Dani C, Smith AG, Dessolin S, Leroy P, Staccini L, Villageois P, Darimont C, Ailhaud G: Differentiation of embryonic stem cells into adipocytes in vitro. J Cell Sci. 1997, 110: 1279-1285.
CAS
PubMed
Google Scholar
Maden M: Retinoic acid in the development, regeneration and maintenance of the nervous system. Nat Rev Neurosci. 2007, 8: 755-765. 10.1038/nrn2212.
Article
CAS
PubMed
Google Scholar
Bain G, Kitchens D, Yao M, Huettner JE, Gottlieb DI: Embryonic stem cells express neuronal properties in vitro. Dev Biol. 1995, 168 (2): 342-357. 10.1006/dbio.1995.1085.
Article
CAS
PubMed
Google Scholar
Fraichard A, Chassande O, Bilbaut G, Dehay C, Savatier P, Samarut J: In vitro differentiation of embryonic stem cells into glial cells and functional neurons. J Cell Sci. 1995, 108 (10): 3181-3188.
CAS
PubMed
Google Scholar
Guan K, Chang H, Rolletschek A, Wobus AM: Embryonic stem cell-derived neurogenesis: Retinoic acid induction and lineage selection of neuronal cells. Cell Tissue Res. 2001, 305: 171-176. 10.1007/s004410100416.
Article
CAS
PubMed
Google Scholar
Gordon MK: In vitro differentiation of embryonic stem cells. Curr Opi Cell Biol. 1995, 7: 862-869. 10.1016/0955-0674(95)80071-9.
Article
Google Scholar
Ying QL, Stavridis M, Griffiths D, Li M, Smith AG: Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture. Nat Biotechnol. 2003, 21: 183-186. 10.1038/nbt780.
Article
CAS
PubMed
Google Scholar
Marill J, Idres N, Capron CC, Nguyen E, Chabot GG: Retinoic acid metabolism and mechanism of action: a review. Curr Drug Metab. 2003, 4 (1): 1-10. 10.2174/1389200033336900.
Article
CAS
PubMed
Google Scholar
Ying QL, Smith AG: Defined conditions for neural commitment and differentiation. Methods Enzymol. 2003, 365: 327-341. full_text.
Article
CAS
PubMed
Google Scholar
Mountford P, Zevnik B, Düwel A, Nichols J, Li M, Dani C, Robertson M, Chambers I, Smith A: Dicistronic targeting constructs: Reporters and modifiers of mammalian gene expression. Proc Natl Acad Sci USA. 1994, 91 (10): 4303-4307. 10.1073/pnas.91.10.4303.
Article
PubMed Central
CAS
PubMed
Google Scholar
Wood HB, Episkopou V: Comparative expression of the mouse Sox1, Sox2 and Sox3 genes from pre-gastrulation to early somite stages. Mech Dev. 1999, 86: 197-201. 10.1016/S0925-4773(99)00116-1.
Article
CAS
PubMed
Google Scholar
Niwa H, Miyazaki J, Smith AG: Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ESCs. Nat Genet. 2000, 24: 372-376. 10.1038/74199.
Article
CAS
PubMed
Google Scholar
Takebayashi H, Yoshida S, Sugimori M, Kosako H, Kominami R, Nakafuku M, Nabeshima Y: Dynamic expression of basic helix-loop-helix Olig family members: implication of Olig2 in neuron and oligodendrocyte differentiation and identification of a new member, Olig3. Mech Dev. 2000, 99: 143-148. 10.1016/S0925-4773(00)00466-4.
Article
CAS
PubMed
Google Scholar
Apfel C, Bauer F, Crettaz M, Forni L, Kamber M, Kaufmann F, LeMotte P, Pirson W, Klaus M: A retinoic acid receptor alpha antagonist selectively counteracts retinoic acid effects. Proc Natl Acad Sci USA. 1992, 89 (15): 7129-7133. 10.1073/pnas.89.15.7129.
Article
PubMed Central
CAS
PubMed
Google Scholar
Streit A, Berliner AJ, Papanayotou C, Sirulnik A, Stern CD: Initiation of neural induction by FGF signaling before gastrulation. Nature. 2000, 406: 74-78. 10.1038/35017617.
Article
CAS
PubMed
Google Scholar
Wilson SI, Graziano E, Harland R, Jessell TM, Edlund T: An early requirement for FGF signaling in the acquisition of neural cell fate in the chick embryo. Curr Biol. 2000, 10: 421-429. 10.1016/S0960-9822(00)00431-0.
Article
CAS
PubMed
Google Scholar
Pera EM, Ikeda A, Eivers E, De Robertis EM: Integration of IGF, FGF, and anti-BMP signals via Smad1 phosphorylation in neural induction. Genes Dev. 2003, 17: 3023-3028. 10.1101/gad.1153603.
Article
PubMed Central
CAS
PubMed
Google Scholar
Mohammadi M, McMahon G, Sun L, Tang C, Hirth P, Yeh BK, Hubbard SR, Schlessinger J: Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors. Science. 1997, 276 (5314): 955-960. 10.1126/science.276.5314.955.
