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  1. The formylpeptide receptor family members FPR and FPRL1, expressed in myeloid phagocytes, belong to the G-protein coupled seven transmembrane receptor family (GPCRs). They share a high degree of sequence simil...

    Authors: Huamei Fu, Lena Björkman, Paul Janmey, Anna Karlsson, Jennie Karlsson, Charlotta Movitz and Claes Dahlgren
    Citation: BMC Cell Biology 2004 5:50
    Content type: Research article Published on:

  2. A number of proteins accumulate in the spindle midzone and midbody of dividing animal cells. Besides proteins essential for cytokinesis, there are also components essential for interphase functions, suggesting...

    Authors: Maki Murata-Hori, Greenfield Sluder and Yu-li Wang
    Citation: BMC Cell Biology 2004 5:49
    Content type: Research article Published on:

  3. Through in vivo loss-of-function studies, vertebrate members of the Male abnormal 21 (mab-21) gene family have been implicated in gastrulation, neural tube formation and eye morphogenesis. Despite mounting eviden...

    Authors: Danila Baldessari, Aurora Badaloni, Renato Longhi, Vincenzo Zappavigna and G Giacomo Consalez
    Citation: BMC Cell Biology 2004 5:48
    Content type: Research article Published on:

  4. Fibroblasts, as connective tissue cells, are able to transform into another cell type including smooth muscle cells. α1A-adrenergic receptor (α1A-AR) stimulation in rat-1 fibroblasts is coupled to cAMP production...

    Authors: Abdelwahab E Saeed, Jean-Hugues Parmentier and Kafait U Malik
    Citation: BMC Cell Biology 2004 5:47
    Content type: Research article Published on:

  5. Recent interest in the function of the nuclear lamina has been provoked by the discovery of lamin A/C mutations in the laminopathy diseases. However, it is not understood why mutations in lamin A give such a r...

    Authors: Susan Gilchrist, Nick Gilbert, Paul Perry, Cecilia Östlund, Howard J Worman and Wendy A Bickmore
    Citation: BMC Cell Biology 2004 5:46
    Content type: Research article Published on:

  6. The dynamics of nuclear organization, nuclear bodies and RNPs in particular has been the focus of many studies. To understand their function, knowledge of their spatial nuclear position and temporal translocat...

    Authors: Christian P Bacher, Michaela Reichenzeller, Chaitanya Athale, Harald Herrmann and Roland Eils
    Citation: BMC Cell Biology 2004 5:45
    Content type: Research article Published on:

  7. Between cell divisions the chromatin fiber of each chromosome is restricted to a subvolume of the interphase cell nucleus called chromosome territory. The internal organization of these chromosome territories ...

    Authors: Sonja Stadler, Verena Schnapp, Robert Mayer, Stefan Stein, Christoph Cremer, Constanze Bonifer, Thomas Cremer and Steffen Dietzel
    Citation: BMC Cell Biology 2004 5:44
    Content type: Research article Published on:

  9. The Coxsackie and adenovirus receptor (CAR) has a restricted expression pattern in the adult. In skeletal muscle, although CAR is expressed in immature fibers, its transcript levels are barely detectable in ma...

    Authors: Christian A Shaw, Paul C Holland, Michael Sinnreich, Carol Allen, Kerstin Sollerbrant, George Karpati and Josephine Nalbantoglu
    Citation: BMC Cell Biology 2004 5:42
    Content type: Research article Published on:

  10. Viruses are obligate intracellular parasites that rely upon the host cell for different steps in their life cycles. The characterization of cellular genes required for virus infection and/or cell killing will ...

    Authors: Edward L Organ, Jinsong Sheng, H Earl Ruley and Donald H Rubin
    Citation: BMC Cell Biology 2004 5:41
    Content type: Research article Published on:

  11. Checkpoint mechanisms prevent cell cycle transitions until previous events have been completed or damaged DNA has been repaired. In fission yeast, checkpoint mechanisms are known to regulate entry into mitosis...

    Authors: Esben A Nilssen, Marianne Synnes, Tonje Tvegård, Heidi Vebø, Erik Boye and Beáta Grallert
    Citation: BMC Cell Biology 2004 5:40
    Content type: Research article Published on:

  12. Erythroid nuclear cells (ENC) of the bone marrow (BM) have not previously been considered as important producers of wide spectrum of haemo- and immunoregulatory cytokines. The aim of the current work was to co...

