Fig. 10
From: Molecular mechanisms regulating formation, trafficking and processing of annular gap junctions
Scheme depicting the molecular signals in the Cx43-C-terminal domain hypothesized to regulate gap junction assembly and internalization based on our own (orange) and colleagues’ (green) findings. Steps [1 – 5] trigger and coordinate the transition from functional (green) into non-functional, internalization-prone gap junction channels (yellow, orange) that then are primed via post-translational modifications to allow interaction with clathrin components to mediate their internalization (red). The color scheme of the channels corresponds to the schematic gap junction shown in Fig. 9b