Articles
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Citation: BMC Molecular and Cell Biology 2024 25:17
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Upregulated dual oxidase 1-induced oxidative stress and caspase-1-dependent pyroptosis reflect the etiologies of heart failure
Oxidative stress is implicated in the pathogenesis of heart failure. Dual oxidase 1 (DUOX1) might be important in heart failure development through its mediating role in oxidative stress. This study was design...
Citation: BMC Molecular and Cell Biology 2024 25:16 -
Comparing chemical transfection, electroporation, and lentiviral vector transduction to achieve optimal transfection conditions in the Vero cell line
Transfection is an important analytical method for studying gene expression in the cellular environment. There are some barriers to efficient DNA transfection in host cells, including circumventing the plasma ...
Citation: BMC Molecular and Cell Biology 2024 25:15 -
High-fat diet enhances cell proliferation and compromises intestinal permeability in a translational canine intestinal organoid model
Emerging evidence underscores the responsiveness of the mammalian intestine to dietary cues, notably through the involvement of LGR5 + intestinal stem cells in orchestrating responses to diet-driven signals. H...
Citation: BMC Molecular and Cell Biology 2024 25:14 -
mTOR signaling pathway regulation HIF-1 α effects on LPS induced intestinal mucosal epithelial model damage
Sepsis-induced small-intestinal injury is associated with increased morbidity and mortality. Our previous study and other papers have shown that HIF-1α has a protective effect on intestinal mucosal injury in s...
Citation: BMC Molecular and Cell Biology 2024 25:13 -
Long non-coding RNA SOX2OT in tamoxifen-resistant breast cancer
Hormone receptor (HR)-positive breast cancer can become aggressive after developing hormone-treatment resistance. This study elucidated the role of long non-coding RNA (lncRNA) SOX2OT in tamoxifen-resistant (T...
Citation: BMC Molecular and Cell Biology 2024 25:12 -
Mice lacking DIO3 exhibit sex-specific alterations in circadian patterns of corticosterone and gene expression in metabolic tissues
Disruption of circadian rhythms is associated with neurological, endocrine and metabolic pathologies. We have recently shown that mice lacking functional type 3 deiodinase (DIO3), the enzyme that clears thyroi...
Citation: BMC Molecular and Cell Biology 2024 25:11 -
Optimization of seeding density of OP9 cells to improve hematopoietic differentiation efficiency
OP9 mouse stromal cell line has been widely used to induce differentiation of human embryonic stem cells (hESCs) into hematopoietic stem/progenitor cells (HSPCs). However, the whole co-culture procedure usuall...
Citation: BMC Molecular and Cell Biology 2024 25:10 -
Development of an in vitro human alveolar epithelial air-liquid interface model using a small molecule inhibitor cocktail
The alveolar epithelium is exposed to numerous stimuli, such as chemicals, viruses, and bacteria that cause a variety of pulmonary diseases through inhalation. Alveolar epithelial cells (AECs) cultured in vitr...
Citation: BMC Molecular and Cell Biology 2024 25:9 -
Mechanical stretch leads to increased caveolin-1 content and mineralization potential in extracellular vesicles from vascular smooth muscle cells
Hypertension-induced mechanical stress on vascular smooth muscle cells (VSMCs) is a known risk factor for vascular remodeling, including vascular calcification. Caveolin-1 (Cav-1), an integral structural compo...
Citation: BMC Molecular and Cell Biology 2024 25:8 -
Melatonin reduces lung injury in type 1 diabetic mice by the modulation of autophagy
In recent years, the role of autophagy has been highlighted in the pathogenesis of diabetes and inflammatory lung diseases. In this study, using a diabetic model of mice, we investigated the expression of auto...
Citation: BMC Molecular and Cell Biology 2024 25:7 -
TonEBP/NFAT5 expression is associated with cisplatin resistance and migration in macrophage-induced A549 cells
Macrophages promote angiogenesis, metastasis, and drug resistance in several cancers. Similarly, TonEBP/NFAT5 induces metastasis in renal carcinoma and colon cancer cells. However, the role of this transcripti...
Citation: BMC Molecular and Cell Biology 2024 25:6 -
Optimizing combination therapy in prostate cancer: mechanistic insights into the synergistic effects of Paclitaxel and Sulforaphane-induced apoptosis
Combination therapies in cancer treatment have demonstrated synergistic or additive outcomes while also reducing the development of drug resistance compared to monotherapy. This study explores the potential of...
Citation: BMC Molecular and Cell Biology 2024 25:5 -
CTC together with Shh and Nrf2 are prospective diagnostic markers for HNSCC
The lack of appropriate prognostic biomarkers remains a significant obstacle in the early detection of Head and Neck Squamous Cell Carcinoma (HNSCC), a cancer type with a high mortality rate. Despite considera...
