Fig. 5
From: Role of tumor cell senescence in non-professional phagocytosis and cell-in-cell structure formation
Kaplan Meier plots for overall survival, metastasis free survival and local recurrence-free survival for the cohort of patients (a) of which tissue micro arrays from pretherapeutic biopsies and (b) of post-RCT tumor resection were available. c Example of a micro array spot of rectal carcinoma tissue with a diameter of 2 mm that was immunohistochemically double stained by nuclear anti-H3K9me3 (blue, senescent) and anti-E-Cadherin (red membranous). Arrows indicating cell-in-cell events. d Individual cell-in-cell events. e Frequency of counted intraepithelial senescent cells/mm2 of patients in pre-RCT biopsy and post-RCT central tumor, invasive tumor front and normal tissue. f Frequency of counted intraepithelial cell-in-cell phenomena/mm2 in patients in pre-RCT biopsy and post-RCT central tumor, invasive tumor front and normal tissue area. Differences between groups were analyzed by unpaired Student’s t-test