    Authors: Sergey V Sennikov, Tatyana V Injelevskaya, Sergey V Krysov, Alexandr N Silkov, Igor B Kovinev, Natalya J Dyachkova, Anton N Zenkov, Mary I Loseva and Vladimir A Kozlov
    Citation: BMC Cell Biology 2004 5:39
    Content type: Research article Published on:

  13. The Janus kinase (JAK) cascade is an essential and well-conserved pathway required to transduce signals for a variety of ligands in both vertebrates and invertebrates. While activation of the pathway is essent...

    Authors: Jason S Rawlings, Gabriela Rennebeck, Susan MW Harrison, Rongwen Xi and Douglas A Harrison
    Citation: BMC Cell Biology 2004 5:38
    Content type: Research article Published on:

  16. Conlon and Raff propose that mammalian cells grow linearly during the division cycle. According to Conlon and Raff, cells growing linearly do not need a size checkpoint to maintain a constant distribution of c...

    Authors: Stephen Cooper
    Citation: BMC Cell Biology 2004 5:35
    Content type: Debate Published on:

  17. Research on olfactory G-protein coupled receptors (GPCRs) has been severely impeded by poor functional expression in heterologous systems. Previously, we demonstrated that inefficient olfactory receptor (OR) e...

    Authors: Min Lu, Lena Staszewski, Fernando Echeverri, Hong Xu and Bryan D Moyer
    Citation: BMC Cell Biology 2004 5:34
    Content type: Research article Published on:

  19. Viruses are obligate intracellular parasites and rely upon the host cell for different steps in their life cycles. The characterization of cellular genes required for virus infection and/or cell killing will b...

    Authors: Jinsong Sheng, Edward L Organ, Chuanming Hao, K Sam Wells, H Earl Ruley and Donald H Rubin
    Citation: BMC Cell Biology 2004 5:32
    Content type: Research article Published on:

  20. The guanine nucleotide exchange factor C3G (RapGEF1) along with its effector proteins participates in signaling pathways that regulate eukaryotic cell proliferation, adhesion, apoptosis and embryonic developme...

    Authors: Vegesna Radha, Ajumeera Rajanna and Ghanshyam Swarup
    Citation: BMC Cell Biology 2004 5:31
    Content type: Research article Published on:

  22. Vacuolar H+-ATPases are large protein complexes of more than 700 kDa that acidify endomembrane compartments and are part of the secretory system of eukaryotic cells. They are built from 14 different (VHA)-subunit...

    Authors: Christoph Kluge, Thorsten Seidel, Susanne Bolte, Shanti S Sharma, Miriam Hanitzsch, Beatrice Satiat-Jeunemaitre, Joachim Roß, Markus Sauer, Dortje Golldack and Karl-Josef Dietz
    Citation: BMC Cell Biology 2004 5:29
    Content type: Research article Published on:

  23. The calcium activated protein phosphatase 2B, also known as calcineurin, has been implicated as a cell signaling molecule involved with transduction of physiological signals (free cytosolic Ca2+) into molecular s...

    Authors: Robert J Talmadge, Jeffrey S Otis, Matthew R Rittler, Nicole D Garcia, Shelly R Spencer, Simon J Lees and Francisco J Naya
    Citation: BMC Cell Biology 2004 5:28
    Content type: Research article Published on:

  24. The dual specificity phosphatase Cdc14 has been shown to be a critical regulator of late mitotic events in several eukaryotes, including S. cerevisiae, S. pombe. C. elegans and H. sapiens. However, Cdc14 homologs...

    Authors: Brett K Kaiser, Maxence V Nachury, Bryan E Gardner and Peter K Jackson
    Citation: BMC Cell Biology 2004 5:27
    Content type: Research article Published on:

  25. Apoptotic cell death plays an essential part in embryogenesis, development and maintenance of tissue homeostasis in metazoan animals. The culmination of apoptosis in vivo is the phagocytosis of cellular corpses. ...

