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Table 1 Effect of high-risk nsSNPs in GJA3 gene on post translational modification sites predicted by ModPred tool

From: In silico analysis of non-synonymous single nucleotide polymorphisms (nsSNPs) in the human GJA3 gene associated with congenital cataract

Residue Modification Score Confidence High-risk nsSNP
G2 N-terminal acetylation 0.53 Low G2D, G2S
Proteolytic cleavage 0.52 Low
D3 Proteolytic cleavage 0.7 Medium D3H, D3Y
S5 Proteolytic cleavage 0.59 Low S5R
H17 Proteolytic cleavage 0.51 Low H17R
T19 Amidation 0.97 High T19M
R33 Proteolytic cleavage 0.67 Low R33H, R33P, R33L
E42 Proteolytic cleavage 0.79 Medium E42A
D47 Proteolytic cleavage 0.62 Low D47N, D47Y
S50 Proteolytic cleavage 0.75 Medium S50P
D67 Proteolytic cleavage 0.8 Medium D67N
R76 Proteolytic cleavage 0.55 Low R76H, R76G
G94 Proteolytic cleavage 0.67 Low G94A
H98 Proteolytic cleavage 0.92 High H98Q
R101 Proteolytic cleavage 0.95 High R101P
G143 Proteolytic cleavage 0.78 Medium G143R, G143E
R147 Proteolytic cleavage 0.75 Medium R147Q, R147W
T148 Proteolytic cleavage 0.55 Low T148I
K156 SUMOylation 0.52 Low K156Q
G172 Proteolytic cleavage 0.52 Low G172D, G172S
P187 Hydroxylation 0.57 Low P187L, P187S
P197 Hydroxylation 0.64 Medium P197S