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Table 2 Comparison of the effect of PI 3-kinase inhibition on gene expression in U937 and T98G cells.

From: Phosphatidylinositol 3-kinase signaling in proliferating cells maintains an anti-apoptotic transcriptional program mediated by inhibition of FOXO and non-canonical activation of NFκB transcription factors

 

Fold Change

 

U937 cells

T98G cells

Up-regulated genes

BCL6

1.3

2.8

BTG1

3.4

4.1

CCNG2

6.6

3.0

DDIT3/CHOP

1.3

2.2

IRF7

7.6

4.2

KLF6/COPEB

5.7

1.5

Down-regulated genes

BAG2

3.3

4.3

BIRC3/cIAP2

1.7

8.9

CCL2

51

11

F3

1.8

4.8

IL7R

2.5

2.6

PLAU

3.4

2.1

  1. Proliferating U937 and T98G cells were treated with LY294002 for 4 hours and gene expression was quantitated by RT-PCR. Data are expressed as average fold changes from two independent experiments. Genes in bold were up- or down-regulated in both cell lines.
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BMC Molecular and Cell Biology

ISSN: 2661-8850

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