Citation: BMC Molecular and Cell Biology 2024 25:4 -
Prioritization of Trypanosoma brucei editosome protein interactions interfaces at residue resolution through proteome-scale network analysis
Trypanosoma brucei is the causative agent for trypanosomiasis in humans and livestock, which presents a growing challenge due to drug resistance. While identifying novel drug targets is vital, the process is dela...
Citation: BMC Molecular and Cell Biology 2024 25:3 -
Sumoylation of SAP130 regulates its interaction with FAF1 as well as its protein stability and transcriptional repressor function
Fas-associated factor 1 (FAF1) is a multidomain protein that interacts with diverse partners to affect numerous cellular processes. Previously, we discovered two Small Ubiquitin-like Modifier (SUMO)-interactin...
Citation: BMC Molecular and Cell Biology 2024 25:2 -
Loss of Dec1 inhibits alcohol-induced hepatic lipid accumulation and circadian rhythm disorder
Chronic alcohol exposure increases liver damage such as lipid accumulation and hepatitis, resulting in hepatic cirrhosis. Chronic alcohol intake is known to disturb circadian rhythms in humans and animals. DEC...
Citation: BMC Molecular and Cell Biology 2024 25:1 -
Association between plasma L-carnitine levels and mitochondrial DNA copy number
Mitochondria are key cytoplasmic organelles in eukaryotic cells that generate adenosine triphosphate (ATP) through the electron transport chain and oxidative phosphorylation. Mitochondrial DNA (mtDNA) copy num...
Citation: BMC Molecular and Cell Biology 2023 24:35 -
Effect of Emi1 gene silencing on the proliferation and invasion of human breast cancer cells
Breast cancer is the most common malignant tumour in women. The early silk-splitting inhibitor protein 1 Emi1 is responsible for mediating ubiquitin protein degradation. The present study investigated the effe...
Citation: BMC Molecular and Cell Biology 2023 24:34 -
TNFα induces Caspase-3 activity in hematopoietic progenitor cells CD34+, CD33+, and CD41 + of myelodysplastic syndromes
Cytopenia is the primary feature of Myelodysplastic Syndrome, even in the presence of hypercellular bone marrow. TNFα is recognized as both a proinflammatory, and proapoptotic cytokine with a well established ...
Citation: BMC Molecular and Cell Biology 2023 24:33 -
From network analysis to experimental validation: identification of regulators of non-muscle myosin II contractility using the folded-gastrulation signaling pathway
The morphogenetic process of apical constriction, which relies on non-muscle myosin II (NMII) generated constriction of apical domains of epithelial cells, is key to the development of complex cellular pattern...
Citation: BMC Molecular and Cell Biology 2023 24:32 -
Simple, low-cost, and well-performing method, the outgrowth technique, for the isolation of cells from nasal polyps
Epithelial cells are an important part of the pathomechanism in chronic rhinosinusitis with nasal polyps. It is therefore essential to establish a robust method for the isolation and culture of epithelial cell...
Citation: BMC Molecular and Cell Biology 2023 24:31 -
Comprehensive brain tissue metabolomics and biological network technology to decipher the mechanism of hydrogen-rich water on Radiation-induced cognitive impairment in rats
Hydrogen-rich water (HRW) has been shown to prevent cognitive impairment caused by ionizing radiation. This study aimed to investigate the pharmacological effects and mechanisms of HRW on ionizing radiation by...
Citation: BMC Molecular and Cell Biology 2023 24:30 -
Mineral elements and adiposity-related consequences in adolescents with intellectual disabilities
Patients with intellectual disabilities are shown to have a limited capacity for cooperation, communication,and other biological consequences, which significantly require a specialized interest in healthcare p...
Citation: BMC Molecular and Cell Biology 2023 24:29 -
Glycyrrhizin inhibits LPS-induced inflammatory responses in goat ruminal epithelial cells in vitro
Inflammation plays a crucial role in the progression of Subacute Ruminal Acidosis (SARA). The experiment was designed to investigate anti-inflammatory effects of glycyrrhizin on goats ruminal epithelial cells ...
Citation: BMC Molecular and Cell Biology 2023 24:28 -
D-galactose-induced mitochondrial oxidative damage and apoptosis in the cochlear stria vascularis of mice
Age-related hearing loss, known as presbycusis, is the result of auditory system degeneration. Numerous studies have suggested that reactive oxygen species (ROS) and mitochondrial oxidative damage play importa...
