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Figure 3 | BMC Cell Biology

Figure 3

From: Mactinin, a fragment of cytoskeletal α-actinin, is a novel inducer of heat shock protein (Hsp)-90 mediated monocyte activation

Figure 3

Mactinin-induced monocyte migration is blocked by Hsp90 Inhibitors. Monocytes were incubated with medium alone or with one of 3 Hsp90 inhibitors (G: geldanamycin; A: 17-AAG; D: 17-DMAG), prior to testing for mactinin-induced or fmpl-induced (control) chemotaxis. In the absence of mactinin or fmlp, 1302 +/- 122 cells migrated (not shown). Mactinin-induced migration was significantly inhibited by each of the Hsp90 inhibitors, whereas fmlp-induced migration was not. Data is shown as the mean +/- SEM. N = 3. Significance of differences in migration in the presence vs absence of Hsp90 inhibitors: *P < 0.01.

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BMC Molecular and Cell Biology

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