Marina Pajic, Katherine M. Hannan, Megan Pavy, Perlita Poh, Jalal A. Jazayeri, Thiri Zaw, Dana Pascovici, Marina Ludescher, Michael Pawlak, Juan C. Cassano…

    Citation: BMC Molecular and Cell Biology 2020 21:24

    Content type: Research article

    Published on:

  30. Intervertebral disc degeneration (IDD) is characterized by the loss of nucleus pulposus cells (NPCs) and phenotypic abnormalities. Accumulating evidence suggests that long noncoding RNAs (lncRNAs) are involved...

    Authors: Hongyu Zheng, Tingting Wang, Xiangmin Li, Wei He, Zhiqiang Gong, Zhenkai Lou, Bing Wang and Xingguo Li

    Citation: BMC Molecular and Cell Biology 2020 21:23

    Content type: Research article

    Published on:

  31. Collagen is a structural protein that provides mechanical stability and defined architectures to skin. In collagen-based skin disorders this stability is lost, either due to mutations in collagens or in the ch...

    Authors: Essak S. Khan, Shrikrishnan Sankaran, Lorena Llontop and Aránzazu del Campo

    Citation: BMC Molecular and Cell Biology 2020 21:22

    Content type: Research article

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  32. Ubiquitination and ubiquitin-like protein post-translational modifications play an enormous number of roles in cellular processes. These modifications are constituted of multistep reaction cascades. Readily im...

    Authors: Gabriel Fenteany, Paras Gaur, Gaurav Sharma, Lajos Pintér, Ernő Kiss and Lajos Haracska

    Citation: BMC Molecular and Cell Biology 2020 21:21

    Content type: Methodology article

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  33. Acute myocardial infarction (AMI) is the leading cause of death globally and has thus placed a heavy burden on healthcare. Tanshinone IIA (TSA) is a major active compound, extracted from Salvia miltiorrhiza Bu...

    Authors: Liye Chen, Lili Wei, Qiongyang Yu, Haozhe Shi and George Liu

    Citation: BMC Molecular and Cell Biology 2020 21:20

    Content type: Research article

    Published on:

  34. Transcriptional responses required to maintain cellular homeostasis or to adapt to environmental stress, is in part mediated by several nucleic-acid associated proteins. In this study, we sought to establish a...

    Authors: Nastassja L. Kriel, Tiaan Heunis, Samantha L. Sampson, Nico C. Gey van Pittius, Monique J. Williams and Robin M. Warren

    Citation: BMC Molecular and Cell Biology 2020 21:19

    Content type: Research article

    Published on:

  35. Congenital dyserythropoietic anemia type I (CDA I), is an autosomal recessive disease with macrocytic anemia in which erythroid precursors in the bone marrow exhibit pathognomonic abnormalities including spong...

    Authors: Grace Swickley, Yehoshua Bloch, Lidor Malka, Adi Meiri, Sharon Noy-Lotan, Amiel Yanai, Hannah Tamary and Benny Motro

    Citation: BMC Molecular and Cell Biology 2020 21:18

    Content type: Research article

    Published on:

  36. dADD1 and dXNP proteins are the orthologs in Drosophila melanogaster of the ADD and SNF2 domains, respectively, of the ATRX vertebrate’s chromatin remodeler, they suppress position effect variegation phenotypes a...

    Authors: Silvia Meyer-Nava, Amada Torres, Mario Zurita and Viviana Valadez-Graham

    Citation: BMC Molecular and Cell Biology 2020 21:17

    Content type: Research article

    Published on:

  37. Following publication of the original article [1], an error was reported in the tagging of Eugene H. Johnson and Remya R. Nair in the author group.

    Authors: Yasmin ElTahir, Amna Al-Araimi, Remya R. Nair, Kaija J. Autio, Hongmin Tu, Jack C. Leo, Waleed Al-Marzooqi and Eugene H. Johnson

    Citation: BMC Molecular and Cell Biology 2020 21:16

    Content type: Correction

    Published on:

    The original article was published in BMC Molecular and Cell Biology 2019 20:55

  38. Tartrate–resistant acid phosphatase (TRAP/ ACP5) belongs to the binuclear metallophosphatase family and is present in two isoforms. The primary translation product is an uncleaved TRAP 5a isoform with low phos...

    Authors: Anja Reithmeier, Maria Norgård, Barbro Ek-Rylander, Tuomas Näreoja and Göran Andersson

    Citation: BMC Molecular and Cell Biology 2020 21:15

    Content type: Research article

    Published on:

  39. Fibronectin (FN) assembly into an insoluble fibrillar matrix is a crucial step in many cell responses to extracellular matrix (ECM) properties, especially with regards to the integrin-related mechanosensitive ...

    Authors: David Gagné, Yannick D. Benoit, Jean-François Groulx, Pierre H. Vachon and Jean-François Beaulieu

    Citation: BMC Molecular and Cell Biology 2020 21:14

    Content type: Research article

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  40. Alzheimer’s disease is the most common neurodegenerative disease in the elderly. Amyloid-β protein (Aβ) is the major component of neuritic plaques which are the hallmark of AD pathology. β-site APP cleaving en...

