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  1. Two-photon-excitation fluorescence lifetime imaging (2P-FLIM) was used to investigate the association of protein kinase C alpha (PKCα) with caveolin in CHO cells. PKCα is found widely in the cytoplasm and nucl...

    Authors: Christopher D Stubbs, Stanley W Botchway, Simon J Slater and Anthony W Parker
    Citation: BMC Cell Biology 2005 6:22
  2. Recent studies indicate that the G protein-coupled receptor (GPCR) signaling machinery can serve as a direct target of reactive oxygen species, including nitric oxide (NO) and S-nitrosothiols (RSNOs). To gain ...

    Authors: Tarja Kokkola, Juha R Savinainen, Kati S Mönkkönen, Montse Durán Retamal and Jarmo T Laitinen
    Citation: BMC Cell Biology 2005 6:21
  3. Human cell types respond differently to infection by human immunodeficiency virus (HIV). Defining specific interactions between host cells and viral proteins is essential in understanding how viruses exploit c...

    Authors: Susanne Kramer-Hämmerle, Francesca Ceccherini-Silberstein, Christian Bickel, Horst Wolff, Michelle Vincendeau, Thomas Werner, Volker Erfle and Ruth Brack-Werner
    Citation: BMC Cell Biology 2005 6:20
  4. Time-lapse microscopic imaging provides a powerful approach for following changes in cell phenotype over time. Visible responses of whole cells can yield insight into functional changes that underlie physiolog...

    Authors: Alfred Bahnson, Charalambos Athanassiou, Douglas Koebler, Lei Qian, Tongying Shun, Donna Shields, Hui Yu, Hong Wang, Julie Goff, Tao Cheng, Raymond Houck and Lex Cowsert
    Citation: BMC Cell Biology 2005 6:19
  5. A number of transgenic mice carrying different deletions in the Locus Control Region (LCR) of the mouse tyrosinase (Tyr) gene have been developed and analysed in our laboratory. We require melanocytes from these ...

    Authors: Alfonso Lavado, Ander Matheu, Manuel Serrano and Lluís Montoliu
    Citation: BMC Cell Biology 2005 6:18
  6. EB1 is a microtubule tip-associated protein that interacts with the APC tumour suppressor protein and the p150glued subunit of dynactin. We previously reported that an EB1 deletion mutant that retains both of ...

    Authors: Nick P Riess, Kelly Milward, Tracy Lee, Matthew Adams, Jon M Askham and Ewan E Morrison
    Citation: BMC Cell Biology 2005 6:17
  7. Splicing variants of human cathepsinB primary transcripts (CB(-2,3)) result in an expression product product which lacks the signal peptide and parts of the propeptide. This naturally truncated Δ51CB is thus unab...

    Authors: Felix Bestvater, Claudia Dallner and Eberhard Spiess
    Citation: BMC Cell Biology 2005 6:16
  8. The small GTPase rab1a and its isoform rab1b are essential regulating components in the vesicle transport between the ER and the Golgi apparatus. Rab1 is thought to act as a molecular switch and can change bet...

    Authors: Michael Bayer, Julia Fischer, Joachim Kremerskothen, Edith Ossendorf, Theodoros Matanis, Magdalena Konczal, Thomas Weide and Angelika Barnekow
    Citation: BMC Cell Biology 2005 6:15
  9. Stimulation of Dictyostelium discoideum with cAMP evokes an elevation of the cytosolic free Ca2+ concentration ([Ca2+]i). The [Ca2+]i-change is composed of liberation of stored Ca2+ and extracellular Ca2+-entry. ...

    Authors: Ralph H Schaloske, Daniel F Lusche, Karen Bezares-Roder, Kathrin Happle, Dieter Malchow and Christina Schlatterer
    Citation: BMC Cell Biology 2005 6:13
  10. Differentiating Dictyostelium discoideum amoebae respond upon cAMP-stimulation with an increase in the cytosolic free Ca2+ concentration ([Ca2+]i) that is composed of liberation of stored Ca2+ and extracellular C...

    Authors: Daniel F Lusche, Karen Bezares-Roder, Kathrin Happle and Christina Schlatterer
    Citation: BMC Cell Biology 2005 6:12
  11. The Scar/WAVE family of proteins mediates signals to actin assembly by direct activation of the Arp2/3 complex. These proteins have been characterised as major regulators of lamellipodia formation downstream o...

    Authors: Craig F Stovold, Thomas H Millard and Laura M Machesky
    Citation: BMC Cell Biology 2005 6:11
  12. Bacterial actin-like proteins have been shown to perform essential functions in several aspects of cellular physiology. They affect cell growth, cell shape, chromosome segregation and polar localization of pro...

    Authors: Hervé Joël Defeu Soufo and Peter L Graumann
    Citation: BMC Cell Biology 2005 6:10
  13. The growth of new blood vessels in adult life requires the initiation of endothelial cell migration and proliferation from pre-existing vessels in addition to the recruitment and differentiation of circulating...

