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Table 1 A summary of the anti-angiogenic properties of cheiradone. IC50 values are The mean of three determinations.

From: Cheiradone: a vascular endothelial cell growth factor receptor antagonist

Experiment IC50 value ± SEM (μM)
  BAEC HDMEC
VEGF-R1 binding 2.9 ± 0.031  
VEGF-R2 binding 0.61 ± 0.14  
VEGF induced Proliferation 7.8 ± 1.2 7.4 ± 0.74
Effect on VEGF-induced wound healing 7.1 ± 0.77 6.50 ± .0.97
Effect on VEGF-induced migration 7.5 ± 0.92 5.20 ± 0.38
Effect on VEGF-induced tube formation 7.7 ± 1.5 6.0 ± 0.38
Effect on VEGF-induced invasion 6.3 ± 0.31 8.3 ± 1.0
Toxicity MTT NS NS
Toxicity Caspase-3 NS NS
  1. • NS = Overall inhibition is less than 50% and therefore IC50 values cannot be calculated.