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Table 1 Kinetic (reaction events given in Fig. 2) and transport (monomer and dimer diffusion) parameters used in hybrid null-event MC model (factors of 1/2 and 1/4 discussed in the Methods section have to be considered).

From: Computational modeling reveals molecular details of epidermal growth factor binding

Equilibrium constants
K1 13.3 (molecule/site)-1 In the range to be consistent with ~18% of the monomer EGFR as dimers in the absence of EGF [9, 53–56]
K2 4.0 × 103 (molecule/site)-1 Calculated based on equilibrium relations given in [14]
K3 1.2 × 106 (molecule/site)-1 Calculated based on equilibrium relations given in [14]
K4 4 × 108 M-1 In the range suggested by [1, 4, 58–60]
K5, K6 1.2 × 1011 M-1 In the range suggested by [9, 53–56]
Kinetic parameters
k1b, k2b 0.17 sec-1 [61]
k3b 1.7 × 10-3 sec-1 [61]
k4b, k5b 2.9 × 10-3 sec-1 [34]
k6b 5.8 × 10-3 sec-1 [34]
Transport parameters
Dmonomer 2 × 10-14–2 × 10-15 m2sec-1 [49, 50]