    Authors: Salman Rahman, Yatin Patel, Jacqueline Murray, Kirti V Patel, Rushika Sumathipala, Michael Sobel and Errol S Wijelath
    Citation: BMC Cell Biology 2005 6:8
  14. Gliomas are "intraparenchymally metastatic" tumors, invading the brain in a non-destructive way that suggests cooperation between glioma cells and their environment. Recent studies using an engineered rodent C...

    Authors: Roxane Oliveira, Christo Christov, Jean Sébastien Guillamo, Sophie de Boüard, Stéphane Palfi, Laurent Venance, Marcienne Tardy and Marc Peschanski
    Citation: BMC Cell Biology 2005 6:7
  15. Human α-galactosidase A (α-GAL) and α-N-acetylgalactosaminidase (α-NAGA) are presumed to share a common ancestor. Deficiencies of these enzymes cause two well-characterized human lysosomal storage disorders (L...

    Authors: Jana Hujová, Jakub Sikora, Robert Dobrovolný, Helena Poupětová, Jana Ledvinová, Marta Kostrouchová and Martin Hřebíček
    Citation: BMC Cell Biology 2005 6:5
  16. IEC-18 cells are a non-transformed, immortal cell line derived from juvenile rat ileal crypt cells. They may have experimental advantages over tumor-derived gastrointestinal lineages, including preservation of...

    Authors: Phillip V Gordon, Jessica B Paxton and Nena S Fox
    Citation: BMC Cell Biology 2005 6:2
  17. At sites of cell adhesion, proteins exist that not only perform structural tasks but also have a signaling function. Previously, we found that the Lipoma Preferred Partner (LPP) protein is localized at sites o...

    Authors: Marleen MR Petit, Sandra MP Meulemans, Philippe Alen, Torik AY Ayoubi, Erik Jansen and Wim JM Van de Ven
    Citation: BMC Cell Biology 2005 6:1
  18. The formylpeptide receptor family members FPR and FPRL1, expressed in myeloid phagocytes, belong to the G-protein coupled seven transmembrane receptor family (GPCRs). They share a high degree of sequence simil...

    Authors: Huamei Fu, Lena Björkman, Paul Janmey, Anna Karlsson, Jennie Karlsson, Charlotta Movitz and Claes Dahlgren
    Citation: BMC Cell Biology 2004 5:50
  19. A number of proteins accumulate in the spindle midzone and midbody of dividing animal cells. Besides proteins essential for cytokinesis, there are also components essential for interphase functions, suggesting...

    Authors: Maki Murata-Hori, Greenfield Sluder and Yu-li Wang
    Citation: BMC Cell Biology 2004 5:49
  20. Through in vivo loss-of-function studies, vertebrate members of the Male abnormal 21 (mab-21) gene family have been implicated in gastrulation, neural tube formation and eye morphogenesis. Despite mounting eviden...

    Authors: Danila Baldessari, Aurora Badaloni, Renato Longhi, Vincenzo Zappavigna and G Giacomo Consalez
    Citation: BMC Cell Biology 2004 5:48
  21. Fibroblasts, as connective tissue cells, are able to transform into another cell type including smooth muscle cells. α1A-adrenergic receptor (α1A-AR) stimulation in rat-1 fibroblasts is coupled to cAMP production...

    Authors: Abdelwahab E Saeed, Jean-Hugues Parmentier and Kafait U Malik
    Citation: BMC Cell Biology 2004 5:47
  22. Recent interest in the function of the nuclear lamina has been provoked by the discovery of lamin A/C mutations in the laminopathy diseases. However, it is not understood why mutations in lamin A give such a r...

    Authors: Susan Gilchrist, Nick Gilbert, Paul Perry, Cecilia Östlund, Howard J Worman and Wendy A Bickmore
    Citation: BMC Cell Biology 2004 5:46
  23. The dynamics of nuclear organization, nuclear bodies and RNPs in particular has been the focus of many studies. To understand their function, knowledge of their spatial nuclear position and temporal translocat...

    Authors: Christian P Bacher, Michaela Reichenzeller, Chaitanya Athale, Harald Herrmann and Roland Eils
    Citation: BMC Cell Biology 2004 5:45
  24. Between cell divisions the chromatin fiber of each chromosome is restricted to a subvolume of the interphase cell nucleus called chromosome territory. The internal organization of these chromosome territories ...

    Authors: Sonja Stadler, Verena Schnapp, Robert Mayer, Stefan Stein, Christoph Cremer, Constanze Bonifer, Thomas Cremer and Steffen Dietzel
    Citation: BMC Cell Biology 2004 5:44
  25. The Coxsackie and adenovirus receptor (CAR) has a restricted expression pattern in the adult. In skeletal muscle, although CAR is expressed in immature fibers, its transcript levels are barely detectable in ma...

    Authors: Christian A Shaw, Paul C Holland, Michael Sinnreich, Carol Allen, Kerstin Sollerbrant, George Karpati and Josephine Nalbantoglu
    Citation: BMC Cell Biology 2004 5:42
  26. Viruses are obligate intracellular parasites that rely upon the host cell for different steps in their life cycles. The characterization of cellular genes required for virus infection and/or cell killing will ...

