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  1. The cranial region is a complex set of blood vessels, cartilage, nerves and soft tissues. The reconstruction of cranial defects caused by trauma, congenital defects and surgical procedures presents clinical ch...

    Authors: Yang Liu, Pingping Niu, Mengqi Zhou and Hui Xue
    Citation: BMC Molecular and Cell Biology 2022 23:43
  2. COVID-19 is a disease caused by SARS-CoV-2, which can cause mild to serious infections in humans. We aimed to explore the effect of growth hormone (GH)/estrogen/androgen in normal human lung epithelial BEAS-2B...

    Authors: Zemin Zhu, Zhijian Zhao, Xun Chen, Zhou Chu, Yi He, Yingzheng Tan, Juan Zhou and Caixi Tang
    Citation: BMC Molecular and Cell Biology 2022 23:42
  3. Despite the recent progress in the differentiation strategies of stem cells into pancreatic beta cell lineage, current protocols are not optimized for different cell types. The purpose of this study is to inve...

    Authors: Riham M. Aly, Hadeer A. Aglan, Ghada Nour Eldeen and Hanaa H. Ahmed
    Citation: BMC Molecular and Cell Biology 2022 23:41
  4. Aquaporins are channel proteins, form pores in the membrane of biological cells to facilitate the transcellular and transepithelial water movement. The role of Aquaporins in carcinogenesis has become an area o...

    Authors: Amir Hossein Mansourabadi, Azin Aghamajidi, Fatemeh Faraji, Shirin Taghizadeh, Leila Mohamed Khosroshahi, Mona Bahramkiya and Maryam Azimi
    Citation: BMC Molecular and Cell Biology 2022 23:40
  5. The AAA + ATPase p97 is an essential unfoldase/segragase involved in a multitude of cellular processes. It functions as a molecular machine critical for protein homeostasis, homotypic membrane fusion events an...

    Authors: Abolfazl Mirzadeh, George Kobakhidze, Rémi Vuillemot, Slavica Jonic and Isabelle Rouiller
    Citation: BMC Molecular and Cell Biology 2022 23:39
  6. Glioblastoma (GBM) represents nearly one-half of primary brain tumors, and the median survival of patients with GBM is only 14.6 months. Surgery followed by radiation with concomitant temozolomide (TMZ) therap...

    Authors: Hao Chen, Chunlin Li, Haiyang Hu and Bin Zhang
    Citation: BMC Molecular and Cell Biology 2022 23:38
  7. Endometriosis is one of the most common gynecological diseases, and seriously reduces the quality of life of patients. However, the pathogenesis of this disease is unclear. Therefore, more studies are needed t...

    Authors: Yanan He, J. Wang, Xinyan Jiang, Jianhua Gao, Yan Cheng, Tian Liang, Jun Zhou, Liyuan Sun and Guangmei Zhang
    Citation: BMC Molecular and Cell Biology 2022 23:37
  8. The non-catalytic region of tyrosine kinase (Nck) is an adaptor protein, which is ubiquitously expressed in many types of cells. In T cells, the Nck1 isoform promotes T cell receptor signalling as well as acti...

    Authors: Aussanee Nuiyen, Araya Rattanasri, Piyamaporn Wipa, Sittiruk Roytrakul, Apirath Wangteeraprasert, Sutatip Pongcharoen and Jutaporn Ngoenkam
    Citation: BMC Molecular and Cell Biology 2022 23:36
  9. In the past decade, we have seen the emergence of sequence-based methods to understand chromosome organization. With the confluence of in situ approaches to capture information on looping, topological domains, an...

    Authors: Meng Wang, Benjamin D. Sunkel, William C. Ray and Benjamin Z. Stanton
    Citation: BMC Molecular and Cell Biology 2022 23:35
  10. Dysregulation of ACTA2-AS1 and miR-532-5p and their functions in various cancers have been widely reported. Their potential of serving as biomarkers in triple-negative breast cancer (TNBC) remains unknown. Thi...