Article
CAS
PubMed
Google Scholar
Dai Y, Yu C, Singh V, Tang L, Wang Z, McInistry R, Dent P, Grant S: Pharmacological inhibitors of the mitogen-activated protein kinase (MAPK) kinase/MAPK cascade interact synergistically with UCN-01 to induce mitochondrial dysfunction and apoptosis in human leukemia cells. Cancer Res. 2001, 61 (13): 5106-5115.
CAS
PubMed
Google Scholar
Bain J, Plater L, Elliott M, Shpiro N, Hastie CJ, Mclauchlan H, Klevernic I, Arthur JS, Alessi DR, Cohen P: The selectivity of protein kinase inhibitors: a further update. Biochem J. 2007, 408 (3): 297-315. 10.1042/BJ20070797.
Article
PubMed Central
CAS
PubMed
Google Scholar
Stavridis MP, Smith AG: Neural differentiation of mouse embryonic stem cells. Biochem Soc Trans. 2003, 31: 45-49. 10.1042/BST0310045.
Article
CAS
PubMed
Google Scholar
Ying QL, Wray J, Nichols J, Batlle-Morera L, Doble B, Woodgett J, Cohen P, Smith AG: The ground state of embryonic stem cell self-renewal. Nature. 2008, 453 (7194): 519-523. 10.1038/nature06968.
Article
CAS
PubMed
Google Scholar
Marais R, Wynne J, Treisman R: The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain. Cell. 1993, 73 (2): 381-393. 10.1016/0092-8674(93)90237-K.
Article
CAS
PubMed
Google Scholar
Kortenjann M, Thomae O, Shaw PE: Inhibition of v-raf-dependent c-fos expression and transformation by a kinase-defective mutant of the mitogen-activated protein kinase Erk2. Mol Cell Biol. 1994, 14 (7): 4815-4824.
Article
PubMed Central
CAS
PubMed
Google Scholar
Aubert J, Dunstan H, Chambers I, Smith A: Functional gene screening in embryonic stem cells implicates Wnt antagonism in neural differentiation. Nat Biotechnol. 2002, 20: 1240-1245. 10.1038/nbt763.
Article
CAS
PubMed
Google Scholar
Murray JT, Campbell DG, Morrice N, Auld GC, Shpiro N, Marquez R, Peggie M, Bain J, Bloomberg GB, Grahammer F, Lang F, Wulff P, Kuhl D, Cohen P: Exploitation of KESTREL to identify NDRG family members as physiological substrates for SGK1 and GSK3. Biochem J. 2004, 384: 477-488. 10.1042/BJ20041057.
Article
PubMed Central
CAS
PubMed
Google Scholar
Bain G, Ray WJ, Yao M, Gottlieb DI: Retinoic acid promotes neural and represses mesodermal gene expression in mouse embryonic stem cells in culture. Biochem Biophys Res Commun. 1996, 223: 691-694. 10.1006/bbrc.1996.0957.
Article
CAS
PubMed
Google Scholar
Maden M: Role and distribution of retinoic acid during CNS development. Int Rev Cytol. 2001, 209: 1-77. full_text.
Article
CAS
PubMed
Google Scholar
Li M, Pevny L, Lovell-Badge R, Smith A: Generation of purified neural precursors from embryonic stem cells by lineage selection. Curr Biol. 1998, 8: 971-974. 10.1016/S0960-9822(98)70399-9.
Article
CAS
PubMed
Google Scholar
Corcoran J, Maden M: Nerve growth factor acts via retinoic acid synthesis to stimulate neurite outgrowth. Nat Neurosci. 1999, 2: 307-308. 10.1038/7214.
Article
CAS
PubMed
Google Scholar
Haussler M, Sidell N, Kelly M, Donaldson C, Altman A, Mangelsdorf D: Specific high affinity binding and biological action of retinoic acid in human neuroblastoma cells. Proc Natl Acad Sci USA. 1983, 80: 5525-5529. 10.1073/pnas.80.18.5525.
Article
PubMed Central
CAS
PubMed
Google Scholar
Schoorlemmer J, Jonk L, Sanbing S, van Puijenbroek A, Feijen A, Kruijer W: Regulation of Oct-4 gene expression during differentiation of EC cells. Mol Biol Rep. 1995, 21 (3): 129-140. 10.1007/BF00997235.
Article
CAS
PubMed
Google Scholar
Martín-Ibáñez R, Urbán N, Sergent-Tanguy S, Pineda JR, Garrido-Clua N, Alberch J, Canals JM: Interplay of leukemia inhibitory factor and retinoic acid on neural differentiation of mouse embryonic stem cells. J Neurosci Res. 2007, 85: 2686-2701. 10.1002/jnr.21228.
