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Table 4 Categories of top enriched pathways identified by Gene Set Enrichment Analysis (GSEA) of proteomic dataset

From: Molecular targets and signaling pathways regulated by nuclear translocation of syndecan-1

Functions related to syndecan-1 SIZE p-val rank
 REACTOME_COLLAGEN_FORMATION 28 ≤0.001 1
 REACTOME_NCAM1_INTERACTIONS 16 ≤0.001 2
 REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION 38 ≤0.001 3
 KEGG_ECM_RECEPTOR_INTERACTION 51 ≤0.001 4
 REACTOME_KERATAN_SULFATE_KERATIN_METABOLISM 16 0.002 10
 REACTOME_CHONDROITIN_SULFATE_DERMATAN_ SULFATE_METABOLISM 29 0.001 16
 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS 47 ≤0.001 17
 KEGG_CELL_ADHESION_MOLECULES_CAMS 47 ≤0.001  
 REACTOME_GLYCOSAMINOGLYCAN_METABOLISM 57 0.001 28
 KEGG_FOCAL_ADHESION 137 ≤0.001 34
 REACTOME_TRANSMEMBRANE_TRANSPORT_OF_SMALL_MOLECULES 154 0.001 41
 REACTOME_CELL_JUNCTION_ORGANIZATION 36 0.032 42
 REACTOME_HEPARAN_SULFATE_HEPARIN_HS_GAG_METABOLISM 27 0.045 56
TGF β SIZE p-val rank
 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING 17 0.014 26
 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS 19 0.018 27
 KEGG_TGF_BETA_SIGNALING_PATHWAY 44 0.019 45
Immune System SIZE p-val rank
 KEGG_HEMATOPOIETIC_CELL_LINEAGE 25 0.001 12
 REACTOME_INTERFERON_GAMMA_SIGNALING 32 0.001 15
 REACTOME_IMMUNOREG_INTERACTIONS_BETWEEN_A_LYMPHOID_ AND_A_NON_LYMPHOID_CELL 16 0.005 18
 BIOCARTA_IL1R_PATHWAY 24 0.001 23
 REACTOME_IL1_SIGNALING 27 0.014 33
 KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY 58 0.023 63
  1. The GSEA analysis was performed on the proteomic dataset of NLSdel versus Fls1. Most of the top enriched pathways belong to categories already associated with syndecan-1. In addition, functions related to TGF β signaling and immune regulation were significantly enriched