    Authors: Edward L Organ, Jinsong Sheng, H Earl Ruley and Donald H Rubin
    Citation: BMC Cell Biology 2004 5:41
  27. Checkpoint mechanisms prevent cell cycle transitions until previous events have been completed or damaged DNA has been repaired. In fission yeast, checkpoint mechanisms are known to regulate entry into mitosis...

    Authors: Esben A Nilssen, Marianne Synnes, Tonje Tvegård, Heidi Vebø, Erik Boye and Beáta Grallert
    Citation: BMC Cell Biology 2004 5:40
  28. Erythroid nuclear cells (ENC) of the bone marrow (BM) have not previously been considered as important producers of wide spectrum of haemo- and immunoregulatory cytokines. The aim of the current work was to co...

    Authors: Sergey V Sennikov, Tatyana V Injelevskaya, Sergey V Krysov, Alexandr N Silkov, Igor B Kovinev, Natalya J Dyachkova, Anton N Zenkov, Mary I Loseva and Vladimir A Kozlov
    Citation: BMC Cell Biology 2004 5:39
  29. The Janus kinase (JAK) cascade is an essential and well-conserved pathway required to transduce signals for a variety of ligands in both vertebrates and invertebrates. While activation of the pathway is essent...

    Authors: Jason S Rawlings, Gabriela Rennebeck, Susan MW Harrison, Rongwen Xi and Douglas A Harrison
    Citation: BMC Cell Biology 2004 5:38
  30. Conlon and Raff propose that mammalian cells grow linearly during the division cycle. According to Conlon and Raff, cells growing linearly do not need a size checkpoint to maintain a constant distribution of c...

    Authors: Stephen Cooper
    Citation: BMC Cell Biology 2004 5:35
  31. Research on olfactory G-protein coupled receptors (GPCRs) has been severely impeded by poor functional expression in heterologous systems. Previously, we demonstrated that inefficient olfactory receptor (OR) e...

    Authors: Min Lu, Lena Staszewski, Fernando Echeverri, Hong Xu and Bryan D Moyer
    Citation: BMC Cell Biology 2004 5:34
  32. Viruses are obligate intracellular parasites and rely upon the host cell for different steps in their life cycles. The characterization of cellular genes required for virus infection and/or cell killing will b...

    Authors: Jinsong Sheng, Edward L Organ, Chuanming Hao, K Sam Wells, H Earl Ruley and Donald H Rubin
    Citation: BMC Cell Biology 2004 5:32
  33. The guanine nucleotide exchange factor C3G (RapGEF1) along with its effector proteins participates in signaling pathways that regulate eukaryotic cell proliferation, adhesion, apoptosis and embryonic developme...

    Authors: Vegesna Radha, Ajumeera Rajanna and Ghanshyam Swarup
    Citation: BMC Cell Biology 2004 5:31
  34. Vacuolar H+-ATPases are large protein complexes of more than 700 kDa that acidify endomembrane compartments and are part of the secretory system of eukaryotic cells. They are built from 14 different (VHA)-subunit...

    Authors: Christoph Kluge, Thorsten Seidel, Susanne Bolte, Shanti S Sharma, Miriam Hanitzsch, Beatrice Satiat-Jeunemaitre, Joachim Roß, Markus Sauer, Dortje Golldack and Karl-Josef Dietz
    Citation: BMC Cell Biology 2004 5:29
  35. The calcium activated protein phosphatase 2B, also known as calcineurin, has been implicated as a cell signaling molecule involved with transduction of physiological signals (free cytosolic Ca2+) into molecular s...

    Authors: Robert J Talmadge, Jeffrey S Otis, Matthew R Rittler, Nicole D Garcia, Shelly R Spencer, Simon J Lees and Francisco J Naya
    Citation: BMC Cell Biology 2004 5:28
  36. The dual specificity phosphatase Cdc14 has been shown to be a critical regulator of late mitotic events in several eukaryotes, including S. cerevisiae, S. pombe. C. elegans and H. sapiens. However, Cdc14 homologs...

    Authors: Brett K Kaiser, Maxence V Nachury, Bryan E Gardner and Peter K Jackson
    Citation: BMC Cell Biology 2004 5:27
  37. Apoptotic cell death plays an essential part in embryogenesis, development and maintenance of tissue homeostasis in metazoan animals. The culmination of apoptosis in vivo is the phagocytosis of cellular corpses. ...

    Authors: Mihai Cikala, Olga Alexandrova, Charles N David, Matthias Pröschel, Beate Stiening, Patrick Cramer and Angelika Böttger
    Citation: BMC Cell Biology 2004 5:26
  38. We investigated how the synthesis of cAMP, stimulated by isoproterenol acting through β-adrenoreceptors and Gs, is strongly amplified by simultaneous incubation with baclofen. Baclofen is an agonist of δ-aminobut...

    Authors: Alain Robichon, Sylvette Tinette, Cédric Courtial and Franck Pelletier
    Citation: BMC Cell Biology 2004 5:25

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