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Table 1 Summary of cytotoxicity data of transport substrates and inhibitors (24 hours of exposure)

From: Primary porcine proximal tubular cells as an alternative to human primary renal cells in vitro: an initial characterization

Substances (Abbrev.)

Solvent

Concentration range tested (n concentrations)

Significant effects

cimetidine (CIM)

H2O

1 μM-948 μM (7)

no

estrone sulfate (ES)

MeOH

1 μM-1 mM (7)

no

p-aminohippuric acid (PAH)

H2O

1 μM-1 mM (7)

no

methotrexate (MTX)

50% EtOH

1 μM-500 μM (6)

no

probenecid (PROB)

50% EtOH

1 μM-1 mM (7)

no

folic acid (FA)

0.1 M bicarbonate

1 μM-560 μM (6)

no

bromosulphophthalein (BSP)

H2O

1 μM-500 μM (6)

no

ochratoxin A (OTA)

EtOH

1 μM-1 mM (7)

no

ochratoxins B (OTB)

EtOH

1 μM-500 μM (6)

no

  1. Data represent n = 3-4 independent experiments, conducted in duplicate. One-way ANOVA with Dunnett’s multiple comparison test (P < 0.05).