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Table 1 Accumulated insulin, C-peptide and pro-insulin release and insulin content.

From: Generation and characterization of human insulin-releasing cell lines

  VGA APM CPR hBeta-cells
Insulin release (ng/ngDNA) 5 × 10-2 ± 1 × 10-2 2.5 × 10-2 ± 3 × 10-3 9 × 10-3 ± 1 × 10-3 9 × 10-5 ± 1 × 10-5
Insulin content (ng/ng DNA) <3 × 10-7 <3 × 10-7 <3 × 10-7 3 × 10-4 ± 1 × 10-4
Pro-Insulin release (pmol/ng DNA) 8 × 10-4 ± 2 × 10-4 3 × 10-4 ± 3 × 10-5 3 × 10-4 ± 1 × 10-5 N.D.
C-peptide release (ng/ng DNA) 5 × 10-2 ± 1 × 10-2 5 × 10-2 ± 1 × 10-2 5 × 10-2 ± 1 × 10-2 5 × 10-2 ± 1 × 10-2
Glucose-induced insulin secretion (Stimulation Index)a 1 1 1 >3
  1. a Stimulation Index = Insulin secretion (20 mM glucose): Insulin release (2.8 mM glucose)
  2. N.D.: not detected