Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S: The protein kinase complement of the human genome. Science. 2002, 298: 1912-1934. 10.1126/science.1075762.
Article
CAS
PubMed
Google Scholar
Bachmann M, Moroy T: The serine/threonine kinase Pim-1. Int J Biochem Cell Biol. 2005, 37: 726-730. 10.1016/j.biocel.2004.11.005.
Article
CAS
PubMed
Google Scholar
Selten G, Cuypers HT, Berns A: Proviral activation of the putative oncogene Pim-1 in MuLV induced T-cell lymphomas. Embo J. 1985, 4: 1793-1798.
PubMed Central
CAS
PubMed
Google Scholar
Selten G, Cuypers HT, Boelens W, Robanus-Maandag E, Verbeek J, Domen J, van Beveren C, Berns A: The primary structure of the putative oncogene pim-1 shows extensive homology with protein kinases. Cell. 1986, 46: 603-611. 10.1016/0092-8674(86)90886-X.
Article
CAS
PubMed
Google Scholar
van Lohuizen M, Verbeek S, Krimpenfort P, Domen J, Saris C, Radaszkiewicz T, Berns A: Predisposition to lymphomagenesis in pim-1 transgenic mice: cooperation with c-myc and N-myc in murine leukemia virus-induced tumors. Cell. 1989, 56: 673-682. 10.1016/0092-8674(89)90589-8.
Article
CAS
PubMed
Google Scholar
Breuer M, Wientjens E, Verbeek S, Slebos R, Berns A: Carcinogen-induced lymphomagenesis in pim-1 transgenic mice: dose dependence and involvement of myc and ras. Cancer Res. 1991, 51: 958-963.
CAS
PubMed
Google Scholar
Breuer ML, Cuypers HT, Berns A: Evidence for the involvement of pim-2, a new common proviral insertion site, in progression of lymphomas. Embo J. 1989, 8: 743-748.
PubMed Central
CAS
PubMed
Google Scholar
Allen JD, Verhoeven E, Domen J, van der Valk M, Berns A: Pim-2 transgene induces lymphoid tumors, exhibiting potent synergy with c-myc. Oncogene. 1997, 15: 1133-1141. 10.1038/sj.onc.1201288.
Article
CAS
PubMed
Google Scholar
Mochizuki T, Kitanaka C, Noguchi K, Sugiyama A, Kagaya S, Chi S, Asai A, Kuchino Y: Pim-1 kinase stimulates c-Myc-mediated death signaling upstream of caspase-3 (CPP32)-like protease activation. Oncogene. 1997, 15: 1471-1480. 10.1038/sj.onc.1201326.
Article
CAS
PubMed
Google Scholar
Shirogane T, Fukada T, Muller JM, Shima DT, Hibi M, Hirano T: Synergistic roles for Pim-1 and c-Myc in STAT3-mediated cell cycle progression and antiapoptosis. Immunity. 1999, 11: 709-719. 10.1016/S1074-7613(00)80145-4.
Article
CAS
PubMed
Google Scholar
Cuypers HT, Selten G, Berns A, Geurts van Kessel AH: Assignment of the human homologue of Pim-1, a mouse gene implicated in leukemogenesis, to the pter-q12 region of chromosome 6. Hum Genet. 1986, 72: 262-265. 10.1007/BF00291892.
Article
CAS
PubMed
Google Scholar
Amson R, Sigaux F, Przedborski S, Flandrin G, Givol D, Telerman A: The human protooncogene product p33pim is expressed during fetal hematopoiesis and in diverse leukemias. Proc Natl Acad Sci U S A. 1989, 86: 8857-8861.
Article
PubMed Central
CAS
PubMed
Google Scholar
Dhanasekaran SM, Barrette TR, Ghosh D, Shah R, Varambally S, Kurachi K, Pienta KJ, Rubin MA, Chinnaiyan AM: Delineation of prognostic biomarkers in prostate cancer. Nature. 2001, 412: 822-826. 10.1038/35090585.
