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Table 2 Statistical amounts of hemichannels and gap junction channels in the case of 3 co-expressed connexins

From: Cardiac Cx43, Cx40 and Cx45 co-assembling: involvement of connexins epitopes in formation of hemichannels and Gap junction channels

Hemichannels Gap junction channels
Homo-oligomerization Homomeric-homomeric docking: homotypic channels
3 3
Hetero-oligomerization Homomeric-homomeric docking: heterotypic channels
2 isoforms:
 36 (see double co-expression)
3 isoforms:
 2:2:2 ratio: 12
 3:2:1 ratio: 30
 4:1:1 ratio: 15
3
  Homomeric-heteromeric docking: heterotypic channels
3 x 93 = 279
Heteromeric-heteromeric docking: homotypic channels
93 (one per composition)
Heteromeric-heteromeric docking: heterotypic channels
36x12x30x15 – (279 + 93) = 194 028
  1. These amounts consider that each association is possible, independently on the connexins composition of hemichannels made of 2 and 3 connexin, and are indicated without considering that each channel can be in 2 different orientations