Figure 4From: Digging deeper into lymphatic vessel formation in vitro and in vivoVacuolization and lumen formation during lymphangiogenesis in vivo. Lymphangiogenesis was observed after thermal cauterization of the cornea (A, B) and in lymphangioma (C, D). (A): Prominent pinocytic activity (arrowhead) is visible along the plasma membrane and at cell junction. (B) Endothelial cells (en) containing intracellular vesicles are aligned and surrounded by matrix-free extracellular spaces (*). (C): Aligned elongated endothelial cells surrounded by extracellular spaces. Note the coalescence of intracellular vesicles (cv) and the presence of a blood vessel (bv) containing a white cell. (D) Vesicle coalescence (cv) into an intracellular luminal space is visible through a process similar to that depicted in B. bv = blood vessel; cv = coalescent vesicle; en: endothelial cell. Scale bars: 1 μm.Back to article page