Article
CAS
PubMed
Google Scholar
Deneen B, Welford SM, Ho T, Hernandez F, Kurland I, Denny CT: PIM3 proto-oncogene kinase is a common transcriptional target of divergent EWS/ETS oncoproteins. Mol Cell Biol. 2003, 23: 3897-3908. 10.1128/MCB.23.11.3897-3908.2003.
Article
PubMed Central
CAS
PubMed
Google Scholar
Fujii C, Nakamoto Y, Lu P, Tsuneyama K, Popivanova BK, Kaneko S, Mukaida N: Aberrant expression of serine/threonine kinase Pim-3 in hepatocellular carcinoma development and its role in the proliferation of human hepatoma cell lines. Int J Cancer. 2005, 114: 209-218. 10.1002/ijc.20719.
Article
CAS
PubMed
Google Scholar
Ionov Y, Le X, Tunquist BJ, Sweetenham J, Sachs T, Ryder J, Johnson T, Lilly MB, Kraft AS: Pim-1 protein kinase is nuclear in Burkitt's lymphoma: nuclear localization is necessary for its biologic effects. Anticancer Res. 2003, 23: 167-178.
CAS
PubMed
Google Scholar
Wang Z, Bhattacharya N, Mixter PF, Wei W, Sedivy J, Magnuson NS: Phosphorylation of the cell cycle inhibitor p21Cip1/WAF1 by Pim-1 kinase. Biochim Biophys Acta. 2002, 1593: 45-55. 10.1016/S0167-4889(02)00347-6.
Article
CAS
PubMed
Google Scholar
Mochizuki T, Kitanaka C, Noguchi K, Muramatsu T, Asai A, Kuchino Y: Physical and functional interactions between Pim-1 kinase and Cdc25A phosphatase. Implications for the Pim-1-mediated activation of the c-Myc signaling pathway. J Biol Chem. 1999, 274: 18659-18666. 10.1074/jbc.274.26.18659.
Article
CAS
PubMed
Google Scholar
Winn LM, Lei W, Ness SA: Pim-1 phosphorylates the DNA binding domain of c-Myb. Cell Cycle. 2003, 2: 258-262.
Article
CAS
PubMed
Google Scholar
Fox CJ, Hammerman PS, Cinalli RM, Master SR, Chodosh LA, Thompson CB: The serine/threonine kinase Pim-2 is a transcriptionally regulated apoptotic inhibitor. Genes Dev. 2003, 17: 1841-1854. 10.1101/gad.1105003.
Article
PubMed Central
CAS
PubMed
Google Scholar
Yan B, Zemskova M, Holder S, Chin V, Kraft A, Koskinen PJ, Lilly M: The PIM-2 kinase phosphorylates BAD on serine 112 and reverses BAD-induced cell death. J Biol Chem. 2003, 278: 45358-45367. 10.1074/jbc.M307933200.
Article
CAS
PubMed
Google Scholar
Aho TL, Sandholm J, Peltola KJ, Mankonen HP, Lilly M, Koskinen PJ: Pim-1 kinase promotes inactivation of the pro-apoptotic Bad protein by phosphorylating it on the Ser112 gatekeeper site. FEBS Lett. 2004, 571: 43-49. 10.1016/j.febslet.2004.06.050.
Article
CAS
PubMed
Google Scholar
Nosaka T, Kitamura T: Pim-1 expression is sufficient to induce cytokine independence in murine hematopoietic cells, but is dispensable for BCR-ABL-mediated transformation. Exp Hematol. 2002, 30: 697-702. 10.1016/S0301-472X(02)00808-1.
Article
CAS
PubMed
Google Scholar
Lilly M, Kraft A: Enforced expression of the Mr 33,000 Pim-1 kinase enhances factor-independent survival and inhibits apoptosis in murine myeloid cells. Cancer Res. 1997, 57: 5348-5355.
CAS
PubMed
Google Scholar
Puthalakath H, Strasser A: Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins. Cell Death Differ. 2002, 9: 505-512. 10.1038/sj.cdd.4400998.
Article
CAS
PubMed
Google Scholar
Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, Greenberg ME: Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell. 1997, 91: 231-241. 10.1016/S0092-8674(00)80405-5.
