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Table 2 Best-fit parameter values for our mathematical formalism

From: Effect of dose and dose rate on temporal γ-H2AX kinetics in mouse blood and spleen mononuclear cells in vivo following Cesium-137 administration

Parameter

Affected process

Best-fit value

95% CIs

k (MBq− 1 × days− 1)

Initial increase in γ-H2AX levels when irradiation starts

4.65 × 105

3.28 × 105

6.60 × 105

α (MBq−1)

Decrease in γ-H2AX levels due to death of heavily damaged cells

0.255

0.183

0.323

r (days−1)

Time-dependent decrease in γ-H2AX levels due to radionuclide excretion, DNA repair, and death of heavily damaged cells

1.07 × 106

7.54 × 105

1.52 × 106

p (unitless)

0.153

0.146

0.159