Figure 6

Thalidomide induced a sharp fall in actin polymerization pattern at the cell-cell interface. ECs doublets were treated with and without thalidomide respectively, as described elsewhere. A representative image of the ECs treated with 75 μg/ml thalidomide demonstrates a drastic drop in the degree of actin polymerization at the cell-cell interface, and that the arrays of stress fibers are formed under thalidomide challenge in ECs (see boxes in the images, figure 3b).