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Table 2 Best-fit parameter values for our mathematical formalism

From: Effect of dose and dose rate on temporal γ-H2AX kinetics in mouse blood and spleen mononuclear cells in vivo following Cesium-137 administration

Parameter Affected process Best-fit value 95% CIs
k (MBq− 1 × days− 1) Initial increase in γ-H2AX levels when irradiation starts 4.65 × 105 3.28 × 105 6.60 × 105
α (MBq−1) Decrease in γ-H2AX levels due to death of heavily damaged cells 0.255 0.183 0.323
r (days−1) Time-dependent decrease in γ-H2AX levels due to radionuclide excretion, DNA repair, and death of heavily damaged cells 1.07 × 106 7.54 × 105 1.52 × 106
p (unitless) 0.153 0.146 0.159