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Figure 1 | BMC Cell Biology

Figure 1

From: Disruption of occludin function in polarized epithelial cells activates the extrinsic pathway of apoptosis leading to cell extrusion without loss of transepithelial resistance

Figure 1

Occludin and occludin disrupting molecules. The general topology of the tetraspanin molecule occludin and the FLAG tagged truncated fragment used to make the truncated molecule, F-ΔOcc, are shown in diagrammatic format along with the location of an occludin disrupting peptide. COOH, C-terminus; PM, plasma membrane; F, FLAG epitope tag; rs, restriction site used to make truncated occludin; LYHY, conserved peptide sequence used in later experiments.

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