Table 1 Kinetic (reaction events given in Fig. 2) and transport (monomer and dimer diffusion) parameters used in hybrid null-event MC model (factors of 1/2 and 1/4 discussed in the Methods section have to be considered).
From: Computational modeling reveals molecular details of epidermal growth factor binding
Equilibrium constants | ||
|---|---|---|
K1 | 13.3 (molecule/site)-1 | In the range to be consistent with ~18% of the monomer EGFR as dimers in the absence of EGF [9, 53–56] |
K2 | 4.0 × 103 (molecule/site)-1 | Calculated based on equilibrium relations given in [14] |
K3 | 1.2 × 106 (molecule/site)-1 | Calculated based on equilibrium relations given in [14] |
K4 | 4 × 108 M-1 | In the range suggested by [1, 4, 58–60] |
K5, K6 | 1.2 × 1011 M-1 | In the range suggested by [9, 53–56] |
Kinetic parameters | ||
k1b, k2b | 0.17 sec-1 | [61] |
k3b | 1.7 × 10-3 sec-1 | [61] |
k4b, k5b | 2.9 × 10-3 sec-1 | [34] |
k6b | 5.8 × 10-3 sec-1 | [34] |
Transport parameters | ||
Dmonomer | 2 × 10-14–2 × 10-15 m2sec-1 | [49, 50] |