Localization of RanGAP on chic nuclear envelopes is irregular. chic221 eye disc clones show only minor changes in distribution of (A) Lamin (red) and (B) Nups (red). But RanGAP localization (C, D red) is strongly altered appearing more clustered and patchy (arrows) than in wild-type cells, where RanGAP forms uniform dotted rings around nuclei (arrowheads). act up loss of function does not affect RanGAP (red) in acuE 636eye disc clones (E). Mutant clones are marked by the absence of green. The borders of some clones are highlighted with dashed lines.