Citation: BMC Molecular and Cell Biology 2023 24:27 -
Keratin 19 binds and regulates cytoplasmic HNRNPK mRNA targets in triple-negative breast cancer
Heterogeneous nuclear ribonucleoprotein K (HNRNPK) regulates pre-mRNA processing and long non-coding RNA localization in the nucleus. It was previously shown that shuttling of HNRNPK to the cytoplasm promotes ...
Citation: BMC Molecular and Cell Biology 2023 24:26 -
A computational peptide model induces cancer cells’ apoptosis by docking Kringle 5 to GRP78
Cells can die through a process called apoptosis in both pathological and healthy conditions. Cancer development and progression may result from abnormal apoptosis. The 78-kDa glucose-regulated protein (GRP78)...
Citation: BMC Molecular and Cell Biology 2023 24:25 -
BMP9 maintains the phenotype of HTR-8/Svneo trophoblast cells by activating the SDF1/CXCR4 pathway
Bone morphogenetic protein 9 (BMP9) has been shown to regulate processes such as angiogenesis, endothelial dysfunction, and tumorigenesis. However, the role of BMP9 in preeclampsia (PE) is unclear. The purpose...
Citation: BMC Molecular and Cell Biology 2023 24:24 -
Emodin and aloe-emodin, two potential molecules in regulating cell migration of skin cells through the MAP kinase pathway and affecting Caenorhabditis elegans thermotolerance
Emodin and aloe-emodin are two anthraquinones having positive effects in wound healing. However, their mechanism of action of wound healing is not fully understood. The MAP kinase family, which plays an active...
Citation: BMC Molecular and Cell Biology 2023 24:23 -
Knockdown of ELF4 aggravates renal injury in ischemia/reperfusion mice through promotion of pyroptosis, inflammation, oxidative stress, and endoplasmic reticulum stress
Renal ischemia/reperfusion (I/R) injury is a major cause of acute kidney injury (AKI). Dysfunction of E74-like ETS transcription factor 4 (ELF4) leads to inflammation. This research intended to look into the f...
Citation: BMC Molecular and Cell Biology 2023 24:22 -
Janus Kinase 3 phosphorylation and the JAK/STAT pathway are positively modulated by follicle-stimulating hormone (FSH) in bovine granulosa cells
Janus kinase 3 (JAK3) is a member of the JAK family of tyrosine kinase proteins involved in cytokine receptor-mediated intracellular signal transduction through the JAK/STAT signaling pathway. JAK3 was previou...
Citation: BMC Molecular and Cell Biology 2023 24:21 -
Genetic and protein interaction studies between the ciliary dyslexia candidate genes DYX1C1 and DCDC2
DYX1C1 (DNAAF4) and DCDC2 are two of the most replicated dyslexia candidate genes in genetic studies. They both have demonstrated roles in neuronal migration, in cilia growth and function and they both are cytosk...
Citation: BMC Molecular and Cell Biology 2023 24:20 -
SUMOylation of PDGF receptor α affects signaling via PLCγ and STAT3, and cell proliferation
The platelet-derived growth factor (PDGF) family of ligands exerts their cellular effects by binding to α- and β-tyrosine kinase receptors (PDGFRα and PDGFRβ, respectively). SUMOylation is an important posttra...
Citation: BMC Molecular and Cell Biology 2023 24:19 -
Myogenic differentiation of human myoblasts and Mesenchymal stromal cells under GDF11 on Poly-É›-caprolactone-collagen I-Polyethylene-nanofibers
For the purpose of skeletal muscle engineering, primary myoblasts (Mb) and adipogenic mesenchymal stem cells (ADSC) can be co-cultured and myogenically differentiated. Electrospun composite nanofiber scaffolds...
Citation: BMC Molecular and Cell Biology 2023 24:18 -
Computational analysis of missense variant CYP4F2*3 (V433M) in association with human CYP4F2 dysfunction: a functional and structural impact
Cytochrome P450 4F2 (CYP4F2) enzyme is a member of the CYP4 family responsible for the metabolism of fatty acids, therapeutic drugs, and signaling molecules such as arachidonic acid, tocopherols, and vitamin K...
Citation: BMC Molecular and Cell Biology 2023 24:17 -
Using RNA-seq to identify suitable housekeeping genes for hypoxia studies in human adipose-derived stem cells
Hypoxic culture conditions have been used to study the impact of oxygen deprivation has on gene expression in a number of disease models. However, hypoxia response elements present in the promoter regions of s...
Citation: BMC Molecular and Cell Biology 2023 24:16 -
SCAT8/miR-125b-5p axis triggers malignant progression of nasopharyngeal carcinoma through SCARB1
Nasopharyngeal carcinoma is a tumor with high malignancy and poor prognosis, which severely affects the health of the patients. LncRNAs and microRNAs are crucial for the occurrence and development of nasophary...
