Table 1 Effect of PBP10 on neutrophil NADPH-oxidase activity induced by receptor agonists#.
Neutrophil NADPH-oxidase activator (Concentration) | Neutrophil receptor(s) | Inhibition of NADPH-oxidase by PBP10 (1 μM) |
|---|---|---|
WKYMVM (100 nM) | FPRL1 | + |
SAA (5 μM) | FPRL1 | + |
fMLF (100 nM) | FPR | - |
Annexin9–25 (50 μM) | FPR | - |
C5a (100 ng/ml) | C5aR | - |
IL-8 (100 ng/ml) | CXCR1, CXCR2 | - |