SCE Assay on cell lines with and without inducer.
A. Histogram of the distribution of SCEs from induced cell lines. The number of SCEs per 46 chromosomes is plotted vs. the number of cells or metaphases. B. Graphical representation of the relative correction for each GFP-BLM allele (Table 2 &3). C. Metaphase chromosome spread from an induced cell transfected with GFP-ΔC1 BLM. A large ring chromosome is shown at the top of the spread. The SCEs are visualized with acridine orange staining.