Articles
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Citation: BMC Molecular and Cell Biology 2022 23:6
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A potential implication of UDP-glucuronosyltransferase 2B10 in the detoxification of drugs used in pediatric hematopoietic stem cell transplantation setting: an in silico investigation
Sinusoidal occlusion syndrome (SOS) is a potentially severe complication following hematopoietic stem cell transplantation (HSCT) in pediatric patients. Treatment related risk factors such as intensity of cond...
Citation: BMC Molecular and Cell Biology 2022 23:5 -
An integrative analysis of DNA methylation and transcriptome showed the dysfunction of MAPK pathway was involved in the damage of human chondrocyte induced by T-2 toxin
T-2 toxin is thought to induce the growth plate and articular cartilage damage of Kashin-Beck disease (KBD), an endemic osteochondropathy in China. This study aims to explore the potential underlying mechanism...
Citation: BMC Molecular and Cell Biology 2022 23:4 -
Influence of mechanical and TGF-β3 stimulation on the tenogenic differentiation of tonsil-derived mesenchymal stem cells
Organogenesis from tonsil-derived mesenchymal cells (TMSCs) has been reported, wherein tenogenic markers are expressed depending on the chemical stimulation during tenogenesis. However, there are insufficient ...
Citation: BMC Molecular and Cell Biology 2022 23:3 -
Mutational landscape and in silico structure models of SARS-CoV-2 spike receptor binding domain reveal key molecular determinants for virus-host interaction
SARS-CoV-2, the causative agent of COVID-19 pandemic is a RNA virus prone to mutations. Formation of a stable binding interface between the Receptor Binding Domain (RBD) of SARS-CoV-2 Spike (S) protein and Ang...
Citation: BMC Molecular and Cell Biology 2022 23:2 -
Compression enhances invasive phenotype and matrix degradation of breast cancer cells via Piezo1 activation
Uncontrolled growth in solid breast cancer generates mechanical compression that may drive the cancer cells into a more invasive phenotype, but little is known about how such compression affects the key events...
Citation: BMC Molecular and Cell Biology 2022 23:1 -
Molecular characterization of equine thymidine kinase 1 and preliminary evaluation of its suitability as a serum biomarker for equine lymphoma
Thymidine kinase 1 (TK1) plays a key role in the synthesis of deoxythymidine triphosphate (dTTP) and is thus important for DNA replication and cell proliferation. The expression of TK1 is highest during S-phas...
Citation: BMC Molecular and Cell Biology 2021 22:59 -
Fyn kinase regulates dopaminergic neuronal apoptosis in animal and cell models of high glucose (HG) treatment
High glucose (HG) is linked to dopaminergic neuron loss and related Parkinson’s disease (PD), but the mechanism is unclear.
Citation: BMC Molecular and Cell Biology 2021 22:58 -
Spinoculation and retronectin highly enhance the gene transduction efficiency of Mucin-1-specific chimeric antigen receptor (CAR) in human primary T cells
Producing an appropriate number of engineered cells is considered as one of the influential factors in the successful treatments with chimeric antigen receptor (CAR) T cells. To this aim, the transduction rate...
Citation: BMC Molecular and Cell Biology 2021 22:57 -
Long non-coding RNA TUG1 promotes proliferation and migration in PDGF-BB-stimulated HASMCs by regulating miR-216a-3p/SMURF2 axis
Abnormal proliferation and migration of human airway smooth muscle cells (HASMCs) play an important role in the development of childhood asthma. Long non-coding RNAs (lncRNAs) have been demonstrated to partici...
Citation: BMC Molecular and Cell Biology 2021 22:56 -
Extracellular matrix alterations in the skin of patients affected by psoriasis
Psoriasis is a chronic inflammatory disease dependent upon a complex interaction between genetic predisposition and immunological factors. It is characterized by skin lesions throughout the body, causing great...
Citation: BMC Molecular and Cell Biology 2021 22:55 -
KDM6A mutations promote acute cytoplasmic DNA release, DNA damage response and mitosis defects
KDM6A, encoding a histone demethylase, is one of the top ten mutated epigenetic cancer genes. The effect of mutations on its structure and function are however poorly characterized.
Citation: BMC Molecular and Cell Biology 2021 22:54 -
Protein kinase C regulates organic anion transporter 1 through phosphorylating ubiquitin ligase Nedd4–2
Organic anion transporter 1 (OAT1) is a drug transporter expressed on the basolateral membrane of the proximal tubule cells in kidneys. It plays an essential role in the disposition of numerous clinical therap...
