Fig. 3

DNA damage inhibits MDMX suppression of p53 protein expression. MDM2487/487 MEFs were treated with empty vector (EV) or MDMX-expression lentiviral constructs for 48 h prior to lysis. For DNA damage conditions, MEF cells were treated with 1μg/mL doxorubicin for four hours, or 10 Gy ionizing irradiation (IR) for six hours prior to lysis and immunoblotting