Skip to main content
Fig. 1 | BMC Molecular and Cell Biology

Fig. 1

From: Mesenchymal stem cells- derived exosomes inhibit the expression of Aquaporin-5 and EGFR in HCT-116 human colorectal carcinoma cell line

Fig. 1

AQP5 and EGFR interaction in tumor biology. AQP5 induces extracellular receptor kinase (ERK1/2) pathway activation via activation of the epidermal growth factor receptor (EGFR), leading to facilitating tumor proliferation and metastasis. Besides, AQP5 is phosphorylated followed by binding to the SH3 domain of Src to promote epidermal mesenchymal transition (EMT) activity in tumor cells

Back to article page

BMC Molecular and Cell Biology

ISSN: 2661-8850

Contact us