Citation: BMC Molecular and Cell Biology 2021 22:53 -
A computational model of mutual antagonism in the mechano-signaling network of RhoA and nitric oxide
RhoA is a master regulator of cytoskeletal contractility, while nitric oxide (NO) is a master regulator of relaxation, e.g., vasodilation. There are multiple forms of cross-talk between the RhoA/ROCK pathway a...
Citation: BMC Molecular and Cell Biology 2021 22(Suppl 1):47 -
Intercellular transfer of mitochondrial DNA carrying metastasis-enhancing pathogenic mutations from high- to low-metastatic tumor cells and stromal cells via extracellular vesicles
Mitochondrial DNA (mtDNA) carrying certain pathogenic mutations or single nucleotide variants (SNVs) enhances the invasion and metastasis of tumor cells, and some of these mutations are homoplasmic in tumor ce...
Citation: BMC Molecular and Cell Biology 2021 22:52 -
Comparative transcriptomic analysis reveals gene regulation mediated by caspase activity in a chordate organism
Apoptosis is a caspase regulated cell death present in all metazoans defined by a conserved set of morphological features. A well-described function of apoptosis is the removal of excessive cells during develo...
Citation: BMC Molecular and Cell Biology 2021 22:51 -
Normal seminal plasma could preserve human spermatozoa against cryopreservation damages in Oligozoospermic patients
Cryopreservation of human spermatozoa has been identified as an efficient procedure to preserve fertility in men before any cancer therapy or surgical infertility treatment. Despite the benefits of the procedu...
Citation: BMC Molecular and Cell Biology 2021 22:50 -
Evaluation of selected carotenoids of Lycopersicon esculentum variants as therapeutic targets for ‘Alzheimer’s disease: an in silico approach
The seriousness and menace of the worldwide weight of ‘Alzheimer’s disease have been related to a few factors, which incorporate antioxidant system depletion, mutation of proteins, and high expression of choli...
Citation: BMC Molecular and Cell Biology 2021 22:49 -
Intracellular targeting of Cisd2/Miner1 to the endoplasmic reticulum
Cisd1 and Cisd2 proteins share very similar structures with an N-terminal membrane-anchoring domain and a C-terminal cytosolic domain containing an iron-cluster binding domain and ending with a C-terminal KKxx...
Citation: BMC Molecular and Cell Biology 2021 22:48 -
MDMX is essential for the regulation of p53 protein levels in the absence of a functional MDM2 C-terminal tail
MDM2 is an E3 ubiquitin ligase that is able to ubiquitinate p53, targeting it for proteasomal degradation. Its homologue MDMX does not have innate E3 activity, but is able to dimerize with MDM2. Although mouse...
Citation: BMC Molecular and Cell Biology 2021 22:46 -
The 3D nuclear conformation of the major histocompatibility complex changes upon cell activation both in porcine and human macrophages
The crucial role of the major histocompatibility complex (MHC) for the immune response to infectious diseases is well-known, but no information is available on the 3D nuclear organization of this gene-dense re...
Citation: BMC Molecular and Cell Biology 2021 22:45 -
Systematic identification of non-canonical transcription factor motifs
Sequence-specific transcription factors (TFs) recognize motifs of related nucleotide sequences at their DNA binding sites. Upon binding at these sites, TFs regulate critical molecular processes such as gene ex...
Citation: BMC Molecular and Cell Biology 2021 22:44 -
An alternative D. melanogaster 7SK snRNP
The 7SK small nuclear RNA (snRNA) found in most metazoans is a key regulator of P-TEFb which in turn regulates RNA polymerase II elongation. Although its primary sequence varies in protostomes, its secondary s...
Citation: BMC Molecular and Cell Biology 2021 22:43 -
Effect of bacterial infection on sperm quality and DNA fragmentation in subfertile men with Leukocytospermia
Although bacterial infections have been recognized as a possible cause of male infertility, the effect of bacterial infections on sperm quality and sperm DNA fragmentation remains controversial. The current st...
Citation: BMC Molecular and Cell Biology 2021 22:42 -
SH3BGRL3 binds to myosin 1c in a calcium dependent manner and modulates migration in the MDA-MB-231 cell line
The human SH3 domain Binding Glutamic acid Rich Like 3 (SH3BGRL3) gene is highly conserved in phylogeny and widely expressed in human tissues. However, its function is largely undetermined. The protein was found ...