    Authors: Kaixin Qiu, Wenping Liang, Shuai Wang, Tingting Kong, Xin Wang, Chunyan Li, Zhe Wang and Yili Wu

    Citation: BMC Molecular and Cell Biology 2020 21:13

    Content type: Research article

    Published on:

  41. Gap junction protein alpha 3 (GJA3), an important pathogenic gene of congenital cataracts, encodes the transmembrane protein connexin46, which functions as an intercellular channel for voltage and chemical gating...

    Authors: Mingzhou Zhang, Chen Huang, Zhenyu Wang, Huibin Lv and Xuemin Li

    Citation: BMC Molecular and Cell Biology 2020 21:12

    Content type: Research article

    Published on:

  42. Following publication of the original article [1], the authors reported an error that occurred during the production process.

    Authors: Xiaoyan Guo, Dianke Chen, Qingxian Cai, Zhanlian Huang, Wenxiong Xu, Liang Peng and Ping Chen

    Citation: BMC Molecular and Cell Biology 2020 21:10

    Content type: Correction

    Published on:

    The original article was published in BMC Molecular and Cell Biology 2020 21:6

  43. Gene transfer by electroporation is an established method for the non-viral mediated transfection of mammalian cells. Primary cells pose a particular challenge for electroporation-mediated gene transfer, since...

    Authors: Iqbal Hyder, Shahin Eghbalsaied and Wilfried A. Kues

    Citation: BMC Molecular and Cell Biology 2020 21:9

    Content type: Methodology article

    Published on:

  44. TgDCX is a doublecortin-domain protein associated with the conoid fibers, a set of strongly curved non-tubular tubulin-polymers in Toxoplasma. TgDCX deletion impairs conoid structure and parasite invasion. TgDCX ...

    Authors: Jacqueline M. Leung, Eiji Nagayasu, Yu-Chen Hwang, Jun Liu, Phillip G. Pierce, Isabelle Q. Phan, Robin A. Prentice, John M. Murray and Ke Hu

    Citation: BMC Molecular and Cell Biology 2020 21:8

    Content type: Research article

    Published on:

  45. Interferon-alpha (IFNα) is a first-line treatment option for chronic hepatitis B virus (HBV) infection, but the severe systemic side-effects limited its clinical application. Interferon-lambda (IFNλ) with comp...

    Authors: Xiaoyan Guo, Dianke Chen, Qingxian Cai, Zhanlian Huang, Wenxiong Xu, Liang Peng and Ping Chen

    Citation: BMC Molecular and Cell Biology 2020 21:6

    Content type: Research article

    Published on:

  46. The tumor suppressor p53 is a major regulator of the DNA damage response and has been suggested to selectively bind and activate cell-type specific gene expression programs. However recent studies and meta-ana...

    Authors: Antonina Hafner, Lyubov Kublo, Michael Tsabar, Galit Lahav and Jacob Stewart-Ornstein

    Citation: BMC Molecular and Cell Biology 2020 21:5

    Content type: Research article

    Published on:

  47. PM2.5 is associated closely with an increased risk of membranous nephropathy (MN), however, whether PM2.5 could induce podocytes injury, the underlying pathology for MN, has not be thoroughly studied. Triptoli...

    Authors: Qiang Wan, Zhongyong Liu, Ming Yang, Peng Deng, Nana Tang and Yanwei Liu

    Citation: BMC Molecular and Cell Biology 2020 21:4

    Content type: Research article

    Published on:

  48. ZNF143 is an important transcriptional regulator protein conserved in metazoans and estimated to bind over 2000 promoter regions of both messenger RNA and small nuclear RNA genes. The use of zebrafish is a use...

    Authors: Laura Huning and Gary R. Kunkel

    Citation: BMC Molecular and Cell Biology 2020 21:3

    Content type: Research article

    Published on:

  49. Monoclonal antibodies (mAbs) and their derivatives have become one of the most important classes of therapeutic drugs. Their multiple applications increased the interest for understanding their complex structu...

    Authors: Mercè Farràs, Ramón Román, Marc Camps, Joan Miret, Óscar Martínez, Xavier Pujol, Antoni Casablancas and Jordi Joan Cairó

    Citation: BMC Molecular and Cell Biology 2020 21:2

    Content type: Research article

    Published on:

  50. In the bovine placenta, intimate fetomaternal contacts are restricted to discrete placentomes. Here, widely branched fetal chorionic villi interdigitate with corresponding maternal caruncular crypts. The fetal...

    Authors: Marina Polei, Juliane Günther, Dirk Koczan and Rainer Fürbass

    Citation: BMC Molecular and Cell Biology 2020 21:1

    Content type: Research article

    Published on:

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    3.485 - 2-year Impact Factor
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