Table 2 Protein secretion (expressed as mean ± standard deviation) of adipose tissue- (AT-), bone marrow- (BM-) and Wharton’s Jelly-mesenchymal stromal cells (WJ-MSC) when grown in low glucose media supplemented with 10% fetal bovine serum

IP-10

0.8 ± 0.3 ^a

nd

3.5 ± 0.4 ^a

MCP-1

727.5 ± 86.5 ^a

336.2 ± 42.2 ^b

551.5 ± 51.6 ^a,b

IL-6

46.6 ± 2.8 ^a

31.2 ± 4.3 ^a

146.0 ± 31.6 ^b

IL-7

102.4 ± 57.8 ^a

0.13 ± 0.19 ^a

0.07 ± 0.10 ^a

IL-8

628.3 ± 8.0 ^a

63.7 ± 2.7 ^a

4,466.3 ± 634.6 ^b

IL-12

41.5 ± 7.6 ^a

1.6 ± 2.3 ^a

nd

IL-1ra

30.00 ± 0.01 ^a

nd

205.3 ± 28.7 ^a

Angiogenin

3,054.7 ± 74.2 ^a

995.3 ± 34.9 ^b

517.9 ± 5.3 ^c

Thrombospondin-2

79,967.7 ± 149.8 ^a

35,564.0 ± 1,644.6 ^b

155,582.9 ± 6,467.8 ^c

PLGF

102.4 ± 2.1 ^a

12.5 ± 1.0 ^a

nd

aFGF

65.7 ± 12.4 ^a

6.9 ± 6.5 ^b

14.0 ± 2.6 ^b

VEGF-D

24.80 ± 0.01

nd

nd

Endostatin

1,322.3 ± 24.7 ^a

1,270.4 ± 21.6 ^a

2,343.3 ± 68.7 ^b

Angiopoietin-1

129,196.1 ± 8,604.8 ^b

12,502.3 ± 405.8 ^a

17,114.5 ± 51.9 ^a

VEGF

3,431.8 ± 180.9 ^b

392.4 ± 24.4 ^a

3.4 ± 0.8 ^a

TGF-β1

4,051.7 ± 0.0 ^a

1,844.7 ± 205.9 ^b

1,622.6 ± 51.1 ^b

TGF-β2

178.1 ± 1.1 ^a

17.7 ± 3.3 ^b

13.7 ± 3.7 ^b

HGF

268.0 ± 8.4 ^a,b

44.8 ± 8.6 ^a

314.0 ± 86.6 ^b

G-CSF

nd

nd

52.6 ± 5.9

PDGF-AA

7.9 ± 1.5 ^a

2.5 ± 4.7 ^a

6.9 ± 1.7 ^a

Collagen I

76.6 ± 6.0 ^a

313.2 ± 53.0 ^b

15.6 ± 0.8 ^a

Collagen II

2,210.4 ± 911.3

nd

nd

Collagen III

12,332.2 ± 0.0 ^a

17,164.5 ± 689.8 ^a

38,914.8 ± 477.9 ^b

Collagen IV

116.5 ± 2.0 ^a

51.9 ± 4.2 ^b

nd

Elastin

959.3 ± 236.4 ^a

300.1 ± 6.5 ^b

nd

Fibronectin

nd

1.4 ± 1.2

nd

Heparan sulfate

235.6 ± 111.0 ^a

27.5 ± 233.0 ^a

nd

Laminin

95.5 ± 14.0 ^a

42.2 ± 15.2 ^a

nd

Aggrecan

2.7 ± 0.1 ^a

0.2 ± 0.4 ^a

nd

MMP1

149.6 ± 0.0 ^a,b

284.2 ± 11.0 ^a

364.0 ± 36.9 ^b

MMP3

1,235.1 ± 0.0 ^a

17,387.1 ± 3,213.2 ^b

684.2 ± 49.9 ^a

MMP7

675.6 ± 0.0 ^a,b

102.9 ± 26.7 ^a

35.5 ± 15.7 ^b

MMP8

527.0 ± 152.2 ^a

nd

10.6 ± 157.3 ^b

MMP13

24,201.6 ± 124.7 ^a

22.5 ± 0.0 ^b

nd