Citation: BMC Molecular and Cell Biology 2021 22:41 -
Construction and characterization of EGFP reporter plasmid harboring putative human RAX promoter for in vitro monitoring of retinal progenitor cells identity
In retinal degenerative disease, progressive and debilitating conditions result in deterioration of retinal cells and visual loss. In human, retina lacks the inherent capacity for regeneration. Therefore, rege...
Citation: BMC Molecular and Cell Biology 2021 22:40 -
Cell-in-cell phenomenon: leukocyte engulfment by non-tumorigenic cells and cancer cell lines
Research on cell-in-cell (CIC) phenomena, including entosis, emperipolesis and cannibalism, and their biological implications has increased in recent years. Homotypic and heterotypic engulfment of various targ...
Citation: BMC Molecular and Cell Biology 2021 22:39 -
Disruption of Drosophila larval muscle structure and function by UNC45 knockdown
Proper muscle function is heavily dependent on highly ordered protein complexes. UNC45 is a USC (named since this region is shared by three proteins UNC45/CRO1/She4P) chaperone that is necessary for myosin inc...
Citation: BMC Molecular and Cell Biology 2021 22:38 -
Chick fetal organ spheroids as a model to study development and disease
Organ culture models have been used over the past few decades to study development and disease. The in vitro three-dimensional (3D) culture system of organoids is well known, however, these 3D systems are both...
Citation: BMC Molecular and Cell Biology 2021 22:37 -
Effects of temperature on proliferation of myoblasts from donor piglets with different thermoregulatory maturities
Climate change and the associated risk for the occurrence of extreme temperature events or permanent changes in ambient temperature are important in the husbandry of farm animals. The aim of our study was to i...
Citation: BMC Molecular and Cell Biology 2021 22:36 -
Complex II subunit SDHD is critical for cell growth and metabolism, which can be partially restored with a synthetic ubiquinone analog
Succinate dehydrogenase (Complex II) plays a dual role in respiration by catalyzing the oxidation of succinate to fumarate in the mitochondrial Krebs cycle and transferring electrons from succinate to ubiquino...
Citation: BMC Molecular and Cell Biology 2021 22:35 -
Genotype-determined EGFR-RTK heterodimerization and its effects on drug resistance in lung Cancer treatment revealed by molecular dynamics simulations
Epidermal growth factor receptor (EGFR) and its signaling pathways play a vital role in pathogenesis of lung cancer. By disturbing EGFR signaling, mutations of EGFR may lead to progression of cancer or the eme...
Citation: BMC Molecular and Cell Biology 2021 22:34 -
Effect of Voacamine upon inhibition of hypoxia induced fatty acid synthesis in a rat model of methyln-nitrosourea induced mammary gland carcinoma
In the present study, fatty acid synthesis is targeted to combat mammary gland carcinoma by activating prolyl hydroxylase-2 with Voacamine alone and in combination with Tamoxifen. It was hypothesized that the ...
Citation: BMC Molecular and Cell Biology 2021 22:33 -
Methodology for comprehensive cell-level analysis of wound healing experiments using deep learning in MATLAB
Endothelial healing after deployment of cardiovascular devices is particularly important in the context of clinical outcome. It is therefore of great interest to develop tools for a precise prediction of endot...
Citation: BMC Molecular and Cell Biology 2021 22:32 -
Retraction Note: Evaluation of PAX8 expression promotes the proliferation of stomach Cancer cells
Citation: BMC Molecular and Cell Biology 2021 22:31 -
sFLT01 modulates invasion and metastasis in prostate cancer DU145 cells by inhibition of VEGF/GRP78/MMP2&9 axis
About 90% of cancer-related deaths are due to metastasis of cancer cells, and angiogenesis is a critical step in this process. sFLT01 is a novel fusion protein and a dual-targeting agent that neutralizes both ...
Citation: BMC Molecular and Cell Biology 2021 22:30 -
Impact of uORFs in mediating regulation of translation in stress conditions
A large fraction of genes contains upstream ORFs (uORFs) in the 5′ untranslated region (5’UTR). The translation of uORFs can inhibit the translation of the main coding sequence, for example by causing prematur...
Citation: BMC Molecular and Cell Biology 2021 22:29 -
Novel leukocyte-depleted platelet-rich plasma-based skin equivalent as an in vitro model of chronic wounds: a preliminary study
Chronic leg ulcerations are associated with Haemoglobin disorders, Type2 Diabetes Mellitus, and long-term venous insufficiency, where poor perfusion and altered metabolism develop into a chronic inflammation t...
