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Fig. 3 | BMC Molecular and Cell Biology

Fig. 3

From: Intercellular transfer of mitochondrial DNA carrying metastasis-enhancing pathogenic mutations from high- to low-metastatic tumor cells and stromal cells via extracellular vesicles

Fig. 3

Effect of GW4869 and tipifarnib on intercellular transfer of mitochondria-related vesicles. (a) mtGFP-labeled A11 cells (A11-mtGFP) and MTDR-labeled P29 cells (P29-MTDR) were cocultured in the presence or absence of 10 μM GW4869 or 1 μM tipifarnib for 24 h and observed under a laser confocal microscope. Scale bars: 20 μm. (b) Semi-quantification of intercellular transfer of mitochondria-related vesicles. The number of green- and red-double positive cells per total number of cells in the images (n = 4, 5 and 6 images for DMSO, GW4869 and Tipifarnib group, respectively) was counted

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BMC Molecular and Cell Biology

ISSN: 2661-8850

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