Article
CAS
PubMed
Google Scholar
Blume-Jensen P, Janknecht R, Hunter T: The kit receptor promotes cell survival via activation of PI 3-kinase and subsequent Akt-mediated phosphorylation of Bad on Ser136. Curr Biol. 1998, 8: 779-782. 10.1016/S0960-9822(98)70302-1.
Article
CAS
PubMed
Google Scholar
del Peso L, Gonzalez-Garcia M, Page C, Herrera R, Nunez G: Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. Science. 1997, 278: 687-689. 10.1126/science.278.5338.687.
Article
CAS
PubMed
Google Scholar
Hayakawa J, Ohmichi M, Kurachi H, Kanda Y, Hisamoto K, Nishio Y, Adachi K, Tasaka K, Kanzaki T, Murata Y: Inhibition of BAD phosphorylation either at serine 112 via extracellular signal-regulated protein kinase cascade or at serine 136 via Akt cascade sensitizes human ovarian cancer cells to cisplatin. Cancer Res. 2000, 60: 5988-5994.
CAS
PubMed
Google Scholar
Fang X, Yu S, Eder A, Mao M, Bast RCJ, Boyd D, Mills GB: Regulation of BAD phosphorylation at serine 112 by the Ras-mitogen-activated protein kinase pathway. Oncogene. 1999, 18: 6635-6640. 10.1038/sj.onc.1203076.
Article
CAS
PubMed
Google Scholar
Wolf D, Witte V, Laffert B, Blume K, Stromer E, Trapp S, d'Aloja P, Schurmann A, Baur AS: HIV-1 Nef associated PAK and PI3-kinases stimulate Akt-independent Bad-phosphorylation to induce anti-apoptotic signals. Nat Med. 2001, 7: 1217-1224. 10.1038/nm1101-1217.
Article
CAS
PubMed
Google Scholar
Harada H, Andersen JS, Mann M, Terada N, Korsmeyer SJ: p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD. Proc Natl Acad Sci U S A. 2001, 98: 9666-9670. 10.1073/pnas.171301998.
Article
PubMed Central
CAS
PubMed
Google Scholar
Lizcano JM, Morrice N, Cohen P: Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155. Biochem J. 2000, 349: 547-557. 10.1042/0264-6021:3490547.
Article
PubMed Central
CAS
PubMed
Google Scholar
Harada H, Becknell B, Wilm M, Mann M, Huang LJ, Taylor SS, Scott JD, Korsmeyer SJ: Phosphorylation and inactivation of BAD by mitochondria-anchored protein kinase A. Mol Cell. 1999, 3: 413-422. 10.1016/S1097-2765(00)80469-4.
Article
CAS
PubMed
Google Scholar
Virdee K, Parone PA, Tolkovsky AM: Phosphorylation of the pro-apoptotic protein BAD on serine 155, a novel site, contributes to cell survival. Curr Biol. 2000, 10: R883-10.1016/S0960-9822(00)00843-5.
Article
CAS
PubMed
Google Scholar
Dramsi S, Scheid MP, Maiti A, Hojabrpour P, Chen X, Schubert K, Goodlett DR, Aebersold R, Duronio V: Identification of a novel phosphorylation site, Ser-170, as a regulator of bad pro-apoptotic activity. J Biol Chem. 2002, 277: 6399-6405. 10.1074/jbc.M109990200.
Article
CAS
PubMed
Google Scholar
Konishi Y, Lehtinen M, Donovan N, Bonni A: Cdc2 phosphorylation of BAD links the cell cycle to the cell death machinery. Mol Cell. 2002, 9: 1005-1016. 10.1016/S1097-2765(02)00524-5.
Article
CAS
PubMed
Google Scholar
Masters SC, Yang H, Datta SR, Greenberg ME, Fu H: 14-3-3 inhibits Bad-induced cell death through interaction with serine-136. Mol Pharmacol. 2001, 60: 1325-1331.