Citation: BMC Molecular and Cell Biology 2021 22:28 -
Assessing nucleic acid binding activity of four dinoflagellate cold shock domain proteins from Symbiodinium kawagutii and Lingulodinium polyedra
Dinoflagellates have a generally large number of genes but only a small percentage of these are annotated as transcription factors. Cold shock domain (CSD) containing proteins (CSPs) account for roughly 60% of...
Citation: BMC Molecular and Cell Biology 2021 22:27 -
The Glypican proteoglycans show intrinsic interactions with Wnt-3a in human prostate cancer cells that are not always associated with cascade activation
Prostate cancer occurs through multiple steps until advanced metastasis. Signaling pathways studies can result in the identification of targets to interrupt cancer progression. Glypicans are cell surface prote...
Citation: BMC Molecular and Cell Biology 2021 22:26 -
SEM and TEM for identification of capsular fibrosis and cellular behavior around breast implants – a descriptive analysis
Capsular fibrosis (CF) is the most common long-term complication in implant-based breast augmentation. It is well accepted that the foreign body response (FBR) instigates the development of fibrotic disease. O...
Citation: BMC Molecular and Cell Biology 2021 22:25 -
Uncarboxylated osteocalcin alleviates the inhibitory effect of high glucose on osteogenic differentiation of mouse bone marrow–derived mesenchymal stem cells by regulating TP63
Progressive population aging has contributed to the increased global prevalence of diabetes and osteoporosis. Inhibition of osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) by hyperglyc...
Citation: BMC Molecular and Cell Biology 2021 22:24 -
Online biophysical predictions for SARS-CoV-2 proteins
The SARS-CoV-2 virus, the causative agent of COVID-19, consists of an assembly of proteins that determine its infectious and immunological behavior, as well as its response to therapeutics. Major structural bi...
Citation: BMC Molecular and Cell Biology 2021 22:23 -
Association of Sonic Hedgehog with the extracellular matrix requires its zinc-coordination center
Sonic Hedgehog (Shh) has a catalytic cleft characteristic for zinc metallopeptidases and has significant sequence similarities with some bacterial peptidoglycan metallopeptidases defining a subgroup within the...
Citation: BMC Molecular and Cell Biology 2021 22:22 -
Cyr61 promotes Schwann cell proliferation and migration via αvβ3 integrin
Schwann cells (SCs) play a crucial role in the repair of peripheral nerves. This is due to their ability to proliferate, migrate, and provide trophic support to axon regrowth. During peripheral nerve injury, S...
Citation: BMC Molecular and Cell Biology 2021 22:21 -
A cell-based ribozyme reporter system employing a chromosomally-integrated 5′ exonuclease gene
Bioinformatic genome surveys indicate that self-cleaving ribonucleic acids (ribozymes) appear to be widespread among all domains of life, although the functions of only a small number have been validated by bi...
Citation: BMC Molecular and Cell Biology 2021 22:20 -
Responsiveness of human bronchial fibroblasts and epithelial cells from asthmatic and non-asthmatic donors to the transforming growth factor-β1 in epithelial-mesenchymal trophic unit model
The asthma-related airway wall remodeling is associated i.a. with a damage of bronchial epithelium and subepithelial fibrosis. Functional interactions between human bronchial epithelial cells and human bronchi...
Citation: BMC Molecular and Cell Biology 2021 22:19 -
Intracellular pH regulation: characterization and functional investigation of H+ transporters in Stylophora pistillata
Reef-building corals regularly experience changes in intra- and extracellular H+ concentrations ([H+]) due to physiological and environmental processes. Stringent control of [H+] is required to maintain the homeo...
Citation: BMC Molecular and Cell Biology 2021 22:18 -
SPRD: a surface plasmon resonance database of common factors for better experimental planning
Surface plasmon resonance is a label-free biophysical technique that is widely used in investigating biomolecular interactions, including protein-protein, protein-DNA, and protein-small molecule binding. Surfa...
Citation: BMC Molecular and Cell Biology 2021 22:17 -
STAU2 protein level is controlled by caspases and the CHK1 pathway and regulates cell cycle progression in the non-transformed hTERT-RPE1 cells
Staufen2 (STAU2) is an RNA binding protein involved in the posttranscriptional regulation of gene expression. In neurons, STAU2 is required to maintain the balance between differentiation and proliferation of ...
Citation: BMC Molecular and Cell Biology 2021 22:16
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