    Authors: Mihai Cikala, Olga Alexandrova, Charles N David, Matthias Pröschel, Beate Stiening, Patrick Cramer and Angelika Böttger
    Citation: BMC Cell Biology 2004 5:26
    Content type: Research article Published on:

  26. We investigated how the synthesis of cAMP, stimulated by isoproterenol acting through β-adrenoreceptors and Gs, is strongly amplified by simultaneous incubation with baclofen. Baclofen is an agonist of δ-aminobut...

    Authors: Alain Robichon, Sylvette Tinette, Cédric Courtial and Franck Pelletier
    Citation: BMC Cell Biology 2004 5:25
    Content type: Research article Published on:

  28. The transport of intra-cellular particles by microtubules is a major biological function. Under appropriate in vitro conditions, microtubule preparations behave as a 'complex' system and show 'emergent' phenomena...

    Authors: Nicolas Glade, Jacques Demongeot and James Tabony
    Citation: BMC Cell Biology 2004 5:23
    Content type: Research article Published on:

  29. The peptidyl-prolyl isomerase Pin1 recently revealed itself as a new player in the regulation of protein function by phosphorylation. Pin1 isomerizes the peptide bond of specific phosphorylated serine or threo...

    Authors: Alexandra L Albert, Sébastien B Lavoie and Michel Vincent
    Citation: BMC Cell Biology 2004 5:22
    Content type: Research article Published on:

  30. Cytochalasin B does not directly activate the oxygen-radical-producing NADPH oxidase activity of neutrophils but transfers desensitized G-protein coupled receptors (GPCR) into an active signaling state by unco...

    Authors: Johan Bylund, Sara Pellmé, Huamei Fu, Ulf-Henrik Mellqvist, Kristoffer Hellstrand, Anna Karlsson and Claes Dahlgren
    Citation: BMC Cell Biology 2004 5:21
    Content type: Research article Published on:

  31. The Transforming Growth Factor-β (TGF-β) regulates myriad cellular events by signaling through members of the Smad family signal transducers. As a key signal transducer of TGF-β, Smad3 exhibits the property of...

    Authors: Claire Nourry, Lola Maksumova, Mona Pang, Xiaohong Liu and Tongwen Wang
    Citation: BMC Cell Biology 2004 5:20
    Content type: Research article Published on:

  32. Gelsolin, an actin capping protein of osteoclast podosomes, has a unique function in regulating assembly and disassembly of the podosome actin filament. Previously, we have reported that osteopontin (OPN) bind...

    Authors: Rajat S Biswas, De Anna Baker, Keith A Hruska and Meenakshi A Chellaiah
    Citation: BMC Cell Biology 2004 5:19
    Content type: Research article Published on:

  33. Golgins are coiled-coil proteins associated with the Golgi apparatus, that are believed to be involved in the tethering of vesicles and the stacking of cisternae, as well as other functions such as cytoskeleta...

    Authors: Yael Fridmann-Sirkis, Symeon Siniossoglou and Hugh RB Pelham
    Citation: BMC Cell Biology 2004 5:18
    Content type: Research article Published on:

  34. Projectin is a giant modular protein of Drosophila muscles and a key component of the elastic connecting filaments (C-filaments), which are involved in stretch activation in insect Indirect Flight Muscles. It is ...

    Authors: Agnes Ayme-Southgate, Christophe Bounaix, Theresa E Riebe and Richard Southgate
    Citation: BMC Cell Biology 2004 5:17
    Content type: Research article Published on:

  36. The mannose 6-phosphate/insulin-like growth factor-II receptor (M6P/IGF2R) is a multi-functional protein that has been implicated in regulation of cell growth and apoptosis. Cardiac myocytes express relatively...

    Authors: Zhihong Chen, Yinlin Ge and Jing X Kang
    Citation: BMC Cell Biology 2004 5:15
    Content type: Research article Published on:

  38. It is known that "second-hand" cigarette smoke leads to abnormal tissue repair and remodelling but the cellular mechanisms involved in these adverse effects are not well understood. Fibroblasts play a major ro...

