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Fig. 2 | BMC Molecular and Cell Biology

Fig. 2

From: Exogenous 8-hydroxydeoxyguanosine attenuates doxorubicin-induced cardiotoxicity by decreasing pyroptosis in H9c2 cardiomyocytes

Fig. 2

Exogenous 8-OHdG decreases the expression of cardiotoxicity-related markers in DOX-treated H9c2 cells. H9c2 cells were treated with 1 μM DOX and 100 or 250 μg/mL 8-OHdG for 24 h. Quantitative real-time PCR for ANP, BNP, GATA4, and GATA6 in DOX and 8-OHdG treated H9c2 cells. CTL, control; DOX, doxorubicin; 8-OHdG, 8-hydroxydeoxyguanosine; ANP, atrial natriuretic peptide; BNP, brain natriuretic peptide. ***P < 0.001 and ****P < 0.0001 versus control; #P < 0.05, ##P < 0.01, and ###P < 0.001 versus DOX

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BMC Molecular and Cell Biology

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