Fig. 2

Structural analysis of Ancestral ^T−allele DNA- SOX2 ^(HMG) complex. A Topological model for SOX2 ^(HMG) binding to ancestral ^T−allele DNA shown as semi-transparent surface and ribbons. B The zoomed image illustrates the interface between the residues of SOX2 ^(HMG) and corresponding nucleotides. Hydrogen bonds are shown by black dotted lines with calculated distances in angstrom (Å). C Schematic diagram depicts interactions between Ancestral ^T−allele DNA- SOX2 ^(HMG) complex. Nucleotides (red) are interacting with amino acid residues (green) of SOX2 ^(HMG) through hydrogen bonds (dotted lines) and Vander walls (solid lines). The DNA strands are displayed as orange. Cyan color shows the position of nucleotide variant in SOX2 binding site. Images were obtained from DNAproDB