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Fig. 2 | BMC Molecular and Cell Biology

Fig. 2

From: Differential contribution of p300 and CBP to regulatory element acetylation in mESCs

Fig. 2

Chromatin Accessibility Is Independent of CBP/p300 Levels in mESCs. a, c ATAC-seq levels at H3K27ac-enriched regions in mESCs expressing scramble control (Ctl) shRNA compared with a p300 shRNA (p300 KD) or c CBP shRNA (CBP KD). Blue and red dots represent regions with differential ATAC-seq signal at which read density increased or decreased by 2-fold or more (FDR < 0.05), respectively, in two independent biological replicates. b, d Fold-change ratio (log2) of ATAC-seq enrichment at promoters and enhancers in mESCs expressing scramble control (Ctl) shRNA compared with b p300 shRNA (p300 KD) or d CBP shRNA (CBP KD). Data to the right of log2(0) = 1 indicate regions with increased ATAC-seq signal after acetyltransferase knockdown, while data to the left indicate regions with reduced ATAC-seq signal

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