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Table 3 Paclitaxel and EMSO Combination Index (CI) against A2780 and A2780/T Cells

From: Proton pump inhibitors can reverse the YAP mediated paclitaxel resistance in epithelial ovarian cancer

Combination type Inhibitory rate CI Interaction type
A2780+ PTX(0.05) 4.7   
A2780+ EMSO(50) 1.6   
A2780+ PTX(0.05) + EMSO(50) 6.3 1.0 Additive
A2780+ PTX(0.25) 29.1   
A2780+ EMSO(100) 9.2   
A2780+ PTX(0.25) + EMSO(100) 38.3 1.0 Additive
A2780+ PTX(1.25) 72.3   
A2780+ EMSO(130) 44.2   
A2780+ PTX(1.25) + EMSO(130) 95.3 0.94 Synergistic
A2780/T+ PTX(0.04) 0.7   
A2780/T+ EMSO(50) 1.2   
A2780/T+ PTX(0.04) + EMSO(50) 2.0 1.0 Additive
A2780/T + PTX(0.90) 1.6   
A2780/T+ EMSO(100) 2.7   
A2780/T + PTX(0.90) + EMSO(100) 4.3 1.0 Additive
A2780/T + PTX(5.0) 24.3   
A2780/T+ EMSO(150) 43.9   
A2780/T + PTX(5.0) + EMSO(150) 85.4 0.91 Synergistic
  1. CI < 1, synergistic; CI =1, additive; or antagonistic,CI > 1