Fig. 4

The target genes prediction and analysis of miR-520c-3p. A The target genes of miR-520c-3p were predicted by miRDB, miRWalk, TargetScan and starbase databases. B The expression levels of SNX5 in HNSC was obtained from UALCAN database. C SNX5 expression level was positively related to the different advanced pathological stages of OSCC in Oncomine database. 0: benign tumor, I/II: tumor grade I/II, III/IV: tumor grade III/IV. D SNX5 expression was increased in oral cancers in Pyeon Multi-cancer datasets in Oncomine database. 1: normal, 2: oral cavity carcinoma, 3: tongue carcinoma, 4: floor of the mouth carcinoma. E-H SNX5 expression levels were analyzed in oral cancers in Oncomine database (E-H). E Oral Cavity Squamous Cell Carcinoma in Peng Head-Neck. F Oral Cavity Squamous Cell Carcinoma epithelia in Toruner Head-Neck. G Tongue Squamous Cell Carcinoma in Ye Head-Neck. H Oral Cavity Squamous Cell Carcinoma in Peng Head-Neck 2. I, J High expression of SNX5 was associated with poor prognosis of OSCC patients in UALCAN and Kaplan Meier Plotter databases, respectively.*P < 0.05, **P < 0.01 and ***P < 0.001