    Authors: Lina S Wong, Harry Miguel Green, Jo Ellen Feugate, Madhav Yadav, Eugene A Nothnagel and Manuela Martins-Green
    Citation: BMC Cell Biology 2004 5:13
    Content type: Research article Published on:

  39. The autosomal dominant form of Emery-Dreifuss muscular dystrophy (AD-EDMD) is caused by mutations in the gene encoding for the lamins A and C (LMNA). Lamins are intermediate filament proteins which form the nu...

    Authors: Beate Reichart, Ruth Klafke, Christine Dreger, Eleonora Krüger, Isabell Motsch, Andrea Ewald, Jochen Schäfer, Heinz Reichmann, Clemens R Müller and Marie-Christine Dabauvalle
    Citation: BMC Cell Biology 2004 5:12
    Content type: Research article Published on:

  40. α1-antitrypsin (AAT) is one of the major serine proteinase inhibitors controlling proteinases in many biological pathways. There is increasing evidence that AAT is able to exert other than antiproteolytic effe...

    Authors: Ruta Aldonyte, Lennart Jansson and Sabina Janciauskiene
    Citation: BMC Cell Biology 2004 5:11
    Content type: Research article Published on:

  42. Opitz G/BBB syndrome is a genetic disorder characterized by developmental midline abnormalities, such as hypertelorism, cleft palate, and hypospadias. The gene responsible for the X-linked form of this disease, M...

    Authors: Caterina Berti, Bianca Fontanella, Rosa Ferrentino and Germana Meroni
    Citation: BMC Cell Biology 2004 5:9
    Content type: Research article Published on:

  43. "Protein-trap" is a method that allows epitope-tagging of endogenous proteins. This method allows for the identification of endogenously expressed proteins that exhibit specific localization of interest. This ...

    Authors: Olga O Sineshchekova, Toshimitsu Kawate, Oleksandr V Vdovychenko and Thomas N Sato
    Citation: BMC Cell Biology 2004 5:8
    Content type: Methodology article Published on:

  44. Transfection agents comprised of cationic lipid preparations are widely used to transfect cell lines in culture with specific recombinant complementary DNA molecules. We have found that cells in culture are of...

    Authors: Camilla Pramfalk, Johanna Lanner, Monica Andersson, Eva Danielsson, Christina Kaiser, Ing-Marie Renström, Malin Warolén and Stephen R James
    Citation: BMC Cell Biology 2004 5:7
    Content type: Research article Published on:

  45. Published work suggests that some types of endothelial cells undergo apoptosis in response to ligation of the receptor Fas (CD95, APO1) but other types are resistant. Because heterogeneity among endothelial ce...

    Authors: Gerasimos Filippatos, Edmund Ang, Claudia Gidea, Erhan Dincer, Rongqi Wang and Bruce D Uhal
    Citation: BMC Cell Biology 2004 5:6
    Content type: Research article Published on:

  47. Phenylephrine (PHE), an α1 adrenergic receptor agonist, increases phospholipase D (PLD) activity, independent of classical and novel protein kinase C (PKC) isoforms, in rat-1 fibroblasts expressing α1A adrenergic...

    Authors: Jean-Hugues Parmentier, Gautam K Gandhi, Monique T Wiggins, Abdelwahab E Saeed, Sylvain G Bourgoin and Kafait U Malik
    Citation: BMC Cell Biology 2004 5:4
    Content type: Research article Published on:

  49. Transforming growth factor-βs (TGF-βs), bone morphogenetic proteins (BMPs) and activins are important regulators of developmental cell growth and differentiation. Signaling by these factors is mediated chiefly...

    Authors: Nieves Ibarrola, Irina Kratchmarova, Daisuke Nakajima, William P Schiemann, Aristidis Moustakas, Akhilesh Pandey and Matthias Mann
    Citation: BMC Cell Biology 2004 5:2
    Content type: Research article Published on:

  50. Upon serial passaging of mouse skeletal muscle cells, a small number of cells will spontaneously develop the ability to proliferate indefinitely while retaining the ability to differentiate into multinucleate ...

    Authors: Jonathan A Nowak, Jonathan Malowitz, Mahasweta Girgenrath, Christine A Kostek, Amanda J Kravetz, Janice A Dominov and Jeffrey Boone Miller
    Citation: BMC Cell Biology 2004 5:1
    Content type: Research article Published on:
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