Figure 3

The distribution of C-moesin-GFP parallels dynamic changes in the actin cytoskeleton. In (A), a live, fluorescent cell was imaged for 16 minutes. Note retraction of a lamellipodium (top arrow) and advance of another (lower arrow), as the cell changes direction and begins to migrate towards the bottom of the page. The retracting lamellipodium from (A) is shown at higher magnification and temporal resolution in (B). The fifty second sequence starts after the first panel of (A) and ends before the second panel. Note kinking, buckling and withdrawal of a rib-like microfilament bundle within the lamella. See also three related movies