Fig. 3
From: Structural insights into the non-inhibitory mechanism of the anti-EGFR EgB4 nanobody
EgB4 nanobody interacts with EGFR domains I and II. A The CDR3 of EgB4 engages EGFR domains I and II while CDR2 of EgB4 binds to EGFR domain I. Residues involved in the interaction are shown in stick representation. Electrostatic and hydrogen bonding interactions are indicated by black and yellow dotted lines, respectively. Inset shows the EGFR-EgB4-EGF complex in surface representation. B-D Open book view of the EGFR-EgB4 complex with the interface delimited in black, colored by domains (B), hydrophobicity (C) and electrostatic potential (D)