CAS
PubMed
Google Scholar
Zha J, Harada H, Yang E, Jockel J, Korsmeyer SJ: Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L). Cell. 1996, 87: 619-628. 10.1016/S0092-8674(00)81382-3.
Article
CAS
PubMed
Google Scholar
Datta SR, Katsov A, Hu L, Petros A, Fesik SW, Yaffe MB, Greenberg ME: 14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation. Mol Cell. 2000, 6: 41-51. 10.1016/S1097-2765(00)00006-X.
Article
CAS
PubMed
Google Scholar
Tan Y, Demeter MR, Ruan H, Comb MJ: BAD Ser-155 phosphorylation regulates BAD/Bcl-XL interaction and cell survival. J Biol Chem. 2000, 275: 25865-25869. 10.1074/jbc.M004199200.
Article
CAS
PubMed
Google Scholar
Wang SW, Denny TA, Steinbrecher UP, Duronio V: Phosphorylation of Bad is not essential for PKB-mediated survival signaling in hemopoietic cells. Apoptosis. 2005, 10: 341-348. 10.1007/s10495-005-0808-4.
Article
CAS
PubMed
Google Scholar
Chiang CW, Kanies C, Kim KW, Fang WB, Parkhurst C, Xie M, Henry T, Yang E: Protein phosphatase 2A dephosphorylation of phosphoserine 112 plays the gatekeeper role for BAD-mediated apoptosis. Mol Cell Biol. 2003, 23: 6350-6362. 10.1128/MCB.23.18.6350-6362.2003.
Article
PubMed Central
CAS
PubMed
Google Scholar
Mikkers H, Nawijn M, Allen J, Brouwers C, Verhoeven E, Jonkers J, Berns A: Mice deficient for all PIM kinases display reduced body size and impaired responses to hematopoietic growth factors. Mol Cell Biol. 2004, 24: 6104-6115. 10.1128/MCB.24.13.6104-6115.2004.
Article
PubMed Central
CAS
PubMed
Google Scholar
Datta SR, Ranger AM, Lin MZ, Sturgill JF, Ma YC, Cowan CW, Dikkes P, Korsmeyer SJ, Greenberg ME: Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis. Dev Cell. 2002, 3: 631-643. 10.1016/S1534-5807(02)00326-X.
Article
CAS
PubMed
Google Scholar
Saris CJ, Domen J, Berns A: The pim-1 oncogene encodes two related protein-serine/threonine kinases by alternative initiation at AUG and CUG. Embo J. 1991, 10: 655-664.
PubMed Central
CAS
PubMed
Google Scholar
Andersson S, Davis DL, Dahlback H, Jornvall H, Russell DW: Cloning, structure, and expression of the mitochondrial cytochrome P-450 sterol 26-hydroxylase, a bile acid biosynthetic enzyme. J Biol Chem. 1989, 264: 8222-8229.
CAS
PubMed
Google Scholar
Sanchez I, Hughes RT, Mayer BJ, Yee K, Woodgett JR, Avruch J, Kyriakis JM, Zon LI: Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun. Nature. 1994, 372: 794-798.
Article
CAS
PubMed
Google Scholar
McCoy CE, Campbell DG, Deak M, Bloomberg GB, Arthur JS: MSK1 activity is controlled by multiple phosphorylation sites. Biochem J. 2005, 387: 507-517. 10.1042/BJ20041501.
Article
PubMed Central
CAS
PubMed
Google Scholar
Wiggin GR, Soloaga A, Foster JM, Murray-Tait V, Cohen P, Arthur JS: MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts. Mol Cell Biol. 2002, 22: 2871-2881. 10.1128/MCB.22.8.2871-2881.2002.
Article
PubMed Central
CAS
PubMed
Google Scholar
Campbell DG, Morrice N: Identification of protein phosphorylation sites by a combination of mass spectrometry and solid phase Edman sequencing. J Biom Tech. 2002, 13: 119-130.
Google Scholar
Moorhead G, MacKintosh C: Affinity methods for phosphorylation-dependent interactions. Methods Mol Biol. 2004, 261: 469-478.
CAS
PubMed
Google Scholar