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Table 2 Summary of changes in several important parameters involved in high glucose induced protein aggregation in ZDF brain and the effect of NaHS on them

From: Increased protein aggregation in Zucker Diabetic Fatty rat brain: identification of key mechanistic targets and the therapeutic application of hydrogen sulfide

Parameters analyzed ZDF brain NaHS + ZDF brain
ROS levels
Protein aggregates
Protein synthesis (mTOR, S6)
FABP
Thiols
CBS
CML expression
UB-proteins
Autophagy ↓ (LC3-II↓, LC3-I↑) ↑ (LC3-II↓, LC3-I↓)
Tau and p-tau
Fibronectin
  1. ZDF brain was compared to lean brain as control and NaHS treated ZDF brain was compared to ZDF brain as control. The arrows indicate the changes in each parameter.