Figure 6

Proposed Model by which Crosstalks Between ITGA5 and IGF2/IGFBP2 Signalling Trigger Osteogenic Differentiation in Human MSCs. ITGA5 expression induced by dexamethasone or ITGA5 activation by agonists upregulate signalling pathways that activate IGF2/IGFBP2 expression in hMSCs which in turn triggers osteoblast differentiation, revealing that ITGA5 and IGF2/IGFBP2 crosstalks are important mechanisms controlling osteogenic differentiation in human bone marrow derived mesenchymal stromal cells.