    Authors: Yi Peng, Xiaoxi Huang and Hongmei Wang
    Citation: BMC Molecular and Cell Biology 2022 23:34
  11. Intrinsically disordered proteins (IDPs) lack a stable three-dimensional structure under physiological conditions but play crucial roles in many biological processes. Intrinsically disordered proteins perform ...

    Authors: CanZhuang Sun, YongE Feng and GuoLiang Fan
    Citation: BMC Molecular and Cell Biology 2022 23:33
  12. The single-cell platform provided revolutionary way to study cellular biology. Technologically, a sophistic protocol of isolating qualified single cells would be key to deliver to single-cell platform, which r...

    Authors: Manman Gao, Peng Guo, Xizhe Liu, Penghui Zhang, Zhongyuan He, Liru Wen, Shaoyu Liu, Zhiyu Zhou and Weimin Zhu
    Citation: BMC Molecular and Cell Biology 2022 23:32
  13. Many attempts are used to discover mechanisms driving impaired angiogenesis in age-related diseases. Angiogenesis is highly regulated by different signaling pathways. Here, we investigated the angiogenesis pot...

    Authors: Nesa Janamo Berenjabad, Vahid Nejati and Jafar Rezaie
    Citation: BMC Molecular and Cell Biology 2022 23:31
  14. Lubricin, a proteoglycan encoded by the PRG4 gene, is synthesised by superficial zone (SFZ) chondrocytes and synovial cells. It reduces friction between joints and allows smooth sliding of tendons. Although lubri...

    Authors: Takashi Satake, Shingo Komura, Hitomi Aoki, Akihiro Hirakawa, Yuuki Imai and Haruhiko Akiyama
    Citation: BMC Molecular and Cell Biology 2022 23:30
  15. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters the host cell by binding to angiotensin-converting enzyme 2 (ACE2) receptors. ACE2 is expressed on human airway epithelial cells. Increased A...

    Authors: Yoshitaka Wakabayashi, Shin Nakayama, Ai Yamamoto and Takatoshi Kitazawa
    Citation: BMC Molecular and Cell Biology 2022 23:29
  16. In several human cancers, Krüppel-like factor 5 (KLF5), a zinc finger transcription factor, can contribute to both tumor progression or suppression; however, the precise role of KLF5 in nasopharyngeal carcinom...

    Authors: Chien-Han Yuan, Wei-Chi Hsu, A.-Mei Huang, Ben-Chih Yuan, I.-Hung Chen, Chia-An Hsu, Rong-Feng Chen, Yih-Min Chu, Hui-Hui Lin and Hung-Lung Ke
    Citation: BMC Molecular and Cell Biology 2022 23:28
  17. Synechocystis histidine kinase, Sll0474: Hik28, a signal protein in a two-component signal transduction system, plays a critical role in responding to a decrease in growth temperature and is also involved in nit...

    Authors: Pavinee Kurdrid, Rayakorn Yutthanasirikul, Sirilak Saree, Jittisak Senachak, Monpaveekorn Saelee and Apiradee Hongsthong
    Citation: BMC Molecular and Cell Biology 2022 23:27
  18. Tunneling nanotubes (TNTs) are special membrane structures for intercellular communications. Vital cargoes (such as mitochondria) could be delivered from healthy cells to rescue damaged ones through TNTs. The ...

    Authors: Chia-Wei Lee, Chia-Chen Kuo, Chi-Jung Liang, Huei-Jyuan Pan, Chia-Ning Shen and Chau-Hwang Lee
    Citation: BMC Molecular and Cell Biology 2022 23:26
  19. Chaperonin containing TCP1 subunit 3 (CCT3) acts as an oncogene in cancers, whereas its role and underlying mechanisms in lung adenocarcinoma (LUAD) are poorly understood. This study investigated the clinical ...

