Impaired tube formation of MSC from DM bone marrow was restored by oxytocin. (A) MSCs were pretreated with PBS, oxytocin, curcumin, carvedilol, or rosuvastatin prior to tube formation assay. (B) Representative images from the in vitro angiogenesis assay showed the retarded tube formation in DM-MSC. Both tube length and tube area were measured and expressed in graphs (n=5). (C) Representative images of tube formation of DM-MSC after treatment with PBS or 100 nM of oxytocin for 24 hours were presented (n=4). * p < 0.01 vs. Non-DM-MSC.