Table 1 Effect of high-risk nsSNPs in GJA3 gene on post translational modification sites predicted by ModPred tool
Residue | Modification | Score | Confidence | High-risk nsSNP |
|---|---|---|---|---|
G2 | N-terminal acetylation | 0.53 | Low | G2D, G2S |
Proteolytic cleavage | 0.52 | Low | ||
D3 | Proteolytic cleavage | 0.7 | Medium | D3H, D3Y |
S5 | Proteolytic cleavage | 0.59 | Low | S5R |
H17 | Proteolytic cleavage | 0.51 | Low | H17R |
T19 | Amidation | 0.97 | High | T19M |
R33 | Proteolytic cleavage | 0.67 | Low | R33H, R33P, R33L |
E42 | Proteolytic cleavage | 0.79 | Medium | E42A |
D47 | Proteolytic cleavage | 0.62 | Low | D47N, D47Y |
S50 | Proteolytic cleavage | 0.75 | Medium | S50P |
D67 | Proteolytic cleavage | 0.8 | Medium | D67N |
R76 | Proteolytic cleavage | 0.55 | Low | R76H, R76G |
G94 | Proteolytic cleavage | 0.67 | Low | G94A |
H98 | Proteolytic cleavage | 0.92 | High | H98Q |
R101 | Proteolytic cleavage | 0.95 | High | R101P |
G143 | Proteolytic cleavage | 0.78 | Medium | G143R, G143E |
R147 | Proteolytic cleavage | 0.75 | Medium | R147Q, R147W |
T148 | Proteolytic cleavage | 0.55 | Low | T148I |
K156 | SUMOylation | 0.52 | Low | K156Q |
G172 | Proteolytic cleavage | 0.52 | Low | G172D, G172S |
P187 | Hydroxylation | 0.57 | Low | P187L, P187S |
P197 | Hydroxylation | 0.64 | Medium | P197S |