Figure 9

Kinesin-1 is enriched at the areas of cell-cell contacts in normal human colonic mucosa. Cross-sections of normal human colonic mucosa reveal a significant pool of kinesin-1 (red color) localized at the areas of cell-cell contacts where it colocalizes with the AJC protein, JAM-A (arrows). By contrast, kinesin-2 (red) labeling demonstrates diffuse intracellular distribution of this protein without significant colocalization with JAM-A (green) at intercellular junctions. Bar, 10 μm.