cAMP/PKA signaling balances respiratory activity with mitochondria dependent apoptosis via transcriptional regulation

Table 3 Selected genes uppregulated by elevated cAMP/TPK3 signalling

Function	Gene	Fold Change	Gene Function
DNA damage	HUG1	8.0	Responds to DNA damage or replication arrest, transcription is induced by DNA damage
	THI4	3.4	Thiazole synthase, required for thiamine biosynthesis and for mitochondrial genome stability
Nutrient sensing	HXT1	8.0	Glucose transporter, expressed in the presence of glucose, repressed when glucose is limited
	MIG2	5.0	Supressor of SUC2 expressed under high glucose levels
Mitochondrial Function	PUF3	2.4	OMM protein, linksArp2/3 complex with the mitochore promotes degradation of mRNAs for select nuclear-encoded mitochondrial proteins
	AAC3	3.4	IMM ADP/ATP translocator, exchanges cytosolic ADP for mitochondrially synthesized ATP; roles in maintenance of viability and in respiration

Genes involved in mitochondrial function, DNA damage response and nutrient sensing that were upregulated in Δpde2 cells but not in Δpde2 Δtpk3 when grown in the presence of exogenous cAMP. Gene lists were obtained as a ratio of statistically significant expression levels in Δpde2/Δpde2 Δtpk3 cells when grown in the presence of 4 mM cAMP.

ISSN: 2661-8850