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Table 1 Summary of cytotoxicity data of transport substrates and inhibitors (24 hours of exposure)

From: Primary porcine proximal tubular cells as an alternative to human primary renal cells in vitro: an initial characterization

Substances (Abbrev.) Solvent Concentration range tested (n concentrations) Significant effects
cimetidine (CIM) H2O 1 μM-948 μM (7) no
estrone sulfate (ES) MeOH 1 μM-1 mM (7) no
p-aminohippuric acid (PAH) H2O 1 μM-1 mM (7) no
methotrexate (MTX) 50% EtOH 1 μM-500 μM (6) no
probenecid (PROB) 50% EtOH 1 μM-1 mM (7) no
folic acid (FA) 0.1 M bicarbonate 1 μM-560 μM (6) no
bromosulphophthalein (BSP) H2O 1 μM-500 μM (6) no
ochratoxin A (OTA) EtOH 1 μM-1 mM (7) no
ochratoxins B (OTB) EtOH 1 μM-500 μM (6) no
  1. Data represent n = 3-4 independent experiments, conducted in duplicate. One-way ANOVA with Dunnett’s multiple comparison test (P < 0.05).