Figure 6From: Protease 3C of hepatitis A virus induces vacuolization of lysosomal/endosomal organelles and caspase-independent cell death Origin of 3Cpro-induced vacuoles. Vacuolated A549/3Cpro and Calu-1/3Cpro cells expressing fusion proteins L1-mKate2 48 h p.t. (A) and 72 h p.t. (B), Rab5-eCFP (C), Rab7-eYFP (D), DsRed-Rab9 (E), DsRed-Rab11 (F), DsRed-Rab7dn (G), DsRed-Rab5dn (H), and LC3-RFP (I) 72 h p.t. Dominant-negative mutants of GTPases are indicated by “dn”.Back to article page