Figure 1From: Disruption of occludin function in polarized epithelial cells activates the extrinsic pathway of apoptosis leading to cell extrusion without loss of transepithelial resistanceOccludin and occludin disrupting molecules. The general topology of the tetraspanin molecule occludin and the FLAG tagged truncated fragment used to make the truncated molecule, F-ΔOcc, are shown in diagrammatic format along with the location of an occludin disrupting peptide. COOH, C-terminus; PM, plasma membrane; F, FLAG epitope tag; rs, restriction site used to make truncated occludin; LYHY, conserved peptide sequence used in later experiments.Back to article page