Figure 2

Conserved hydrophobic residues between human FIH-1 and Hydra -PSR Ribbon diagram of the conserved core domain (amino acids W179 to K298) of the human FIH-1 structure (structure from [15] using RIBBON (Carson 1997). The active site residues H199, D201 and H272 in FIH are highlighted in blue. The hydrophobic residues that are conserved between Hydra-PSR and human FIH-1 are highlighted in magenta.