From: Computational modeling reveals molecular details of epidermal growth factor binding
Equilibrium constants | ||
---|---|---|
K_{1} | 13.3 (molecule/site)^{-1} | In the range to be consistent with ~18% of the monomer EGFR as dimers in the absence of EGF [9, 53–56] |
K_{2} | 4.0 × 10^{3} (molecule/site)^{-1} | Calculated based on equilibrium relations given in [14] |
K_{3} | 1.2 × 10^{6} (molecule/site)^{-1} | Calculated based on equilibrium relations given in [14] |
K_{4} | 4 × 10^{8} M^{-1} | In the range suggested by [1, 4, 58–60] |
K_{5}, K_{6} | 1.2 × 10^{11} M^{-1} | In the range suggested by [9, 53–56] |
Kinetic parameters | ||
k_{1b}, k_{2b} | 0.17 sec^{-1} | [61] |
k_{3b} | 1.7 × 10^{-3} sec^{-1} | [61] |
k_{4b}, k_{5b} | 2.9 × 10^{-3} sec^{-1} | [34] |
k_{6b} | 5.8 × 10^{-3} sec^{-1} | [34] |
Transport parameters | ||
D_{monomer} | 2 × 10^{-14}–2 × 10^{-15} m^{2}sec^{-1} | [49, 50] |