Fig. 5
From: Mutant TP53 G245C and R273H promote cellular malignancy in esophageal squamous cell carcinoma
TP53 and its downstream proteins’ expression levels. a The expression levels of P53 in p53-defective cell lines H1299 and HCT116 p53−/− after UV 30 J for 12 h treatment. b Mutant TP53 R273H and R273C reduced the protein levels of P21, GADD45α and cleaved PARP after UV 30 J for 12 h treatment in KYSE150 and COLO680. Western blot of TP53 downstream proteins P21, GADD45α and cleaved PARP expression levels in KYSE150 (right) COLO680 (left) cell lines after UV 30 J treatment for 12 h