Cardiac Cx43, Cx40 and Cx45 co-assembling: involvement of connexins epitopes in formation of hemichannels and Gap junction channels

Table 2 Statistical amounts of hemichannels and gap junction channels in the case of 3 co-expressed connexins

Hemichannels	Gap junction channels
Homo-oligomerization	Homomeric-homomeric docking: homotypic channels
3	3
Hetero-oligomerization	Homomeric-homomeric docking: heterotypic channels
2 isoforms: 36 (see double co-expression) 3 isoforms: 2:2:2 ratio: 12 3:2:1 ratio: 30 4:1:1 ratio: 15	3
	Homomeric-heteromeric docking: heterotypic channels
	3 x 93 = 279
	Heteromeric-heteromeric docking: homotypic channels
	93 (one per composition)
	Heteromeric-heteromeric docking: heterotypic channels
	36x12x30x15 – (279 + 93) = 194 028

These amounts consider that each association is possible, independently on the connexins composition of hemichannels made of 2 and 3 connexin, and are indicated without considering that each channel can be in 2 different orientations

ISSN: 2661-8850