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Table 1 Comparison of the mean lethal dose D37(or LC37), i. e., the radiation dose (or NCS concentration) leaving 1/e = 37% survival, among the two cell lines investigated.

From: Poly(ADP-ribose) polymerase (PARP-1) is not involved in DNA double-strand break recovery

  PARP-1+/+ 3T3 PARP-1-/- 3T3
D37γ-Rays (Gy) 4.96 2.26
LC37 NCS (Gy.eq) 2.21 3.00
  1. The D37 (or LC37) values were calculated from the dose-dependent (γ-rays) or concentration-dependent survival curves (NCS), taking into account the mean incidence of NCS-induced DSB relative to γ-rays (1 nM NCS = 1.21 Gy.eq).