From: Straw blood cell count, growth, inhibition and comparison to apoptotic bodies
CACO2 | Mouse | Note | |||
---|---|---|---|---|---|
Inhibitors | μg/ml (ppm) | Tubular T. (Morphology And count) | mg/kg/day (ppm/day) | SBC (%) Reduction | Mode of action (References) |
Sphingosine-1-phosphate | 200 | no inhibition | 1 | no change | compete for ceramide mediated apoptosis [12] |
Q-VD-OPh | 200 | no inhibition | 2 | no change | compete for caspase mediated apoptosis [9, 13] |
Pyridinyl Imidazole | 10 | > 90% inhibition | 0.01 | 30 | bind to a P38 MAPK Kd = 38 nm [18] |