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Table 2 Summary of changes in several important parameters involved in high glucose induced protein aggregation in ZDF brain and the effect of NaHS on them

From: Increased protein aggregation in Zucker Diabetic Fatty rat brain: identification of key mechanistic targets and the therapeutic application of hydrogen sulfide

Parameters analyzed

ZDF brain

NaHS + ZDF brain

ROS levels

Protein aggregates

Protein synthesis (mTOR, S6)

FABP

Thiols

CBS

CML expression

UB-proteins

Autophagy

↓ (LC3-II↓, LC3-I↑)

↑ (LC3-II↓, LC3-I↓)

Tau and p-tau

Fibronectin

  1. ZDF brain was compared to lean brain as control and NaHS treated ZDF brain was compared to ZDF brain as control. The arrows indicate the changes in each parameter.