Citation: BMC Molecular and Cell Biology 2023 24:15 -
ARNTL2 upregulation of ACOT7 promotes NSCLC cell proliferation through inhibition of apoptosis and ferroptosis
Recent studies have reported that the circadian transcription factor aryl hydrocarbon receptor nuclear translocator like 2 (ARNTL2) promotes the metastatic progression of lung adenocarcinoma. However, the mole...
Citation: BMC Molecular and Cell Biology 2023 24:14 -
Evolutionary relevance of single nucleotide variants within the forebrain exclusive human accelerated enhancer regions
Human accelerated regions (HARs) are short conserved genomic sequences that have acquired significantly more nucleotide substitutions than expected in the human lineage after divergence from chimpanzees. The f...
Citation: BMC Molecular and Cell Biology 2023 24:13 -
The DNA demethylation-regulated SFRP2 dictates the progression of endometriosis via activation of the Wnt/β-catenin signaling pathway
Endometriosis cause decreases in life quality and pelvic pain in reproductive-age women. Methylation abnormalities played a functional role in the progression of endometriosis, this study aimed to explore the ...
Citation: BMC Molecular and Cell Biology 2023 24:12 -
Pre-treatment with IL-6 potentiates β-cell death induced by pro-inflammatory cytokines
Type I Diabetes mellitus (T1D) is characterized by a specific destruction of β-cells by the immune system. During this process pro-inflammatory cytokines are released in the pancreatic islets and contribute for β...
Citation: BMC Molecular and Cell Biology 2023 24:11 -
Role of the human solute carrier family 14 member 1 gene in hypoxia-induced renal cell carcinoma occurrence and its enlightenment to cancer nursing
Hypoxia is considered a critical contributor to renal cell carcinoma progression, including invasion and metastasis. However, the potential mechanisms by which it promotes invasion and metastasis have not yet ...
Citation: BMC Molecular and Cell Biology 2023 24:10 -
Cyclic tensile force modifies calvarial osteoblast function via the interplay between ERK1/2 and STAT3
Mechanical therapies, such as distraction osteogenesis, are widely used in dental clinics. During this process, the mechanisms by which tensile force triggers bone formation remain of interest. Herein, we inve...
Citation: BMC Molecular and Cell Biology 2023 24:9 -
Urine-derived mesenchymal stem cells-derived exosomes enhances survival and proliferation of aging retinal ganglion cells
This study was designed to investigate to test the effect of exosomes from urine-derived mesenchymal stem cells (USCs) on the survival and viability of aging retinal ganglion cells (RGCs), and explored the pre...
Citation: BMC Molecular and Cell Biology 2023 24:8 -
RPL11 promotes non-small cell lung cancer cell proliferation by regulating endoplasmic reticulum stress and cell autophagy
Abnormal biogenesis and ribosome free function of ribosomal proteins (RPs) is important for tumorgenesis and development. Ribosomal protein L11 (RPL11) is a component of ribosomal 60 S large subunit with diffe...
Citation: BMC Molecular and Cell Biology 2023 24:7 -
Sperm capacitation and transcripts levels are altered by in vitro THC exposure
Delta-9-tetrahydrocannabinol (THC) is the primary phytocannabinoid responsible for the psychoactive properties of cannabis and is known to interact with the endocannabinoid system, which is functionally presen...
Citation: BMC Molecular and Cell Biology 2023 24:6 -
The dual role of Nrf2 in melanoma: a systematic review
Melanoma is the most lethal type of skin cancer that originates from the malignant transformation of melanocytes. Although novel treatments have improved patient survival in melanoma, the overall prognosis rem...
Citation: BMC Molecular and Cell Biology 2023 24:5 -
Hyperoxia exposure upregulates Dvl-1 and activates Wnt/β-catenin signaling pathway in newborn rat lung
Bronchopulmonary dysplasia is a serious and lifelong pulmonary disease in premature neonates that influences around one-quarter of premature newborns. The wingless-related integration site /β-catenin signaling...
Citation: BMC Molecular and Cell Biology 2023 24:4 -
Circ-ATL1 silencing reverses the activation effects of SIRT5 on smooth muscle cellular proliferation, migration and contractility in intracranial aneurysm by adsorbing miR-455
Alterations in vascular smooth muscle cells (VSMCs) contribute to the pathogenesis of intracranial aneurysms (IAs). However, molecular mechanisms underlying these changes remain unknown. The present study aime...
Citation: BMC Molecular and Cell Biology 2023 24:3
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