    Authors: Kun Wang, Jian He, Changling Tu, Hui Xu, Xugang Zhang, Yongchang Lv and Chao Song
    Citation: BMC Molecular and Cell Biology 2022 23:25
  20. Poor decidualization and abnormal autophagy conditions in the endometria of adenomyosis patients have been reported previously. However, the specific regulatory mechanism of decidualization in adenomyosis and ...

    Authors: Jie Mei, Xiaoqiang Sheng, Yuan Yan, Xinyu Cai, Chunxue Zhang, Jiao Tian, Mei Zhang, Jidong Zhou, Huizhi Shan and Chenyang Huang
    Citation: BMC Molecular and Cell Biology 2022 23:24
  21. Signal transducer and activator of transcription 3 (STAT3) is an oncogenic transcription factor that promotes cell proliferation and immunomodulation in untransformed cells and maintains stemness of transforme...

    Authors: Lena Sophie Behrendsen, Priyanka Rajeev Menon, Muhammad Jawad Khan, Anke Gregus, Oliver Wirths, Thomas Meyer and Julia Staab
    Citation: BMC Molecular and Cell Biology 2022 23:23
  22. Augmentation of oxidative stress after estrogen deficiency leading to functional deficiency of jawbone bone marrow mesenchymal stem cells (BMSCs) causes jawbone loss in osteoporosis. OSGIN2, an oxidative stres...

    Authors: Yi Shuai, Bingyao Liu, Liang Rong, Bingyi Shao, Bo Chen and Lei Jin
    Citation: BMC Molecular and Cell Biology 2022 23:22
  23. Hepatocellular carcinoma (HCC) is a common malignancy. Long non-coding RNAs (lncRNAs) partake in the progression of HCC. However, the role of lncRNA MAPKAPK5-AS1 in the development of HCC has not been fully cl...

    Authors: Zongqing Peng, Xinhua Ouyang, Yexing Wang and Qiming Fan
    Citation: BMC Molecular and Cell Biology 2022 23:21
  24. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/1471-2091-13-25.

    Authors: Yuejin Li, Na Liu, Damao Huang, Zhenlin Zhang, Zhengke Peng, Chaojun Duan, Xiaowei Tang, Gongjun Tan, Guangrong Yan, Wenhua Mei and Faqing Tang
    Citation: BMC Molecular and Cell Biology 2022 23:20
  25. Triple-negative breast cancer (TNBC) is the most severe type of breast cancer owing to its high heterogeneity, aggressiveness and lack of treatment. Studies have reported that uncarboxylated osteocalcin (GluOC...

    Authors: Jiaojiao Xu, Luyao Ma, Danqing Wang and Jianhong Yang
    Citation: BMC Molecular and Cell Biology 2022 23:18
  26. We have previously found that, in the pathogenic yeast Candida albicans, 18S and 25S ribosomal RNA components, containing more than one phosphate on their 5′-end were resistant to 5′-monophosphate requiring 5′ → ...

    Authors: Miguel A. Rocha, Bhavani S. Gowda and Jacob Fleischmann
    Citation: BMC Molecular and Cell Biology 2022 23:17
  27. Besides controlling the expression of peripheral tissue antigens, the autoimmune regulator (AIRE) gene also regulates the expression of adhesion genes in medullary thymic epithelial cells (mTECs), an essential pr...

    Authors: Ana Carolina Monteleone-Cassiano, Janaina A. Dernowsek, Romario S. Mascarenhas, Amanda Freire Assis, Dimitrius Pitol, Natalia Chermont Santos Moreira, Elza Tiemi Sakamoto-Hojo, João Paulo Mardegan Issa, Eduardo A. Donadi and Geraldo Aleixo Passos
    Citation: BMC Molecular and Cell Biology 2022 23:15
  28. The nucleolus is a subnuclear, non-membrane bound domain that is the hub of ribosome biogenesis and a critical regulator of cell homeostasis. Rapid growth and division of cells in tumors are correlated with in...

