Chemokines (pg/10
6
cells/day)
|
IP-10
|
0.8 ± 0.3 a
|
nd
|
3.5 ± 0.4 a
|
MCP-1
|
727.5 ± 86.5 a
|
336.2 ± 42.2 b
|
551.5 ± 51.6 a,b
|
Pro-inflammatory cytokines (pg/10
6
cells/day)
|
IL-6
|
46.6 ± 2.8 a
|
31.2 ± 4.3 a
|
146.0 ± 31.6 b
|
IL-7
|
102.4 ± 57.8 a
|
0.13 ± 0.19 a
|
0.07 ± 0.10 a
|
IL-8
|
628.3 ± 8.0 a
|
63.7 ± 2.7 a
|
4,466.3 ± 634.6 b
|
IL-12
|
41.5 ± 7.6 a
|
1.6 ± 2.3 a
|
nd
|
Anti-inflammatory cytokines (pg/10
6
cells/day)
|
IL-1ra
|
30.00 ± 0.01 a
|
nd
|
205.3 ± 28.7 a
|
Angiogenic factors (pg/10
6
cells/day)
|
Angiogenin
|
3,054.7 ± 74.2 a
|
995.3 ± 34.9 b
|
517.9 ± 5.3 c
|
Thrombospondin-2
|
79,967.7 ± 149.8 a
|
35,564.0 ± 1,644.6 b
|
155,582.9 ± 6,467.8 c
|
PLGF
|
102.4 ± 2.1 a
|
12.5 ± 1.0 a
|
nd
|
aFGF
|
65.7 ± 12.4 a
|
6.9 ± 6.5 b
|
14.0 ± 2.6 b
|
VEGF-D
|
24.80 ± 0.01
|
nd
|
nd
|
Endostatin
|
1,322.3 ± 24.7 a
|
1,270.4 ± 21.6 a
|
2,343.3 ± 68.7 b
|
Angiopoietin-1
|
129,196.1 ± 8,604.8 b
|
12,502.3 ± 405.8 a
|
17,114.5 ± 51.9 a
|
VEGF
|
3,431.8 ± 180.9 b
|
392.4 ± 24.4 a
|
3.4 ± 0.8 a
|
Growth factors (pg/10
6
cells/day)
|
TGF-β1
|
4,051.7 ± 0.0 a
|
1,844.7 ± 205.9 b
|
1,622.6 ± 51.1 b
|
TGF-β2
|
178.1 ± 1.1 a
|
17.7 ± 3.3 b
|
13.7 ± 3.7 b
|
HGF
|
268.0 ± 8.4 a,b
|
44.8 ± 8.6 a
|
314.0 ± 86.6 b
|
G-CSF
|
nd
|
nd
|
52.6 ± 5.9
|
PDGF-AA
|
7.9 ± 1.5 a
|
2.5 ± 4.7 a
|
6.9 ± 1.7 a
|
Extracellular matrix proteins (pg/10
6
cells/day)
|
Collagen I
|
76.6 ± 6.0 a
|
313.2 ± 53.0 b
|
15.6 ± 0.8 a
|
Collagen II
|
2,210.4 ± 911.3
|
nd
|
nd
|
Collagen III
|
12,332.2 ± 0.0 a
|
17,164.5 ± 689.8 a
|
38,914.8 ± 477.9 b
|
Collagen IV
|
116.5 ± 2.0 a
|
51.9 ± 4.2 b
|
nd
|
Elastin
|
959.3 ± 236.4 a
|
300.1 ± 6.5 b
|
nd
|
Fibronectin
|
nd
|
1.4 ± 1.2
|
nd
|
Heparan sulfate
|
235.6 ± 111.0 a
|
27.5 ± 233.0 a
|
nd
|
Laminin
|
95.5 ± 14.0 a
|
42.2 ± 15.2 a
|
nd
|
Aggrecan
|
2.7 ± 0.1 a
|
0.2 ± 0.4 a
|
nd
|
Matrix metalloproteinases (pg/10
6
cells/day)
|
MMP1
|
149.6 ± 0.0 a,b
|
284.2 ± 11.0 a
|
364.0 ± 36.9 b
|
MMP3
|
1,235.1 ± 0.0 a
|
17,387.1 ± 3,213.2 b
|
684.2 ± 49.9 a
|
MMP7
|
675.6 ± 0.0 a,b
|
102.9 ± 26.7 a
|
35.5 ± 15.7 b
|
MMP8
|
527.0 ± 152.2 a
|
nd
|
10.6 ± 157.3 b
|
MMP13
|
24,201.6 ± 124.7 a
|
22.5 ± 0.0 b
|
nd
|