Article
PubMed
Google Scholar
Takahashi J, Palmer TD, Gage FH: Retinoic Acid and Neurotrophins Collaborate to Regulate Neurogenesis in Adult-Derived Neural Stem Cell Cultures. J Neurobiol. 1999, 38: 65-81. 10.1002/(SICI)1097-4695(199901)38:1<65::AID-NEU5>3.0.CO;2-Q.
Article
CAS
PubMed
Google Scholar
Chambon P: A decade of molecular biology of retinoic acid receptors. FASEB J. 1996, 10: 940-954.
CAS
PubMed
Google Scholar
Gottlieb DI, Huettner JE: An in vitro pathway from embryonic stem cells to neurons and glia. Cells Tissues Organs. 1999, 165: 165-172. 10.1159/000016696.
Article
CAS
PubMed
Google Scholar
Jonk LJ, Jonge ME de, Kruyt FA, Mummery CL, Saag PT, Kruijer van der W: Aggregation and cell cycle dependent retinoic acid receptor mRNA expression in P19 embryonal carcinoma cells. Mech Dev. 1992, 36: 165-172. 10.1016/0925-4773(92)90067-T.
Article
CAS
PubMed
Google Scholar
Yokota Y, Ohkubo H: 9-cis-Retinoic acid induces neuronal differentiation of retinoic acid-nonresponsive embryonal carcinoma cells. Exp Cell Res. 1996, 228: 1-7. 10.1006/excr.1996.0291.
Article
CAS
PubMed
Google Scholar
Cebrià F, Kobayashi C, Umesono Y, Nakazawa M, Mineta K, Ikeo K, Gojobori T, Itoh M, Taira M, Sánchez Alvarado A, Agata K: FGFR-related gene nou-darake restricts brain tissues to the head region of planarians. Nature. 2002, 419 (6907): 620-624. 10.1038/nature01042.
Article
PubMed
Google Scholar
Launay C, Fromentoux V, Shi DL, Boucaut JC: A truncated FGF receptor blocks neural induction by endogenous Xenopus inducers. Development. 1996, 122: 869-880.
CAS
PubMed
Google Scholar
Ma YG, Rosfjord E, Huebert C, Wilder P, Tiesman J, Kelly D, Rizzino A: Transcriptional regulation of the murine k-FGF gene in embryonic cell lines. Dev Biol. 1992, 154: 45-54. 10.1016/0012-1606(92)90046-J.
Article
CAS
PubMed
Google Scholar
Rathjen J, Lake JA, Bettess MD, Washington JM, Chapman G, Rathjen PD: Formation of a primitive ectoderm like cell population, EPL cells, from ESCs in response to biologically derived factors. J Cell Sci. 1999, 112: 601-612.
CAS
PubMed
Google Scholar
Kampmann E, Mey J: Retinoic acid enhances Erk phosphorylation in the chick retina. Neurosci Lett. 2007, 426 (1): 18-22. 10.1016/j.neulet.2007.07.039.
Article
CAS
PubMed
Google Scholar
Cañón E, Cosgaya JM, Scsucova S, Aranda A: Rapid effects of retinoic acid on CREB and ERK phosphorylation in neuronal cells. Mol Biol Cell. 2004, 15: 5583-5592. 10.1091/mbc.E04-05-0439.
Article
PubMed Central
PubMed
Google Scholar
Bost F, Caron L, Marchetti I, Dani C, Le Marchand-Brustel Y, Binétruy B: Retinoic acid activation of the ERK pathway is required for embryonic stem cell commitment into the adipocyte lineage. Biochem J. 2002, 361 (3): 621-627. 10.1042/0264-6021:3610621.
Article
PubMed Central
CAS
PubMed
Google Scholar
Li Z, Theus MH, Wei L: Role of ERK 1/2 signaling in neuronal differentiation of cultured embryonic stem cells. Develop Growth Differ. 2006, 48: 513-523. 10.1111/j.1440-169X.2006.00889.x.
Article
CAS
Google Scholar
Fuentealba LC, Eivers E, Ikeda A, Hurtado C, Kuroda H, Pera EM, De Robertis EM: Integrating patterning signals: Wnt/GSK3 regulates the duration of the BMP/Smad1 signal. Cell. 2007, 131 (5): 980-993. 10.1016/j.cell.2007.09.027.
Article
PubMed Central
CAS
PubMed
Google Scholar
Easwaran V, Pishvaian M, Salimuddin S, Byers S: Crossregulation of [beta]-catenin-LEF/TCF and retinoid signaling pathways. Curr Biol. 1999, 9: 1415-1418. 10.1016/S0960-9822(00)80088-3.
Article
CAS
PubMed
Google Scholar
Aubert J, Stavridis MP, Tweedie S, O'Reilly M, Vierlinger K, Li M, Ghazal P, Pratt T, Mason JO, Roy D, Smith A: Screening for mammalian neural genes via fluorescence-activated cell sorter purification of neural precursors from Sox1-gfp knock-in mice. Proc Natl Acad Sci USA. 2003, 100 (Suppl 1): 11836-11841. 10.1073/pnas.1734197100.
Article
PubMed Central
CAS
PubMed
Google Scholar