Figure 5
From: CYR61/CCN1 and WISP3/CCN6 are chemoattractive ligands for human multipotent mesenchymal stroma cells
Integrin ανß 5 mediates MSC migration to WISP3 but not to CYR61. Integrin ανß 5 mediates MSC migration to WISP3/CCN6 but not to CYR61/CCN1-protein. Results are presented as absolute numbers of migrated cells from three independent experiments measured in quadruplicate each (mean ± SD). MSCs were partly preincubated for 1 h with 50 μg/ml ανß 3 (LM609) or ανß 5 (P1F6) antibody (Ab) as indicated. CYR61 and WISP3 were used at a concentration of 2 μg/ml each.