    Authors: Marzia Tagliaferro, Paolo Rosa, Gian Carlo Bellenchi, Daniela Bastianelli, Rosa Trotta, Claudia Tito, Francesco Fazi, Antonella Calogero and Donatella Ponti
    Citation: BMC Molecular and Cell Biology 2022 23:13
  29. The epidermal growth factor receptor (EGFR) is involved in various developmental processes, and alterations of its extracellular segment are associated with several types of cancers, in particular glioblastoma...

    Authors: Matthieu R. Zeronian, Sofia Doulkeridou, Paul M. P. van Bergen en Henegouwen and Bert J. C. Janssen
    Citation: BMC Molecular and Cell Biology 2022 23:12
  30. To circumvent some pitfalls related to acute status, chronic model of asthma is conceived to be more suitable approach to guarantee the conditions which are similar to human pulmonary disease. Here, possible t...

    Authors: Sajjad Taghizadeh, Rana Keyhanmanesh, Reza Rahbarghazi, Jafar Rezaie, Aref Delkhosh, Mehdi Hassanpour, Hossein Heiran, Arshad Ghaffari-Nasab and Mahdi Ahmadi
    Citation: BMC Molecular and Cell Biology 2022 23:11
  31. Swi6 acts as a transcription factor in budding yeast, functioning in two different heterodimeric complexes, SBF and MBF, that activate the expression of distinct but overlapping sets of genes. Swi6 undergoes r...

    Authors: Kenneth D. Belanger, William T. Yewdell, Matthew F. Barber, Amy N. Russo, Mark A. Pettit, Emily K. Damuth, Naveen Hussain, Susan J. Geier and Karyn G. Belanger
    Citation: BMC Molecular and Cell Biology 2022 23:10
  32. Image segmentation is considered an important step in image processing. Fuzzy c-means clustering is one of the common methods of image segmentation. However, this method suffers from drawbacks, such as sensiti...

    Authors: Maryam Mohammdian-khoshnoud, Ali Reza Soltanian, Arash Dehghan and Maryam Farhadian
    Citation: BMC Molecular and Cell Biology 2022 23:9
  33. Protein-protein interactions form the basis of every organism and thus, investigating their dynamics, intracellular protein localization, trafficking and interactions of distinct proteins such as receptors and...

    Authors: Victoria Elisabeth Groß, Miron Mikhailowitsch Gershkovich, Torsten Schöneberg, Anette Kaiser and Simone Prömel
    Citation: BMC Molecular and Cell Biology 2022 23:8
  34. Authors: Shannon Robin, Khalil Ben Hassine, Jayaraman Muthukumaran, Simona Jurkovic Mlakar, Maja Krajinovic, Tiago Nava, Chakradhara Rao S. Uppugunduri and Marc Ansari
    Citation: BMC Molecular and Cell Biology 2022 23:6

    The original article was published in BMC Molecular and Cell Biology 2022 23:5

  35. Sinusoidal occlusion syndrome (SOS) is a potentially severe complication following hematopoietic stem cell transplantation (HSCT) in pediatric patients. Treatment related risk factors such as intensity of cond...

    Authors: Shannon Robin, Khalil Ben Hassine, Jayaraman Muthukumaran, Simona Jurkovic Mlakar, Maja Krajinovic, Tiago Nava, Chakradhara Rao S. Uppugunduri and Marc Ansari
    Citation: BMC Molecular and Cell Biology 2022 23:5

    The Correction to this article has been published in BMC Molecular and Cell Biology 2022 23:6

  36. T-2 toxin is thought to induce the growth plate and articular cartilage damage of Kashin-Beck disease (KBD), an endemic osteochondropathy in China. This study aims to explore the potential underlying mechanism...

    Authors: Xuena Yang, Xue Xiao, Lu Zhang, Bo Wang, Ping Li, Bolun Cheng, Chujun Liang, Mei Ma, Xiong Guo, Feng Zhang and Yan Wen
    Citation: BMC Molecular and Cell Biology 2022 23:4
  37. Organogenesis from tonsil-derived mesenchymal cells (TMSCs) has been reported, wherein tenogenic markers are expressed depending on the chemical stimulation during tenogenesis. However, there are insufficient ...

    Authors: Jaeyeon Wee, Hyang Kim, Sang-Jin Shin, Taeyong Lee and Seung Yeol Lee
    Citation: BMC Molecular and Cell Biology 2022 23:3

    The Correction to this article has been published in BMC Molecular and Cell Biology 2022 23:7

  38. SARS-CoV-2, the causative agent of COVID-19 pandemic is a RNA virus prone to mutations. Formation of a stable binding interface between the Receptor Binding Domain (RBD) of SARS-CoV-2 Spike (S) protein and Ang...

    Authors: Shijulal Nelson-Sathi, P. K. Umasankar, E. Sreekumar, R. Radhakrishnan Nair, Iype Joseph, Sai Ravi Chandra Nori, Jamiema Sara Philip, Roshny Prasad, K. V. Navyasree, Shikha Ramesh, Heera Pillai, Sanu Ghosh, T. R. Santosh Kumar and M. Radhakrishna Pillai
    Citation: BMC Molecular and Cell Biology 2022 23:2
  39. Uncontrolled growth in solid breast cancer generates mechanical compression that may drive the cancer cells into a more invasive phenotype, but little is known about how such compression affects the key events...

    Authors: Mingzhi Luo, Grace Cai, Kenneth K. Y. Ho, Kang Wen, Zhaowen Tong, Linhong Deng and Allen P. Liu
    Citation: BMC Molecular and Cell Biology 2022 23:1
  40. Thymidine kinase 1 (TK1) plays a key role in the synthesis of deoxythymidine triphosphate (dTTP) and is thus important for DNA replication and cell proliferation. The expression of TK1 is highest during S-phas...

    Authors: Liya Wang, Lucia Unger, Hanan Sharif, Staffan Eriksson, Vinzenz Gerber and Henrik Rönnberg
    Citation: BMC Molecular and Cell Biology 2021 22:59
  41. Producing an appropriate number of engineered cells is considered as one of the influential factors in the successful treatments with chimeric antigen receptor (CAR) T cells. To this aim, the transduction rate...

    Authors: Alireza Rajabzadeh, Amir Ali Hamidieh and Fatemeh Rahbarizadeh
    Citation: BMC Molecular and Cell Biology 2021 22:57
  42. Abnormal proliferation and migration of human airway smooth muscle cells (HASMCs) play an important role in the development of childhood asthma. Long non-coding RNAs (lncRNAs) have been demonstrated to partici...

    Authors: Xinfang Wang and Junsong Chen
    Citation: BMC Molecular and Cell Biology 2021 22:56
  43. Psoriasis is a chronic inflammatory disease dependent upon a complex interaction between genetic predisposition and immunological factors. It is characterized by skin lesions throughout the body, causing great...

    Authors: Mariana Fatima Muaccad Gama Wagner, Thérèse Rachell Theodoro, Carlos D’. Apparecida Santos Machado Filho, Luiza Keiko Matsuka Oyafuso and Maria Aparecida Silva Pinhal
    Citation: BMC Molecular and Cell Biology 2021 22:55
  44. Organic anion transporter 1 (OAT1) is a drug transporter expressed on the basolateral membrane of the proximal tubule cells in kidneys. It plays an essential role in the disposition of numerous clinical therap...

    Authors: Zhou Yu, Chenchang Liu, Jinghui Zhang, Zhengxuan Liang and Guofeng You
    Citation: BMC Molecular and Cell Biology 2021 22:53

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